You know it's serious when they talk about the Big C

[Guest guest]

Well, fellow travelers, this is one I would definitely like to read

completely from MedLine. The extenuating factors of CF and CP here

are a bit disconcerting and, being that many of us have had our own

serious attacks and continual problems before turning 50 will also be

interested in this probability. Again, one with access to MedLine, I

would like to get this entire study.

Pancreatitis as a risk for pancreatic cancer.

Whitcomb DC, Pogue-Geile K.

Department of Medicine, University of Pittsburgh, UPMC Presbyterian,

Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213,

USA. whitcomb@...

Chronic pancreatitis clearly predisposes to pancreatic cancer, with

early onset-long duration chronic pancreatitis from cystic fibrosis,

TP, and HP conferring the highest risk. Chronic pancreatitis is not a

critical step, however, but rather one of several conditions that

accelerate the accumulation of critical genetic mutations and

chromosomal losses necessary for carcinogenesis. Indeed, other

germline mutations, environmental factors such as tobacco smoking and

alcohol consumption, or dietary factors may also accelerate the

pathway to carcinogenesis, and may be synergistic with the conditions

created by chronic pancreatitis. Because patients with chronic

pancreatitis are at high risk of pancreatic cancer, the physician is

faced with decisions on how to manage this risk. Discontinuing

smoking and alcohol consumption, and perhaps dietary modification are

obvious recommendations for risk reduction. If, however, the patient

is older and already in a very high-risk category (e.g., long-

standing HP), then screening for cancers must be considered.

Inclusion in multicenter trials is recommended, and information on

ongoing studies can be obtained through the office of Dr. Whitcomb,

or as posted on www.pancreas.org.

Publication Types:

Review

Review, Tutorial

PMID: 12134623 [PubMed - indexed for MEDLINE]

My summary: since no real ages are stated here, this makes no sense

withou such data and there is little that one can reliably draw from

this abstract.

Anyse

[Guest guest]

:-(

Not good news. As if CP was not enough...

Eileen

> Well, fellow travelers, this is one I would definitely like to read

> completely from MedLine. The extenuating factors of CF and CP here

> are a bit disconcerting and, being that many of us have had our