Re: IGM, IGG, Immune system issues ?'s

[Guest guest]

Darla,

The other piece that I think they need to be looking at is if the " IG's " make a

good response to the prevnar or pneumovax, tetanus, (there's one more and I'm

blanking on it) vaccine. You can have a normal level of IgG's and yet they may

still not work well. Typically, this is tested by drawing antibody titers after

being vaccinated and then again in 6 months or so. Then they can tell if the

body makes enough antibodies and if it can sustain making those antibodies or if

the levels drop off after a few months or so. I have normal amounts of IgG

(altho a little low) but my IgG can't make or sustain a good response to the

pneumovax/prevnar. Now the implications of this is that many bacteria are made

like those targeted in that vaccine (they are considered the polysaccharide

coated bacteria)... so they know that I can't fight off those type of bacteria

very well and, thus, I used to (prior to gammaglobulin IVs) get many many

(almost continous) sinus infections.

The other piece is - I assume they tested for subclass IgG. In other words,

IgG1, IgG2, IgG3, and IgG4. You can have a low normal level of overall IgG, but

make little or none IgG2 (like my son Sam) and be much more vulnerable to

infections.

Okay... I don't know about the other questions b/c supposedly Sam and I are

non-mito.... my other son, Asher, is but at this point is not immune deficient.

Hope this helps

Anne R

[Guest guest]

Darla,

Looking at her numbers again - I'd really want to know what her subclass IgG's

are.... I hope they checked.

A good website can be found by typine in Primary Immune Deficiency.

HTH,

Anne R

[Guest guest]

Darla, Wyatt has low IgG and IgA. We don't know how long he has

been having immune problems. We stumbled across it by accident when

he had his feeding tube put in. I agree with Anne to have her IgG

subclasses tested along with her reaction to vaccinations. Wyatt's

numbers are not absent but low end normal or just a little bit below

normal. As soon as they realized he did not make antibodies to

vaccinations they suggested doing IVIG. However since he has been

fairly healthy we have decided to just do amoxicillian every day.

Anne is also write in telling you to check out the primary immune

deficiency website. It is a good one. Dawn also is a wealth of

info. She helped me out in the beginning.

Geri-Anne and Wyatt, Complex I

-- In Mito , " Darla Klein " <honeybear50317@m...> wrote:

> Zipporrah has been taking iron for the past 5-6 months (even

though Dr.

> Whiteman knows it can be a Mito toxin he recommended her taking it)

and her

> levels have some up very slowly to the low normal level. Her

hemoglobin is

> 12.3, iron 168, transferrin normal but don't have the number, and

the

> feritin is still only 12. Due to the fact that she constantly is

fighting

> viruses and isn't raising much quicker they ran some IGA, IGM, and

IGG

> levels. They said they are ok at present but in the low range so

we may

> need to run some immune system labs to see if she is dealing with

issues

> there. Her IGA is 38, her IGG is 488 (reference 400-1200), and her

IGM is

> 49 (reference 35-242). They said she definitely is on the lower

end and

> needs to be watched since she has been on iron so long with little

change.

> ??? To those who deal with these issues, what age did the

issues show

> for you and what were the levels your doctors began to worry and

treat with

> IVIG or other means? The doc did say the reference goes from

infants up to

> kids around 12 years of age so it is normal to be on the lower end,

but yet

> they said she is lower than they expected and desire her to be

since being

> on the iron supplement for so long. Any help here is appreciated.

Anything

> I should be looking for???

>

> See www.caringbridge.org/ia/mitomomof9 and

www.heartbeatsformito.org to see

> a photo look into what Mito looks like

> Darla: mommy to

> Asenath (4) Mito, CNS Vasculitis, strokes, migraines, seizures, G-

tube,

> hypotonicity, disautonomy, SID, global delays, asthma, cyclic

vomiting,

> bladder issues, wheelchair for distances, eye issues, autistic

behaviors,

> gastric emptying issues...

> Zipporrah (14 months) Mito, strokes, neuro-motor planning dys.,

SID, GERD,

> dysphasia, 100% G-tube fed, speech delays, extreme fatigue,

excessive

> phlegm, asthma, trach issues, aberrant subclavian artery,

disautonomy,

> hypertonicity, migraines, possible seizures, dumping syndrome, iron

> deficiency, ...

> Luke (16), Leah (14), Rachael (13), Isaac (10), Tirzah (8), Kezia

(4), &

> Marquis (3), Joey & (12 months) (some with Mito symptoms)