Simplest suggestions for keeping mgl cells happy?? Re: Immune cells chow down on living brain

[Guest guest]

For that you'd need to move to suburbs with fresh clean air during pregnancy,

and get organic fresh foods:)

The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and

Loss of Dopaminergic Neuron Function.

Levesque S, Taetzsch T, Lull ME, JA, McGraw C, Block ML.

Source

Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical

Campus, Richmond, VA, 23298, USA.

Abstract

Increasing reports support that air pollution causes neuroinflammation and is

linked to central nervous system (CNS) disease/damage. Diesel exhaust particles

(DEP) are a major component of urban air pollution, which has been linked to

microglial activation and Parkinson's disease-like pathology. To begin to

address how DEP may exert CNS effects, microglia and neuron-glia cultures were

treated with either nanometer-sized DEP (<0.22 & #956;M; 50 & #956;g/mL), ultrafine

carbon black (ufCB, 50 & #956;g/ml), or DEP extracts (eDEP; from 50 & #956;g/ml

DEP) and the effect of microglial activation and dopaminergic (DA) neuron

function was assessed. All three treatments showed enhanced amoeboid microglia

morphology, increased H2 O2 production, and decreased DA uptake. Mechanistic

inquiry revealed that the scavenger receptor inhibitor fucoidan blocked DEP

internalization in microglia, but failed to alter DEP-induced H2 O2 production

in microglia. However, pretreatment with the MAC1/CD11b inhibitor antibody

blocked microglial H2 O2 production in response to DEP. MAC1-/- mesencephalic

neuron-glia cultures were protected from DEP-induced loss of DA neuron function,

as measured by DA uptake. These findings support that DEP may activate microglia

through multiple mechanisms, where scavenger receptors regulate internalization

of DEP and the MAC1 receptor is mandatory for both DEP-induced microglial H2 O2

production and loss of DA neuron function

http://www.ncbi.nlm.nih.gov/pubmed/23470120

>

> Cool. Please, if one exists, let us know about a ten most general way-list

to

> keep the peace with microglial cells (even though everyone is genetically

> unique).

>

>

>

> ________________________________

>

> To: stopcallingitautism ;

> stopcallingitautismfordoctors ; GFCFKids ;

> mb12valtrex ; Defeat Autism Now Network

> Sent: Thu, March 7, 2013 11:21:51 PM

> Subject: Immune cells chow down on living brain

>

>

> Another example of why it is extremely important not make the microglial cells

> get mad. The microglia is one of the most amazing cells in your body, but only

> when they are happy and healthy. When they get mad, especially for an extended

> period of time, autism happens. We have to make the microglia happy by calming

> them down to improve autism symptoms and the related medical problems, from

> motor skill disorders, OCD to gut issues.

> Immune cells chow down on living brain

>

http://www.sciencenews.org/view/generic/id/348723/description/Immune_cells_chow_\

down_on_living_brain

>

> “Zombies aren’t the only things that feast on brains. Immune cells called

> microglia gorge on neural stem cells in developing rat and monkey brains,

> researchers report in the March 6, 2013 Journal of Neuroscience. Chewing up

> neuron-spawning stem cells could help control brain size by pruning away

excess

> growth. Scientists have previously linked abnormal human brain size to autism

> and schizophrenia.â€

>

>

> Thanks,

>

> Founder and Director of Stop Calling It Autism!

> http://www.stopcallingitautism.org

> Fax: or (888) SCIA-123

> SCIA Facebook Page

> http://www.facebook.com/pages/Stop-Calling-It-Autism/129069807127007

>