Guest guest Posted October 22, 2003 Report Share Posted October 22, 2003 From what I am reading here, I believe this study is not a long-term follow-up. That is, they use steroids to reduce the risk of eye involvement, and it was probably helpful in the short run, but what happens after they discontinue the steroid? This question remains unanswered. At 04:23 PM 10/22/2003, you wrote: >Thyroid. 1992 Summer;2(2):171-8. Related Articles, Links > > >Relationship between Graves' ophthalmopathy and type of treatment of >Graves' hyperthyroidism. > >Marcocci C, Bartalena L, Bogazzi F, Bruno-Bossio G, Pinchera A. > >Istituto di Endocrinologia, Universita di Pisa, Italy. > >The relationship between the treatment of Graves' hyperthyroidism >and the course of ophthalmopathy is rather unclear. Antithyroid >drugs may improve eye manifestations, possibly by restoring normal >thyroid function and reducing orbit-directed autoimmune reactions, >whereas ophthalmopathy may worsen after radioiodine administration >or thyroidectomy. This might occur because of a treatment-related >release of thyroid antigens and activation of the autoimmune >response that might involve the orbit. On the other hand, some >authors suggest that complete thyroid ablation, either by >radioiodine or surgery, might be beneficial for ophthalmopathy. >However, reported effects of radioiodine and thyroidectomy on >Graves' ophthalmopathy are conflicting. This may be due, at least in >part, to the retrospective feature of most studies and the lack of >precise evaluation of ocular involvement. Two prospective studies >were performed in which patients with Graves' disease with mild or >no ophthalmopathy were randomly assigned to treatment by radioiodine >or subtotal thyroidectomy alone or in association with systemic >glucocorticoids. Both treatments were followed by a progression of >pre-existing mild ophthalmopathy in a substantial proportion of >cases: glucocorticoids prevented such an exacerbation. >Ophthalmopathy did not develop in patients without clinical evidence >of eye disease prior to therapy. Therefore, it is recommended that a >course of glucocorticoids be instituted concomitantly with >radioiodine therapy or thyroidectomy in Graves' patients with some >degree of ocular involvement. > >Publication Types: >Clinical Trial >Randomized Controlled Trial >Review >Review, Tutorial Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2003 Report Share Posted October 23, 2003 In a message dated 10/22/2003 4:48:19 PM Eastern Daylight Time, aconner@... writes: > That is, they use steroids to reduce the risk of eye > involvement, and it was probably helpful in the short run, but what happens > after they discontinue the steroid? Exactly, .... I had RAI 2 years ago and my TSI antibodies are still at 240%. (Limits<130%) Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.