anti nausea/ surgery drug

[Guest guest]

Hey all just received this article from a group for Dani's brain malformation,

but thought someone could use it here too

Deb

NEW YORK (Reuters Health) - For people undergoing surgery, recovery

could be easier with a new anti-nausea drug.

Aprepitant, made by Merck Research Laboratories, reduces the rate of

vomiting during the first 48 hours after open abdominal surgery,

according to a trial reported this week at the meeting of the

American Society of Anesthesiologists in Atlanta.

The drug is already approved by the US Food and Drug Administration

for treatment of chemotherapy-induced nausea and vomiting, and this

study is the first to evaluate aprepitant's use for post-operative

vomiting, Dr. Tong Joo Gan told Reuters Health.

Gan, from Duke University Medical Center in Durham, North Carolina,

and colleagues enrolled nearly 500 patients undergoing general

anesthesia during open abdominal surgery requiring overnight

hospitalization.

The patients were randomly assigned to take a 125-milligram or a 40-

milligram aprepitant pill 1 hour prior to surgery, or were given an

IV dose of another anti-nausea drug ondansetron at the beginning of

surgery.

Ninety-five percent of patients in the 125-milligram aprepitant

group and 90 percent in the 40-milligram group had no vomiting over

24 hours, compared with 74 percent in the ondansetron group.

Corresponding rates of no vomiting by 48 hours were 93 percent, 85

percent and 67 percent.

" For this population that we studied, the typical rate of nausea and

vomiting is 60 percent to 70 percent, " Gan pointed out. " This is the

first time in 10 years that a new class of drug is coming to market

and it seems to work better at preventing vomiting than existing

drugs. "

Aprepitant has minimal side effects, he added, and is longer lasting

than other currently used anti-vomiting drugs.

33yrold husband Joe, was diagnosed with CC in Sept,

resection on Sept 27th 2004

found mets to the abdominal wall lining 3 lymph nodes involved

open wound from infection until Jan 2005

Ileostomy reversal Dec 7th 2004

Chemo regiment begun Jan 2005

5fu/levorican/Oxaplatin/ Avastin added Feb 14 2005 (Happy Valentines

Calcium Magnesium added for the Tingles Feb 28 2005

Ct Scan done March 23rd 2005 , 16 millimeter cyst like object on liver found

April 1 2005 PET scan done awaiting results

April 11 PET SCAN SHOWS

NED!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

May 9 Plateletts are low 75,000

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