Re: Immunoglobulin level-- P.

[Guest guest]

Wow! That was great information and a lot of help. The IgM is the one

our GI doc is the most concerned about. She was the one to test the levels

on her rather than Dr. Whiteman. She informed Dr. Whiteman and they both

agree this is something we need to keep an eye on. I do not think the OD4,

CD8, or B-cells have been tested as the GI doc said we would probably pursue

more immune system type labs when we go to Mayo in February. To be honest,

I don't even know what those initials stand for. I am new to all of this

and haven't even had a chance to read up on it. Came to you experts first.

All I know is Zipporrah's iron level has been low for a while and so we

tried iron supplements and even though they have come up some, not nearly as

much as they should have according to the docs so the GI tested for these

issues and just gave me the results today.

See www.caringbridge.org/ia/mitomomof9 and www.heartbeatsformito.org to see

a photo look into what Mito looks like

Darla: mommy to

Asenath (4) Mito, CNS Vasculitis, strokes, migraines, seizures, G-tube,

hypotonicity, disautonomy, SID, global delays, asthma, cyclic vomiting,

bladder issues, wheelchair for distances, eye issues, autistic behaviors,

gastric emptying issues...

Zipporrah (14 months) Mito, strokes, neuro-motor planning dys., SID, GERD,

dysphasia, 100% G-tube fed, speech delays, extreme fatigue, excessive

phlegm, asthma, trach issues, aberrant subclavian artery, disautonomy,

hypertonicity, migraines, possible seizures, dumping syndrome, iron

deficiency, ...

Luke (16), Leah (14), Rachael (13), Isaac (10), Tirzah (8), Kezia (4), &

Marquis (3), Joey & (12 months) (some with Mito symptoms)

Immunoglobulin level-- for Darla

>

> It is important to watch immunoglobulin levels. Ironically, Evan was

> tested at 16 months for IgG, IgA, and IgM because he didn't seem to

> fight off infections well (no one suggested mito until 6 1/2 years

> later). The age adjusted ranges for 1 year olds are IgA (14.0-106.0),

> IgM (41 - 164), and IgG (345 - 1213). Porrah's IgM is her biggest

> concern. IgM are the " first responders " when there is a " new " exposure

> to a bug. Have you ever tested for CD4, CD8, or B-cells? Evan has low

> early B-cells which has contributed to his bouts with giardia. Here is

> some very basic info on Immunoglobin types--

>

> . Immunoglobulin types

> - IgA: Admiral; the navy, cruising mucosal (wet) surfaces as first line

> of defense. In tears, saliva, respiratory secretions, GI tract. \

> - Low IgA predisposes someone to autoimmune diseases and GI infections

> (rotavirus, giardia, etc.)

>

> Immunoglobulin – IgA

> - IgA deficiency: <10; low: 10-normal range

> - By age 5, about half of low values normalize in typical children.

>

> Immunoglobulin – IgM

> - IgM: Marines; small but rapidly deployed force who will hold things at

> bay until the main troops arrive.

>

> Immunoglobulin – IgG

> - IgG: General; the army – large force, takes longer to muster but once

> there, remains a long time to ensure control; if called for a second

> encounter with the same bug, much bigger response. Composed of 4

> subclasses. (IgG subclasses may be low if IgG is normal)

>

> Treatment: Low IgG

> - IVIG 400 mg/kg q 4 weeks as replacement dose.

>

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> Please contact mito-owner with any problems or questions.

>