RE: Cytochrome P450 function in mitochondrial disease?

[Guest guest]

I know nothing about teh cytochrome's or anything with the genetics, sorry. I did notice the issues with your liver. I'm not sure if this is the info you need or not.

My daughter's first clinical sign of mito was found in her liver. She did have alot of health issues, but all could have been passed off as something else. For her, the liver was on a very fast track to complete failure. Her enzymes were being checked every other day, only to find them doubling by the week. She had two needle biopsies, wich only showed alot of inflamation, but no reason. Finally she had a liver wedge (and muscle) biopsy wich confirmed her mito, and that she has periportal fibrosis due to all the inflamation.

Since the cocktail (Carnitor, inparticular), her liver is functioning completely normal. The fibrosis will never go away, but it should not be a problem as long as we are carefull with medications and she never gets a drinking habbit.

Best wishes

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