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Re: Re CREON

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You need a prescription for this, then any pharmacy can get it for

you. It's a digestive enzyme that mostly works on fats (lipase).

Terri

At 02:33 PM 6/22/01 -0400, you wrote:

>Hi: has anyone heard of Creon? Dr. Kartzinel wants Evan to begin, this, but

>I do not know where to get it. Vendor or phone number would be great.

>Thanks, Z.

>

>

>

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Hi: has anyone heard of Creon? Dr. Kartzinel wants Evan to begin, this, but

I do not know where to get it. Vendor or phone number would be great.

Thanks, Z.

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This is some information on Creon from past posts from Devin Houston.

It sounds like you need a prescription:

Creon, or Kreon, is an enteric-coated prescription formula of

pancreatic enzymes. It is primarily used for those with cystic

fibrosis to help with the steatorrhea (fat in stools). It is enteric-

coated because pancreatic enzymes can't withstand the acid

environment of the stomach. The problem with enteric-coating is it

adds expense to a product, and release of the active drug can be

variable and inconsistent.

---------------------

Creon (Kreon) vs plant enzymes: Creon is a preparation of pancreatic

enzymes derived from pig or cow pancreas. Products such as Peptizyde

are derived from papaya, pineapple or cultivated Aspergillus

niger/oryzae organisms. Creon is treated with something like methyl

acrylate to provide protection from stomach acid, as pancreatic

enzymes only work in the pH range of 6.5 to 8.5. Plant enzymes are

naturally stable to acid, with a working pH range of 2.5 to 9,

depending on the particular enzyme.

Creon is predominantly lipase, with protease and amylase activities.

Plant enzymes are more separated in their activities, so one can

customize the particular enzyme combination to affect proteins,

complex carbs, or triglycerides. Creon usually requires a

prescription, plant enzymes are sold as dietary supplements and do

not require a doctor's script. Creon has been shown to help some

autists, thus indicating that any enzyme product may be helpful to a

subset of individuals.

----------------------

Creon is not new, it has been used for decades mostly for cystic

fibrosis patients and those with pancreatic insufficiency. Creon is

merely a pharmaceutical-grade extract of pig or cow pancreas (the

slaughterhouses have to do something with all those pancreases

(pancrei?)). The activity of Creon is primarily lipase (breaks down

triglycerides) with protease and amylase also present. It is used to

treat steatorrhea (fat in poop), breaking down fats so they are

absorbed rather than excreted.

Pancreatic enzymes are pH-sensitive, meaning that they are rapidly

inactivated by stomach acid. To overcome this, they are coated such

that the enzymes are not released until well into the small

intestine. Methyl acrylate is used in the coating process, I don't

particularly care for that chemical in my system, thank you.

The problem with the enzymes not being released until in the

intestine defeats the purpose of taking enzymes for peptide

elimination. Once the casein and gluten are in the gut, any peptides

produced will be absorbed quickly. Plant enzymes work in the stomach,

so the protein breakdown process starts sooner (peptides aren't

absorbed in the stomach) so less chance of peptides escaping.

> Hi: has anyone heard of Creon? Dr. Kartzinel wants Evan to begin,

this, but

> I do not know where to get it. Vendor or phone number would be

great.

> Thanks, Z.

>

>

>

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