Stanhope's answer re kidney/urinary problems

[Guest guest]

Hello again,

Jen Salem here. The other questions you all raised was about the

WebMD Health website and Medline Plus Encyclopedia saying that RSS

children are at risk for " abnormalities of the kidney and urinary

tract, and at an increased risk for liver tumors. "

Stanhope replied with the following:

" You [me/Jen]are quite right that there are abnormalities of the

urinary tract associated with RSS. This usually includes

hypospadius, undescended testes, as well as inguingal herniae.

These are just more common than in normal boys. Because there is an

increased incidence of hypospadius, there must be an increased

incidence of other abnormalities of the urinary tract, although I do

not now the evidence for this. The two features of upper and lower

urinary congenital tract abnormalities usually go together.

And you are correct in the belief that it is important to

distinguish between hypoplasia of one limb, or hyperplasia of the

contralateral limb. In cases of the latter, this is associated with

Wilm's tumors, but not the former. There are many conditions

associated with limb asymmetry and RSS is just one of them. "

SO, if you do not understand any of that .... I emailed him back to

clarify. And essentially it is this:

Those websites above still have some incorrect info!!!

RSS kids definitely have an increased incidence of urinary tract

abnormalities, and as Dr. Stanhope wrote, because the upper and

lower are connected, it is appropriate to monitor the upper as well,

which means the kidneys. So not that RSS kids necessarily have been

found to have kidney problems more often, but that because of the

lower urinary tract problems, the kidney should be monitored as well.

HOWEVER, RSS children are not at risk for liver tumors, or Wilm's

tumors. This is because these tumors are correlated with asymmetry

when the smaller side is actually the NORMAL side. In cases of RSS,

the smaller side is the ABNORMAL side, known as hypoplasia of one

limb.

Hope this helps!!! Salem

[Guest guest]

Hi Jen

Any chance you could send me the replys from Dr Stanhope!

We have just had blood tests back on Liam showing slightly increased

urea, creatinine, cholesterol, and calciferol. Id like to take Dr

Stanhopes reply about the kidneys to our paed when we go. Also Liams

IGH-1 is high, it was last time checked to, intrested to hear more

about that.

I cant believe you posted all this, right when I need some answers.

Have to go

Thanks

Jody(mum to Liam and Cameron)

>

> Hello again,

>

> Jen Salem here. The other questions you all raised was about the

> WebMD Health website and Medline Plus Encyclopedia saying that RSS

> children are at risk for " abnormalities of the kidney and urinary

> tract, and at an increased risk for liver tumors. "

>

> Stanhope replied with the following:

>

> " You [me/Jen]are quite right that there are abnormalities of the

> urinary tract associated with RSS. This usually includes

> hypospadius, undescended testes, as well as inguingal herniae.

> These are just more common than in normal boys. Because there is

an

> increased incidence of hypospadius, there must be an increased

> incidence of other abnormalities of the urinary tract, although I

do

> not now the evidence for this. The two features of upper and

lower

> urinary congenital tract abnormalities usually go together.

>

> And you are correct in the belief that it is important to

> distinguish between hypoplasia of one limb, or hyperplasia of the

> contralateral limb. In cases of the latter, this is associated

with

> Wilm's tumors, but not the former. There are many conditions

> associated with limb asymmetry and RSS is just one of them. "

>

> SO, if you do not understand any of that .... I emailed him back

to

> clarify. And essentially it is this:

>

> Those websites above still have some incorrect info!!!

>

> RSS kids definitely have an increased incidence of urinary tract

> abnormalities, and as Dr. Stanhope wrote, because the upper and

> lower are connected, it is appropriate to monitor the upper as

well,

> which means the kidneys. So not that RSS kids necessarily have

been

> found to have kidney problems more often, but that because of the

> lower urinary tract problems, the kidney should be monitored as

well.

>

> HOWEVER, RSS children are not at risk for liver tumors, or Wilm's

> tumors. This is because these tumors are correlated with

asymmetry

> when the smaller side is actually the NORMAL side. In cases of

RSS,

> the smaller side is the ABNORMAL side, known as hypoplasia of one

> limb.

>

> Hope this helps!!! Salem