Article on Miotochondrial disease OT

[Guest guest]

Evidence of Mitochondrial Dysfunction in Autism and Implications for Treatment

Authors: A. Rossignol MD FAAFP and, J. Bradstreet MD FAAFP,

International Child Development Resource Center, 3800 W. Eau Gallie Blvd.,

Suite 105, Melbourne, FL 32934

Evidence of Mitochondrial Dysfunction in Autism and Implications for Treatment

was recently accepted to the American Journal of Biochemistry and Biotechnology

Abstract

Classical mitochondrial diseases occur in a subset of autistic individuals and

are usually caused by genetic anomalies or mitochondrial respiratory pathway

abnormalities. However, in many autistic individuals, there is evidence of

mitochondrial dysfunction (MtD) without the classical features associated with

mitochondrial disease. In comparison to mitochondrial disease, MtD occurs more

commonly in autism, is not as severe in symptomatology, and is not associated

with any discernable mitochondrial abnormality upon muscle biopsy. It is,

however, associated with laboratory evidence of lowered mitochondrial

functioning. MtD is likely precipitated by environmental toxins, and could

contribute to a number of diagnostic symptoms and comorbidities observed in

autism including: cognitive impairment, language deficits, abnormal energy

metabolism, chronic gastrointestinal problems, abnormalities in fatty acid

oxidation, and increased oxidative stress. MtD and oxidative stress may also

explain the high male to female ratio found in autism due to the fact that males

have an increased vulnerability to these dysfunctions. Although biomarkers for

mitochondrial deficiency have been identified, it appears that MtD is

significantly under-recognized in autism, and therefore, potentially beneficial

therapies are widely under-prescribed. These treatments include nutritional

supplementation to increase glutathione levels and decrease oxidative stress, as

well as hyperbaric oxygen therapy. The underlying pathophysiology and core

autistic symptoms of affected individuals would be expected to improve when

treatment for MtD is implemented.

Sent to you by Antoinette

If this could be you or your child go to www.umdf.org<http://www.umdf.org/>

[Guest guest]

Thank you so much for posting this!!! This fits my

little son to a " T " . I've just been stressing about

this, and your post could not have come at a more

perfect time!

Best regards,

Rhona

--- Bunce wrote:

>

> Evidence of Mitochondrial Dysfunction in Autism and

> Implications for Treatment

> Authors: A. Rossignol MD FAAFP and, J.

> Bradstreet MD FAAFP,

> International Child Development Resource Center,

> 3800 W. Eau Gallie Blvd.,

> Suite 105, Melbourne, FL 32934

>

> Evidence of Mitochondrial Dysfunction in Autism and

> Implications for Treatment was recently accepted to

> the American Journal of Biochemistry and

> Biotechnology

>

> Abstract

> Classical mitochondrial diseases occur in a subset

> of autistic individuals and are usually caused by

> genetic anomalies or mitochondrial respiratory

> pathway abnormalities. However, in many autistic

> individuals, there is evidence of mitochondrial

> dysfunction (MtD) without the classical features

> associated with mitochondrial disease. In comparison

> to mitochondrial disease, MtD occurs more commonly

> in autism, is not as severe in symptomatology, and

> is not associated with any discernable mitochondrial

> abnormality upon muscle biopsy. It is, however,

> associated with laboratory evidence of lowered

> mitochondrial functioning. MtD is likely

> precipitated by environmental toxins, and could

> contribute to a number of diagnostic symptoms and

> comorbidities observed in autism including:

> cognitive impairment, language deficits, abnormal

> energy metabolism, chronic gastrointestinal

> problems, abnormalities in fatty acid oxidation, and

> increased oxidative stress. MtD and oxidative stress

> may also explain the high male to female ratio found

> in autism due to the fact that males have an

> increased vulnerability to these dysfunctions.

> Although biomarkers for mitochondrial deficiency

> have been identified, it appears that MtD is

> significantly under-recognized in autism, and

> therefore, potentially beneficial therapies are

> widely under-prescribed. These treatments include

> nutritional supplementation to increase glutathione

> levels and decrease oxidative stress, as well as

> hyperbaric oxygen therapy. The underlying

> pathophysiology and core autistic symptoms of

> affected individuals would be expected to improve

> when treatment for MtD is implemented.

>

> Sent to you by Antoinette

>

> If this could be you or your child go to

> www.umdf.org<http://www.umdf.org/>

>

> [Non-text portions of this message have been

> removed]

>

>

________________________________________________________________________________\

____

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[Guest guest]

Hi Antoinette and List Members,

I find this article to be very fascinating. It is saying that there are two

types of

mitochondrial diseases:

classical mitochondrial diseases and MtD.According to the article that

Antoinette just posted::

" In comparison to mitochondrial disease, MtD occurs more commonly in autism, is

not as severe in symptomatology, and is not associated with any discernable

mitochondrial abnormality upon muscle biopsy. It is, however, associated with

laboratory evidence of lowered mitochondrial functioning. MtD is likely

precipitated by environmental toxins, and could contribute to a number of

diagnostic symptoms and comorbidities observed in autism including: cognitive

impairment, language deficits, abnormal energy metabolism, chronic

gastrointestinal problems, abnormalities in fatty acid oxidation, and increased

oxidative stress. "

What could the environmental trigger be? I agree that toxins might be the

culprit because toxins impair the digestive system and thus increase the amount

of bacterial toxins. Research on Medline indicates that bacterial toxins might

be responsible for every symptom of MtD. LPS is a bacterial toxin that is very

commonly found in autistic children and other people with carbohydrate

malabsorption. Research articles show a link between LPS and most symptoms of

ASD including those of MtD.

To learn about LPS

http://microbialinfluence.com/ASD.html

http://microbialinfluence.com/SCD.html

To read the link between LPS and the symptoms of MtD:

fatty acid oxidation

http://microbialinfluence.com/fattyacid.html

oxidative stress

http://microbialinfluence.com/oxidative.html

cognitive impairment and language deficits,

http://microbialinfluence.com/Brain.html

abnormal energy metabolism

http://microbialinfluence.com/energy.html

It is very important to do SCD if your child has symptoms that are caused by

LPS.

Antoinette's children seem to have classical mitochondrialI disease rather tha

MtD. I do not know enough about Antoinette's family's medical situation to give

any type of recommendation. Please understand that I am only discussing MtD and

not classical mitochondrial diseases. Classical mitochondrial disease might

need special medical attention.

Mimi

>MtD is likely precipitated by

> environmental toxins, and could contribute to a number of diagnostic

> symptoms and comorbidities observed in autism including: cognitive

> impairment, language deficits, abnormal energy metabolism, chronic

> gastrointestinal problems, abnormalities in fatty acid oxidation, and

> increased oxidative stress.

[Guest guest]

--- Hi Mimi,

thanks for the recent link to articles for Jazzies G.I. I am also

finding these articles about LPS extremely interesting. Would it be

o.k. to post the link to a bio-med discussion group, who I think

would find this very useful. Thanks again.

Glynis mam to Jasmine 7 yrs

Diagnosed with Kabuki Syndrome

NG tube fed

In pecanbread , " pecan post " wrote:

>

> Hi Antoinette and List Members,

>

> I find this article to be very fascinating. It is saying that there

are two types of

> mitochondrial diseases:

> classical mitochondrial diseases and MtD.According to the article

that Antoinette just posted::

> " In comparison to mitochondrial disease, MtD occurs more commonly

in autism, is not as severe in symptomatology, and is not associated

with any discernable mitochondrial abnormality upon muscle biopsy. It

is, however, associated with laboratory evidence of lowered

mitochondrial functioning. MtD is likely precipitated by

environmental toxins, and could contribute to a number of diagnostic

symptoms and comorbidities observed in autism including: cognitive

impairment, language deficits, abnormal energy metabolism, chronic

gastrointestinal problems, abnormalities in fatty acid oxidation, and

increased oxidative stress. "

>

> What could the environmental trigger be? I agree that toxins might

be the culprit because toxins impair the digestive system and thus

increase the amount of bacterial toxins. Research on Medline

indicates that bacterial toxins might be responsible for every

symptom of MtD. LPS is a bacterial toxin that is very commonly found

in autistic children and other people with carbohydrate

malabsorption. Research articles show a link between LPS and most

symptoms of ASD including those of MtD.

>

> To learn about LPS

> http://microbialinfluence.com/ASD.html

> http://microbialinfluence.com/SCD.html

> To read the link between LPS and the symptoms of MtD:

> fatty acid oxidation

> http://microbialinfluence.com/fattyacid.html

> oxidative stress

> http://microbialinfluence.com/oxidative.html

> cognitive impairment and language deficits,

> http://microbialinfluence.com/Brain.html

> abnormal energy metabolism

> http://microbialinfluence.com/energy.html

>

> It is very important to do SCD if your child has symptoms that are

caused by LPS.

>

> Antoinette's children seem to have classical mitochondrialI disease

rather tha MtD. I do not know enough about Antoinette's family's

medical situation to give any type of recommendation. Please

understand that I am only discussing MtD and not classical

mitochondrial diseases. Classical mitochondrial disease might need

special medical attention.

>

> Mimi

> >MtD is likely precipitated by

> > environmental toxins, and could contribute to a number of

diagnostic

> > symptoms and comorbidities observed in autism including: cognitive

> > impairment, language deficits, abnormal energy metabolism, chronic

> > gastrointestinal problems, abnormalities in fatty acid oxidation,

and

> > increased oxidative stress.

>

[Guest guest]

Glynis,

Thank you for your offer to share the new website.

Everyone has the right to post the link to a bio-med discussion group.

I would love to read the feedback from other groups so I would

appreciate the name of the group (in private email) but I am not

requiring it.

Mimi

> --- Hi Mimi,

>

> thanks for the recent link to articles for Jazzies G.I. I am also

> finding these articles about LPS extremely interesting. Would it be

> o.k. to post the link to a bio-med discussion group, who I think

> would find this very useful. Thanks again.

>

> Glynis mam to Jasmine 7 yrs

> Diagnosed with Kabuki Syndrome

> NG tube fed

>

> In pecanbread , " pecan post " wrote:

> >

> > Hi Antoinette and List Members,

> >

> > I find this article to be very fascinating. It is saying that there

> are two types of

> > mitochondrial diseases:

> > classical mitochondrial diseases and MtD.According to the article

> that Antoinette just posted::

> > " In comparison to mitochondrial disease, MtD occurs more commonly

> in autism, is not as severe in symptomatology, and is not associated

> with any discernable mitochondrial abnormality upon muscle biopsy. It

> is, however, associated with laboratory evidence of lowered

> mitochondrial functioning. MtD is likely precipitated by

> environmental toxins, and could contribute to a number of diagnostic

> symptoms and comorbidities observed in autism including: cognitive

> impairment, language deficits, abnormal energy metabolism, chronic

> gastrointestinal problems, abnormalities in fatty acid oxidation, and

> increased oxidative stress. "

> >

> > What could the environmental trigger be? I agree that toxins might

> be the culprit because toxins impair the digestive system and thus

> increase the amount of bacterial toxins. Research on Medline

> indicates that bacterial toxins might be responsible for every

> symptom of MtD. LPS is a bacterial toxin that is very commonly found

> in autistic children and other people with carbohydrate

> malabsorption. Research articles show a link between LPS and most

> symptoms of ASD including those of MtD.

> >

> > To learn about LPS

> > http://microbialinfluence.com/ASD.html

> > http://microbialinfluence.com/SCD.html

> > To read the link between LPS and the symptoms of MtD:

> > fatty acid oxidation

> > http://microbialinfluence.com/fattyacid.html

> > oxidative stress

> > http://microbialinfluence.com/oxidative.html

> > cognitive impairment and language deficits,

> > http://microbialinfluence.com/Brain.html

> > abnormal energy metabolism

> > http://microbialinfluence.com/energy.html

> >

> > It is very important to do SCD if your child has symptoms that are

> caused by LPS.

> >

> > Antoinette's children seem to have classical mitochondrialI disease

> rather tha MtD. I do not know enough about Antoinette's family's

> medical situation to give any type of recommendation. Please

> understand that I am only discussing MtD and not classical

> mitochondrial diseases. Classical mitochondrial disease might need

> special medical attention.

> >

> > Mimi

> > >MtD is likely precipitated by

> > > environmental toxins, and could contribute to a number of

> diagnostic

> > > symptoms and comorbidities observed in autism including: cognitive

> > > impairment, language deficits, abnormal energy metabolism, chronic

> > > gastrointestinal problems, abnormalities in fatty acid oxidation,

> and

> > > increased oxidative stress.

> >

>

>

>

[Guest guest]

Dear Rhonda,

If this fits your son to a T, please go to www.umdf.org<http://www.umdf.org/>

and find out what to do next. Your journey is not going to be an easy one. I

will be there to support you off serve if you need it.

I sent this to Pecan bread, because the AUTISM SOCIETY of America is realizing

that MANY PDD/NOS and " High functioning " forms of " atypical " autism are

mitochondrial disease (MtD) in origin. Plan FACT...We ARE BEING MISSED by

ignorant doctors who do not know. This can be very " mild " to " fetal " ....the

mild cases....are the worse to detect. Blood work is not always indicative of

having it either. BEWARE of this. The specialist know it...but your doctors

might not.

The thing is, VERY few doctors realize what this is about...and you will have to

go to mitochondria specialist either in Atlanta Georgia or Cleveland Ohio.. THE

BEST in the COUNTRY. United WAY should be able to help you with the cost of the

trip! Well worth it to get answers now. Children with diagnosis...will be

first in line for new therapies (like stem cell etc...) that might be able to

" cure " this when they find a cure. It is worth it to have your confirmed

diagnosis! MILLIONS of dollars are being spent to find a cure for MtD. You

never know when it will happen.

Antoinette

" The important thing is never to stop questioning. "

-Albert Einstein