Guest guest Posted August 24, 2005 Report Share Posted August 24, 2005 Well, fellow travelers, (aren't you tired of this intro?) here is another one dealing with digestion and treatment and nutrition and all that. Again, if you have access to MedLine, I would like to get the complete article. Chronic pancreatitis and maldigestion. sen JM, Forsmark CE. Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32610-0214, USA. Patients with chronic pancreatitis may suffer from maldigestion and malnutrition. Longstanding inflammation and fibrosis in the gland can destroy exocrine tissue, leading to inadequate delivery of digestive enzymes to the duodenum in the prandial and postprandial period and subsequent maldigestion. Maldigestion is augmented by inadequate bicarbonate delivery to the duodenum, with secondary inactivation of enzymes and bile acids by gastric acid. Abdominal pain, sitophobia, nausea, vomiting, postprandial satiety, and on-going alcohol abuse may contribute to poor oral intake. Gastric dysmotility and mechanical gastric outlet obstruction from fibrosis in the pancreatic head may contribute to malnutrition and clinical decline. Patients with chronic pancreatitis may at times experience profound steatorrhea and weight loss. In this article, we examine the natural history of exocrine insufficiency in chronic pancreatitis, outline the important nutritional issues in these patients, review the methods of diagnosis of maldigestion, and discuss the approach to therapy. Publication Types: Case Reports Review Review, Tutorial PMID: 12462705 [PubMed - indexed for MEDLINE] Anyse Quote Link to comment Share on other sites More sharing options...
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