Anyone with access to Medline?

[Guest guest]

Well, fellow travelers, this particular review seems to bode a lot

for members of this group. If anyone here has access to MedLine,

could you please get the whole article and send it to me and also to

Mark so that we can add it to the 5Top5 site to share? Here's all

that I have with the MedLine Reference Number as well:

Pathogenesis of chronic pancreatitis: an evidence-based review of

past theories and recent developments.

s T, Conwell DL, Zuccaro G.

The Pancreas Clinic, Section of Endoscopy and Pancreaticobiliary

Disease, Department of Gastroenterology and Hepatology, Cleveland

Clinic Foundation, Cleveland, Ohio 44118, USA.

In the past several decades, four prominent theories of chronic

pancreatitis pathogenesis have emerged: the toxic-metabolic theory,

the oxidative stress hypothesis, the stone and duct obstruction

theory, and the necrosis-fibrosis hypothesis. Although these

traditional theories are formulated based on compelling scientific

observations, substantial contradictory data also exist for each.

Furthermore, the basic premises of some of these theories are

directly contradictory. Because of the recent scientific progress in

the underlying genetic, cellular, and molecular pathophysiology,

there have been substantial advances in the understanding of chronic

pancreatitis pathogenesis. This paper will provide an evidence-based

review and critique of the traditional pathogenic theories, followed

by a discussion of the new advances in pancreatic fibrogenesis.

Moreover, we will discuss plausible pathogenic sequences applied to

each of the known etiologies.

Publication Types:

Review

Review, Tutorial

PMID: 15555009 [PubMed - indexed for MEDLINE]

[Guest guest]

Anyse,

Maybe someone does have access. Membership is pretty steep, $175

per year. I checked further and the full article can be purchased

for 30 days, at the cost of $26.00, (credit cards accepted).

It does sound like a fascinating article, and since Dr. Conwell of

the Cleveland Clinic was one of the participating authors, I imagine

it's pretty darn interesting and factual.

Oh well, maybe we have a Medline member in our midst who can get the

full article for us. Interesting subject, isn't it?

With love, hope and prayers,

Heidi

Heidi H. Griffeth

Bluffton, SC

SC State & SE Regional Representative

Pancreatitis Association, International

Note: All comments or advice are personal opinion only, and should

not be substituted for professional medical consultation.