Is serum Tg a good perdictor for relapse

October 23, 2003

Acta Endocrinol (Copenh). 1982 Mar;99(3):379-85. Related Articles,

Links

A prospective study of the differential changes in serum

thyroglobulin and its autoantibodies during propylthiouracil or

radioiodine therapy of patients with Graves' disease.

Feldt-Rasmussen U, Bech K, Date J, sen PH, Johansen K.

Measurement of serum thyroglobulin (Tg) and its autoantibody (TgAb)

by radioimmunological methods was performed in 48 patients with

Graves' disease during treatment with radioiodine (n = 16) or

propylthiouracil (PTU) (n = 32). Twenty-five of the 48 patients were

TgAb positive, their sera being inaccessible to measurement of serum

Tg. TgAb showed only minor changes during PTU treatment, whereas

TgAb fell rapidly after radioiodine, in 5 of 16 patients to

unmeasurable levels, followed by a secondary rise to 4.5 times pre-

treatment level after 20 weeks. Serum Tg showed a steady increase

during the first weeks after radioiodine treatment, but fell to

lower levels after one year. PTU caused only minor changes in the

serum Tg concentration. There was no shift in molecular sizes of

either Tg or TgAb during the course of the treatments. Five of 16

131I-treated patients developed myxoedema, 4 of whom were TgAb

positive. Another 3 patients had high increases in TgAb without

myxoedema. Six of 18 patients had relapse of thyrotoxicosis after

withdrawal of PTU-treatment. There was no significant difference in

serum concentrations of TgAb or Tg between those developing relapse

and those remaining in remission, and it is concluded that serum Tg

is a poor predictor of relapse in medically treated thyrotoxicosis.

October 23, 2003

These are the most outdated posts I've seen coming from this person.

It obviously is a person who is going to be right whether they are

wrong, or not. So, I've decided to start ignoring the posts.

I could have chosen RAI myself. I wasn't offered one thing by way of

ATD's until I told them I had no intentions of doing RAI, at anytime.

Guess that puts me in the class of people who get told this, then get

no other options explained. I however did NOT take the bait.

Sandy~Houston

On Thu, 23 Oct 2003 17:59:47 -0000

" leon_lz " wrote:

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