MiraLax the next Vioxx?

[Guest guest]

http://www.gutsense.org/gutsense/the-role-of-miralax-laxative-in-autism-deme

ntia-alzheimer.html

Getting mad or forgetful after taking a laxative? Well, according to the US

Food and Drug Administration that¡Çs exactly what certain best-selling

laxatives can do to you.

Back in December of 2011, the FDA placed MiraLAX - a polyethylene

glycol-containing blockbuster drug marketed by Merck & Co - on its Adverse

Event Reporting System (AERS) in connection to ¡Èneuropsychiatric

events.¡É

Besides MiraLAX, this warning also applies to Movicol, Dulcolax, Colyte,

Colovage, Co-Lav, Clensz-Lyte, ClearLax, GoLYTELY, GaviLyte C, GlycoLax,

Go-Evac, GlycoPrep, E-Z-Em Fortrans, Halflytely, Lax-a-Day, LaxLyte,

MoviPrep, Macrogol, NuLytely, OCL, Peg-Lyte, Prep Lyte, Softlax, TriLyte,

and all other brands with Polyethylene Glycol 3350 (PEG for short) as their

active ingredient. The ¡È3350¡É qualifier refers to the molecular

weight of

this particular variant of PEG.

Polyethylene glycol is made by stringing together molecules of ethylene

glycol into a large polymer chain, hence the prefix poly-, Greek for many.

On its own, ethylene glycol is used in automotive antifreeze and brake

fluid. According to the National Institute for Occupational Safety and

Health, it is an extremely toxic substance:

¡ÈEthylene glycol is chemically broken down in the body into toxic

compounds. It and its toxic byproducts first affect the central nervous

system (CNS), then the heart, and finally the kidneys. Ingestion of

sufficient amounts [as little as 30 ml - KM] can be fatal.¡É [2]

The term ¡Èneuropsychiatric events¡É in the FDA's safety alert

refers to

neurologic disorders of the central and peripheral nervous systems such as

autism, dementia, depression, schizophrenia, multiple sclerosis,

Alzheimer¡Ç

s and Parkinson¡Çs diseases, and similar others [3]. These conditions

result

from PEG's direct (through cellular damage) and indirect (through

malnutrition of essential micronutrients) neurotoxicity. No surprise there

considering the quotation above.

Lead, mercury, and arsenic are some of the best known neurotoxins. So are

snake venom, curare, botulinum, and tetanus. PEG is more like lead or

mercury - slow-acting, insidious, and difficult to pin down conclusively

onto a variety of ¡Èslow-brewing¡É neurological disorders.

In addition to neurotoxicity, the following serious complications have been

associated with polyethylene glycol-containing laxatives:

¡ü Nephrotoxicity: PEG has been connected to nephrotoxicity, a euphemism

for

kidney damage [4] and it is counter-indicated for patients with kidney

disease. This particular ¡Èside effect¡É is most likely related to

the

hydrolyzed (separated in water solution) molecules of ethylene glycol.

¡ü Urticaria: PEG may cause allergy-related hives (urticaria) - raised

red

welts on the surface of the skin. Children are particularly susceptible to

hives, and face a grave risk of anaphylaxis - a life-threatening allergic

reaction that may develop within minutes or even seconds after ingesting a

PEG-containing laxative. Links between PEG and urticaria have been

documented as far back as 1991 [link].

¡ü Esophageal perforations: Also known as Mallory-Weiss tear, esophageal

perforations associated with polyethylene glycol electrolyte lavage solution

have been reported as far back as 1991. These tears and related bleedings

may occur in the mucus membrane of the lower part of the esophagus, or upper

part of the stomach [link].

This particular side effect isn't directly related to MiraLAX which is taken

in smaller doses, but the potential is always there, particularly among

young children or patients with GI tract obstruction that may initially

manifest itself as constipation.

All of the ¡Ècollateral damage¡É from PEG shouldn't surprise anyone,

least

of all seasoned chemists, pharmacists, and medical doctors. This industrial

chemical is manufactured by Dow Chemical Company for use in wood treatments,

paints, coatings, rubber, textiles, detergents, and toilet bowl cleaners

[4].

[Guest guest]

Dear God!!!! Best not to buy anything at all!!! Even laxatives!!!!!! Well I never!!!Sent from my iPhone

http://www.gutsense.org/gutsense/the-role-of-miralax-laxative-in-autism-deme

ntia-alzheimer.html

Getting mad or forgetful after taking a laxative? Well, according to the US

Food and Drug Administration that¡Çs exactly what certain best-selling

laxatives can do to you.

Back in December of 2011, the FDA placed MiraLAX - a polyethylene

glycol-containing blockbuster drug marketed by Merck & Co - on its Adverse

Event Reporting System (AERS) in connection to ¡Èneuropsychiatric

events.¡É

Besides MiraLAX, this warning also applies to Movicol, Dulcolax, Colyte,

Colovage, Co-Lav, Clensz-Lyte, ClearLax, GoLYTELY, GaviLyte C, GlycoLax,

Go-Evac, GlycoPrep, E-Z-Em Fortrans, Halflytely, Lax-a-Day, LaxLyte,

MoviPrep, Macrogol, NuLytely, OCL, Peg-Lyte, Prep Lyte, Softlax, TriLyte,

and all other brands with Polyethylene Glycol 3350 (PEG for short) as their

active ingredient. The ¡È3350¡É qualifier refers to the molecular

weight of

this particular variant of PEG.

Polyethylene glycol is made by stringing together molecules of ethylene

glycol into a large polymer chain, hence the prefix poly-, Greek for many.

On its own, ethylene glycol is used in automotive antifreeze and brake

fluid. According to the National Institute for Occupational Safety and

Health, it is an extremely toxic substance:

¡ÈEthylene glycol is chemically broken down in the body into toxic

compounds. It and its toxic byproducts first affect the central nervous

system (CNS), then the heart, and finally the kidneys. Ingestion of

sufficient amounts [as little as 30 ml - KM] can be fatal.¡É [2]

The term ¡Èneuropsychiatric events¡É in the FDA's safety alert

refers to

neurologic disorders of the central and peripheral nervous systems such as

autism, dementia, depression, schizophrenia, multiple sclerosis,

Alzheimer¡Ç

s and Parkinson¡Çs diseases, and similar others [3]. These conditions

result

from PEG's direct (through cellular damage) and indirect (through

malnutrition of essential micronutrients) neurotoxicity. No surprise there

considering the quotation above.

Lead, mercury, and arsenic are some of the best known neurotoxins. So are

snake venom, curare, botulinum, and tetanus. PEG is more like lead or

mercury - slow-acting, insidious, and difficult to pin down conclusively

onto a variety of ¡Èslow-brewing¡É neurological disorders.

In addition to neurotoxicity, the following serious complications have been

associated with polyethylene glycol-containing laxatives:

¡ü Nephrotoxicity: PEG has been connected to nephrotoxicity, a euphemism

for

kidney damage [4] and it is counter-indicated for patients with kidney

disease. This particular ¡Èside effect¡É is most likely related to

the

hydrolyzed (separated in water solution) molecules of ethylene glycol.

¡ü Urticaria: PEG may cause allergy-related hives (urticaria) - raised

red

welts on the surface of the skin. Children are particularly susceptible to

hives, and face a grave risk of anaphylaxis - a life-threatening allergic

reaction that may develop within minutes or even seconds after ingesting a

PEG-containing laxative. Links between PEG and urticaria have been

documented as far back as 1991 [link].

¡ü Esophageal perforations: Also known as Mallory-Weiss tear, esophageal

perforations associated with polyethylene glycol electrolyte lavage solution

have been reported as far back as 1991. These tears and related bleedings

may occur in the mucus membrane of the lower part of the esophagus, or upper

part of the stomach [link].

This particular side effect isn't directly related to MiraLAX which is taken

in smaller doses, but the potential is always there, particularly among

young children or patients with GI tract obstruction that may initially

manifest itself as constipation.

All of the ¡Ècollateral damage¡É from PEG shouldn't surprise anyone,

least

of all seasoned chemists, pharmacists, and medical doctors. This industrial

chemical is manufactured by Dow Chemical Company for use in wood treatments,

paints, coatings, rubber, textiles, detergents, and toilet bowl cleaners

[4].

[Guest guest]

Thanks a lot for sharing this. Today evening, I was planning to buy a box of this one at Costco.It is interesting " FDA decided that no action is necessary at this time based on available information. "

I think I will stick to p psyllium seed powder for time being

 

http://www.gutsense.org/gutsense/the-role-of-miralax-laxative-in-autism-deme

ntia-alzheimer.html

Getting mad or forgetful after taking a laxative? Well, according to the US

Food and Drug Administration that¡Çs exactly what certain best-selling

laxatives can do to you.

Back in December of 2011, the FDA placed MiraLAX - a polyethylene

glycol-containing blockbuster drug marketed by Merck & Co - on its Adverse

Event Reporting System (AERS) in connection to ¡Èneuropsychiatric

events.¡É

Besides MiraLAX, this warning also applies to Movicol, Dulcolax, Colyte,

Colovage, Co-Lav, Clensz-Lyte, ClearLax, GoLYTELY, GaviLyte C, GlycoLax,

Go-Evac, GlycoPrep, E-Z-Em Fortrans, Halflytely, Lax-a-Day, LaxLyte,

MoviPrep, Macrogol, NuLytely, OCL, Peg-Lyte, Prep Lyte, Softlax, TriLyte,

and all other brands with Polyethylene Glycol 3350 (PEG for short) as their

active ingredient. The ¡È3350¡É qualifier refers to the molecular

weight of

this particular variant of PEG.

Polyethylene glycol is made by stringing together molecules of ethylene

glycol into a large polymer chain, hence the prefix poly-, Greek for many.

On its own, ethylene glycol is used in automotive antifreeze and brake

fluid. According to the National Institute for Occupational Safety and

Health, it is an extremely toxic substance:

¡ÈEthylene glycol is chemically broken down in the body into toxic

compounds. It and its toxic byproducts first affect the central nervous

system (CNS), then the heart, and finally the kidneys. Ingestion of

sufficient amounts [as little as 30 ml - KM] can be fatal.¡É [2]

The term ¡Èneuropsychiatric events¡É in the FDA's safety alert

refers to

neurologic disorders of the central and peripheral nervous systems such as

autism, dementia, depression, schizophrenia, multiple sclerosis,

Alzheimer¡Ç

s and Parkinson¡Çs diseases, and similar others [3]. These conditions

result

from PEG's direct (through cellular damage) and indirect (through

malnutrition of essential micronutrients) neurotoxicity. No surprise there

considering the quotation above.

Lead, mercury, and arsenic are some of the best known neurotoxins. So are

snake venom, curare, botulinum, and tetanus. PEG is more like lead or

mercury - slow-acting, insidious, and difficult to pin down conclusively

onto a variety of ¡Èslow-brewing¡É neurological disorders.

In addition to neurotoxicity, the following serious complications have been

associated with polyethylene glycol-containing laxatives:

¡ü Nephrotoxicity: PEG has been connected to nephrotoxicity, a euphemism

for

kidney damage [4] and it is counter-indicated for patients with kidney

disease. This particular ¡Èside effect¡É is most likely related to

the

hydrolyzed (separated in water solution) molecules of ethylene glycol.

¡ü Urticaria: PEG may cause allergy-related hives (urticaria) - raised

red

welts on the surface of the skin. Children are particularly susceptible to

hives, and face a grave risk of anaphylaxis - a life-threatening allergic

reaction that may develop within minutes or even seconds after ingesting a

PEG-containing laxative. Links between PEG and urticaria have been

documented as far back as 1991 [link].

¡ü Esophageal perforations: Also known as Mallory-Weiss tear, esophageal

perforations associated with polyethylene glycol electrolyte lavage solution

have been reported as far back as 1991. These tears and related bleedings

may occur in the mucus membrane of the lower part of the esophagus, or upper

part of the stomach [link].

This particular side effect isn't directly related to MiraLAX which is taken

in smaller doses, but the potential is always there, particularly among

young children or patients with GI tract obstruction that may initially

manifest itself as constipation.

All of the ¡Ècollateral damage¡É from PEG shouldn't surprise anyone,

least

of all seasoned chemists, pharmacists, and medical doctors. This industrial

chemical is manufactured by Dow Chemical Company for use in wood treatments,

paints, coatings, rubber, textiles, detergents, and toilet bowl cleaners

[4].