Guest guest Posted July 2, 2003 Report Share Posted July 2, 2003 Can anyone tell me what the TSI and TBI test results mean? I have the results but I'm not sure what it means. TSI 9.1 Range 70-150 TBI 11.1 Range *less than 5 I am post RAI about 19 months and still not been able to get my levels to level out. Thanks in advance for your help! Debbie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2003 Report Share Posted July 2, 2003 Hi Debbie, TSI are thyroid stimulating immunoglobulins (also known as stimulating TSH receptor antibodies), the ones that cause hyperthyroidism in GD. After RAI the immune system is stimulated to produce more TSH receptor antibodies. Some people produce more stimulating antibodies and some produce more blocking antibodies. The test for TBII measures both stimulating and blocking TSH receptor antibodies. When both stimulating and blocking antibodies are present, the risk of Graves' ophthalmopathy is high. When any TSH receptor antibodies are present, it's hard to regulate thyroid hormone levels; the blocking antibodies generally contribute to a worsening of hypothyroidism. Hope this helps, Elaine Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 8, 2003 Report Share Posted July 8, 2003 So in your opion what do the levels I posted mean to you? I'm still a little confused TSI 91 Range 70-150 TBI 11.1 Range *less than 5 thanks for your help! Debbie > Hi Debbie, > TSI are thyroid stimulating immunoglobulins (also known as stimulating TSH > receptor antibodies), the ones that cause hyperthyroidism in GD. After RAI the > immune system is stimulated to produce more TSH receptor antibodies. Some > people produce more stimulating antibodies and some produce more blocking > antibodies. > > The test for TBII measures both stimulating and blocking TSH receptor > antibodies. When both stimulating and blocking antibodies are present, the risk of > Graves' ophthalmopathy is high. When any TSH receptor antibodies are present, > it's hard to regulate thyroid hormone levels; the blocking antibodies generally > contribute to a worsening of hypothyroidism. Hope this helps, Elaine > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 8, 2003 Report Share Posted July 8, 2003 Hi TSI (stimulating TSH receptor antibodies) and also blocking TSH receptor antibodies both contribute to GO. Blocking antibodies prevent TSH and TSI from reacting with the cell receptor so they can make hyper symptoms not as severe or levels as high even with high TSI levels. and people with equal amounts of both antibodies can have normal thyroid function.these people usually develop GO and are said to have euthyroid Graves' disease since thyroid function is ok. When blocking antibodies predominate people move into hypoT. TSI is important for hyperthyroidism because it's what directly cause GD and ideally you want your immune system to stop producing it. People with high concentrations of both stimulating and blocking TSH receptor antibodies are at most risk for GO. These are both measured together by doing a TBII test. In GO, your goal is to have the immune system produce no TSH receptor antibodies because GO can persist if you stop producing TSI and still produce blocking antibodies and move into hypoT. Hope this helps, elaine Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 8, 2003 Report Share Posted July 8, 2003 This suggests that you have both blocking and stimulating TSH receptor antibodies. If you're on ATDs you're probably not producing sufficient TSI to cause hyperT but you would if you were off meds. Quote Link to comment Share on other sites More sharing options...
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