Guest guest Posted October 23, 2003 Report Share Posted October 23, 2003 Because ATD and RAI are around for many years, studies are done many years ago. Clin Endocrinol (Oxf). 1980 Nov;13(5):417-24. Related Articles, Links Influence of treatment with radioiodine and propylthiouracil on thyroid stimulating immunoglobulins in Graves' disease. Bech K, Nistrup Madsen S. Thyroid stimulating immunoglobulins (TSAb) were measured in fifty- four patients with Graves' disease before treatment with either radioiodine (seventeen patients) or propylthiouracil (PTU) (thirty- seven patients), and followed during treatment. After radioiodine TSAb increased to levels exceeding pretreatment values, and became detectable in three of six originally TSAb negative patients. In most patients TSAb decreased during treatment with PTU, and became undetectable after a mean of 12 months in patients above 40 years, and after a mean of 6 months in patients below 40 years. In order to eliminate the presumed causative agent in Graves' disease, antithyroid treatment should be at least 18 months in patients above 40 years, and at least 12 months in patients below 40 years of age. In twenty-nine patients TSAb were measured at cessation of 2 years antithyroid drug therapy. Ten patients were TSAb positive and all except one relapsed. Five of nineteen TSAb negative patients relapsed. Although TSAb positivity predict relapse, it is not an ideal index of prognosis after antithyroid therapy. Quote Link to comment Share on other sites More sharing options...
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