they really did detailed study in spain

[Guest guest]

here is another paper from Spain, they looked back for the patients

they treated. The previous paper was about the patients they

enrolled in a study. one called retrospective and the other called

propective.

[Recurrence and prognostic factors after treatment with antithyroid

agents in Graves-Basedow disease. Multicenter study in Northern

Spain]

[Article in Spanish]

Menendez Torre E, Anda Apinaniz E, Barberia Layana JJ, Valdes

Gallego N, Rabal Artal A, -Cadorniga F, Santamaria Sandi J,

Vazquez JA.

Servicio de Endocrinologia, Hospital de Navarra, Pamplona.

Therapy with anti-thyroid drugs is the initial option mostly used in

our country for the treatment of hyperthyroidism due to Graves-

Basedow disease. To evaluate the long term results of this kind of

therapy, a total of 773 patients were studied who were diagnosed

from 1975 to 1994 in three hospitals in Northern Spain (Hospital

Central de Asturias, Hospital de Cruces and Hospital de Navarra)

after a mean follow-up time after anti-thyroid drug withdrawal of 46

+/- 33.1 months. The results showed a likelihood of hyperthyroidism

relapse of 42.9%, 59.8%, 67.9% and 78.9% at one, three, five and ten

years, respectively. Goitre size was correlated very significantly

with the likelihood of relapse (p < 0.0001). In contrast, only TBII

positivity at the end of therapy among the remaining parameters

(age, sex, goitre size, length of therapy, positivity of anti-

thyroid antibodies and TBII) influenced significantly on the relapse

likelihood (p < 0.05). In conclusion, after a long term follow-up

after anti-thyroid therapy, a high relapse rate of hyperthyroidism

in Graves-Basedow disease, which amounts up to 79% at ten years, was

observed. Goitre size was the main predictive factor for this

relapse.

Publication Types:

Multicenter Study