Re: Radioactivity Filter: Elaine, et al.

[Guest guest]

Hi Lil Deb,

I haven't heard of this, and I'm not sure how well a filter could remove all

the rays associated with I-131. It would be great if this were the case, but I

still don't think the thyroid gland should be destroyed when it's not even

causing the problems. Best, Elaine

[Guest guest]

Elaine,

I TOTALLY AGREE with you that the thyroid should NOT be destroyed when a

person has thyroid disease!

I was a little tired so I think I sounded like I was FOR destroying the

thyroid in that response I gave. I think this kind of filter would be overall

good for the thyroid scan and uptake, if a person chose to have one or was

unaware of the dangers of the radioactivity, or for any type of imaging that

requires a contrast medium that has radioactivity.

But even with this filter there still IS some radioactive particles as of

today, but not the same amount..apparently according to my surgeon very very

little and much safer than the regular and full strength radioactivity. WELL,

we

all know better, NO amount of radiation is safe! But if a person chose to

take these contrast mediums, it it better than full strength and the filter

would

be good in those situations.

lil deb

[Guest guest]

Shelly M.,

Here is a link to the mediboard with a link, when I found out about it:

http://www.mediboard.com/cgi-local/ubbcgi/ultimatebb.cgi?ubb=get_topic;f=1;t=0

03400

Here is the actual link, you have to register but it is free. From there you

can click on the doctors who worked on this study. Lanin was my surgeon.

When speaking with him...this study was an older one and this filter is in use

today for women with breast cancer..He said they, ( but I don't know who " they "

are) are working on it for other procedures for other diseases. I remember

seeing several studies on this paticular filter, but here is the one I found

quickly.

lil deb

http://research.bmn.com/medline/search/record?uid=MDLN.99153490 &

rendertype=full

Filtered versus unfiltered technetium sulfur colloid in lymphatic mapping: a

significant variable in a pig model.

<A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Tafra_L " >Tafra L</A>, <A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Chua_AN " >Chua AN</A>, <A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Ng_PC " >Ng PC</A>, <A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Aycock_D " >Aycock D</A>, <A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Swanson_M " >Swanson M</A>, <A

HREF= " http://research.bmn.com/medline/search/results?keyword_field=au & keywords= & \

#9; & 9;Lannin_D " >Lannin D</A>

Ann Surg Oncol 1999 Jan-Feb 6:83-7

BROWSE

:

<A

HREF= " http://research.bmn.com/medline/jbrowse?node=TOC@@MDLN@ann_surg_oncol " >Ann

Surg Oncol</A> • <A

HREF= " http://research.bmn.com/medline/jbrowse?node=TOC@@MDLN@ann_surg_oncol@6 " >V\

olume 6</A> • <A

HREF= " http://research.bmn.com/medline/jbrowse?node=TOC@@MDLN@ann_surg_oncol@6@1 " \

>Issue 1</A>

VIEW

:

<A

HREF= " http://research.bmn.com/medline/jbrowse/record?uid=MDLN.99153490 " >MEDLINE<\

/A>, full MEDLINE, <A

HREF= " http://research.bmn.com/medline/search/related?uid=MDLN.99153490 " >related

records</A>

Abstract

BACKGROUND: Lymphatic mapping with sentinel node biopsy is becoming a

standard diagnostic test for melanoma and is being extensively investigated for

use

with other soft tissue tumors. Both filtered and unfiltered technetium sulfur

colloid (Tc 99) have been used for preoperative lymphoscintigraphy, as well as

intraoperative lymphatic mapping, and it is not clear if one is preferable

over the other. The purpose of this study was to compare these two preparations

to determine whether the form of Tc 99 used affects the results of lymphatic

mapping. METHODS: Mock skin sites were placed on each extremity of 12 domestic

pigs totaling 48 skin sites. Twenty-four of the lesions were injected with

unfiltered Tc 99; the remaining 24 were injected with Tc 99 passed over a

0.2-microm filter. Both preparations of Tc 99 were mixed with 1 mL of isosulfan

blue

before injection. Sentinel node dissection was performed using a gamma probe,

with counts recorded over a 10-second period and timed to begin 5 minutes after

injection. RESULTS: Sentinel nodes were identified in all 48 lymph node

basins draining the mock sites and characterized as hot (10x background), blue,

or

both. Significantly more sentinel nodes were found in the filtered (105 total,

X = 4.4/basin), than in the unfiltered group (total 53, X = 2.2/basin, P <

..0001). The filtered group had both a higher number of nodes that were hot (35

vs. 6) and more nodes that were hot and blue (69 vs. 43). In addition, hot

secondary level lymph nodes (iliac and deep cervical) were found in 11 of 24 of

the

basins (46%) in the filtered group compared to 1 of 24 (4%) in the unfiltered

group (P <.003). There was no significant difference in injection site or

residual basin counts between the two groups, but in vivo counts over the

sentinel node sites were significantly lower in the unfiltered group (X =

2670+/-1829

vs. X = 6027+/-4333; P = .003). CONCLUSION: Use of filtered Tc 99 results in

more sentinel nodes (both hot/blue and hot non-blue) and a higher proportion

of secondary lymph nodes. These findings indicate that the Tc 99 preparation

used is a significant variable in the results of lymphatic mapping. It is

critical that future clinical studies document which preparation of Tc 99 was

used.

Only large clinical trials will be able to determine whether the additional

nodes found with filtered Tc 99 increase the sensitivity of the technique or

merely increase the number of nodes that must be removed unnecessarily.

MeSH

<A HREF= " http://research.bmn.com/medline/search/%3E " >Animal</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Biopsy</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Comparative Study</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Filtration</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Forelimb</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Hindlimb</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >

Injections, Intralymphatic</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Lymph Nodes</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Radiopharmaceuticals</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Skin</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Statistics,

Nonparametric</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Swine</A>; <A

HREF= " http://research.bmn.com/medline/search/%3E " >Technetium Tc 99m Sulfur

Colloid</A>

CAS Registry Number (Substance Name)

0 (Radiopharmaceuticals)

0 (Technetium Tc 99m Sulfur Colloid)

Comments

Ann Surg Oncol. 1999 Jan-Feb;6(1):12-410030408Ann Surg Oncol. 1999

Jul-Aug;6(5):514-610458695

Author Address

Department of Surgery, Leo Cancer Center, East Carolina University,

Greenville, North Carolina 27858, USA.

Abstracted by Journal Article Publication Type Journal Article

ISSN 1068-9265 Country UNITED STATES

Language eng Journal Code

Date of Entry 19990416 Entry Month 199904

Journal Subset IM Class Update Date 2001

Last Revision Date 20011126 Unique Identifier 99153490

[Guest guest]

Hi Deb,

Thanks for the link. I'll have to check this out.

Nah, I never thought you were promoting RAI but showing a way to reduce the

risk of diagnostic tests and cancer treatment. Studies show that the incidence

of developing other cancers is high after radiation therapy for cancer and

this would be a great way to reduce the risk. Enjoy the weekend, Elaine