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I will be spending all day Wednesday at Emory for tests. If all goes well I will return for a heart cath and then begin the Artemus study. I will also meet my new Dr. At the hospital. I will be the first patient on the trial. As I told my nurse yesterday "one small step for man, one giant leap for mankind". My only hope is that I have something positive to report to this group in a few months.

Wish us luck!!!!!!!!!

Joe

  JOE & JOANIE LAMENSKIE

IPF JAN. 2008

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Good Morning Joe,

I guess I should know, but I don't - what is the Artemus study? Is it a drug trial?

Appreciate the info,

Dorothy-Fayetteville, GA

UIP-7/05

From: Breathe-Support [mailto:Breathe-Support ] On Behalf Of JOE & JOANIE LAMENSKIESent: Tuesday, July 14, 2009 7:52 AMTo: Breathe-Support@yahoogrouSubject: Artemus study

I will be spending all day Wednesday at Emory for tests. If all goes well I will return for a heart cath and then begin the Artemus study. I will also meet my new Dr. At the hospital. I will be the first patient on the trial. As I told my nurse yesterday "one small step for man, one giant leap for mankind". My only hope is that I have something positive to report to this group in a few months.

Wish us luck!!!!!!!!!

Joe

  JOE & JOANIE LAMENSKIE

IPF JAN. 2008

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Joe, A big Huge Thank You for doing this trial. I again will be praying they do find something to give the newbies hope. Can't wait to see how it goes.. Love and Prayers, Peggy IPF 2004, FloridaWorry looks around, Sorry looks back, Faith looks up. I will be spending all day Wednesday at Emory for tests. If all goes well I will return for a heart cath and then begin the Artemus study. I will also meet my new Dr. At the hospital. I will be the first patient on the trial. As I told my nurse yesterday "one small step for man, one giant leap for mankind". My only hope is that I have something positive to report to this group in a few months. Wish us luck!!!!!!!!! Joe   JOE & JOANIE LAMENSKIE IPF JAN. 2008 <53_c_link.gif> <imstp_animation_monkey_en_020908.gif>

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Joe ... you know we wish you luck!

I'll be watching for an update...

MamaSher; 70, IPF 3-06, OR. NasturtiumsDon't fret about tomorrow, God is already there!

Artemus study

I will be spending all day Wednesday at Emory for tests. If all goes well I will return for a heart cath and then begin the Artemus study. I will also meet my new Dr. At the hospital. I will be the first patient on the trial. As I told my nurse yesterday "one small step for man, one giant leap for mankind". My only hope is that I have something positive to report to this group in a few months.

Wish us luck!!!!!!!!!

Joe

  JOE & JOANIE LAMENSKIE

IPF JAN. 2008

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Good Luck, Joe

Toodles

Jane

>

> I will be spending all day Wednesday at Emory for tests. If all goes

well I

> will return for a heart cath and then begin the Artemus study. I will

also

> meet my new Dr. At the hospital. I will be the first patient on the

trial.

> As I told my nurse yesterday " one small step for man, one giant leap

for

> mankind " . My only hope is that I have something positive to report to

this

> group in a few months.

> Wish us luck!!!!!!!!!

> Joe

>

>  

> JOE & JOANIE LAMENSKIE

> IPF JAN. 2008

>

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Hi Joe,

I hope to be starting the Artemus study also in about a week. The U of M (Miami)

is doing the final evaluation of my condition to ensure

that I qualify. I have a prelimenary OK but waiting on some final tests and peer

reviews.

Terre Higgs, IPF 6/08

>

> I will be spending all day Wednesday at Emory for tests. If all goes well I

> will return for a heart cath and then begin the Artemus study. I will also

> meet my new Dr. At the hospital. I will be the first patient on the trial.

> As I told my nurse yesterday " one small step for man, one giant leap for

> mankind " . My only hope is that I have something positive to report to this

> group in a few months.

> Wish us luck!!!!!!!!!

> Joe

>

>  

> JOE & JOANIE LAMENSKIE

> IPF JAN. 2008

>

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Joe, Gods Speed through this testing. Love and Prayers, Peggy IPF 2004, FloridaWorry looks around, Sorry looks back, Faith looks up.  Joe ... you know we wish you luck! I'll be watching for an update... MamaSher; 70, IPF 3-06, OR. NasturtiumsDon't fret about tomorrow, God is already there! Artemus study I will be spending all day Wednesday at Emory for tests. If all goes well I will return for a heart cath and then begin the Artemus study. I will also meet my new Dr. At the hospital. I will be the first patient on the trial. As I told my nurse yesterday "one small step for man, one giant leap for mankind". My only hope is that I have something positive to report to this group in a few months. Wish us luck!!!!!!!!! Joe   JOE & JOANIE LAMENSKIE IPF JAN. 2008 <53_c_link.gif> <imstp_animation_monkey_en_020908.gif>

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Good luck to both Joe and Terre with the Artemus study.

Pink Joyce R (IPF 3/06) IFA 5/09 Pennsylvania

Donate Life Listed 1/09 Inactive 4/09

www.transplantfund.org---

Subject: Re: Artemus studyTo: Breathe-Support Date: Tuesday, July 14, 2009, 2:45 PM

Hi Joe,I hope to be starting the Artemus study also in about a week. The U of M (Miami) is doing the final evaluation of my condition to ensurethat I qualify. I have a prelimenary OK but waiting on some final tests and peer reviews.Terre Higgs, IPF 6/08>> I will be spending all day Wednesday at Emory for tests. If all goes well I> will return for a heart cath and then begin the Artemus study. I will also> meet my new Dr. At the hospital. I will be the first patient on the trial.> As I told my nurse yesterday "one small step for man, one giant leap for> mankind". My only hope is that I have something positive to report to

this> group in a few months. > Wish us luck!!!!!!!! !> Joe> >   > JOE & JOANIE LAMENSKIE> IPF JAN. 2008>

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Sorry but I don't know what the Artemus study is about. Can anyone fill me in with some details?Dorothy- gaUIP 7/05Sent via BlackBerry by AT&TFrom: Joyce T Rosenberg Date: Tue, 14 Jul 2009 17:16:49 -0700 (PDT)To: <Breathe-Support >Subject: Re: Re: Artemus study Good luck to both Joe and Terre with the Artemus study.Pink Joyce R (IPF 3/06) IFA 5/09 Pennsylvania Donate Life Listed 1/09 Inactive 4/09www.transplantfund.orgFrom: higgstk (AT) bellsouth (DOT) net <higgstk (AT) bellsouth (DOT) net>Subject: Re: Artemus studyTo: Breathe-Support Date: Tuesday, July 14, 2009, 2:45 PMHi Joe,I hope to be starting the Artemus study also in about a week. The U of M (Miami) is doing the final evaluation of my condition to ensurethat I qualify. I have a prelimenary OK but waiting on some final tests and peer reviews.Terre Higgs, IPF 6/08>> I will be spending all day Wednesday at Emory for tests. If all goes well I> will return for a heart cath and then begin the Artemus study. I will also> meet my new Dr. At the hospital. I will be the first patient on the trial.> As I told my nurse yesterday "one small step for man, one giant leap for> mankind". My only hope is that I have something positive to report to this> group in a few months. > Wish us luck!!!!!!!! !> Joe> >   > JOE & JOANIE LAMENSKIE> IPF JAN. 2008>

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Hi Dorothy,

The Artemus study is to study the drug ambrisentan. It has been previously

studied for a condition called Pulmonary Arterial Hypertension (PAH).

The consent form states that the study will test whether or not the course of

your IPF disease will be improved with Ambrisentan. The study will be looking at

whether it is safe and works in IPF. it is desdigned to last between 1 to 3 yrs.

Apparently they have had good results in treating PAH with this drug. One of the

first and last things they do in the study is to place a catheter into the right

side of your heart to measure the blood pressure there. Then they test lung

functions on a regular basis. We will have a 2 to 1 chance of getting the

medicine. There are also two dosed being studied.5mg and 10 mg.

If I'm finally Oked and start the study I'll give updates when or if things

occur.

I'll be looking forward to Joe's progress also. Good Luck, Joe.

Terre, IPF 6/08

> >

> > I will be spending all day Wednesday at Emory for tests. If all goes well I

> > will return for a heart cath and then begin the Artemus study. I will also

> > meet my new Dr. At the hospital. I will be the first patient on the trial.

> > As I told my nurse yesterday " one small step for man, one giant leap for

> > mankind " . My only hope is that I have something positive to report to this

> > group in a few months.

> > Wish us luck!!!!!!!! !

> > Joe

> >

> >  

> > JOE & JOANIE LAMENSKIE

> > IPF JAN. 2008

> >

>

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Ambrisentan is known in the US as Letairis and in Europe as Volibrus. It

was approved in June 2007 as a treatment for Pulmonary Hypertension. It

is a Type A Selective Endothelin Receptor Antagonist. The endpoint of

the clinical trials was the change in 6 Minute walk from before to

after.

It's use is much like Tracleer and Revatio and also like both of them it

is now in clinical trials for PF. The primary outcome measure of this

trial is time to death with the secondary measure progression at 48

weeks, so it is a very long term trial. Those in the trial must have

less than 5% honeycombing. The trial is sponsored by the pharmaceutical,

Gilead and the chief investigator is Dr. Raghu.

The biggest risk to date of ambrisentan is liver damage so the liver is

monitored carefully both before and during the test.

> > >

> > > I will be spending all day Wednesday at Emory for tests. If all

goes well I

> > > will return for a heart cath and then begin the Artemus study. I

will also

> > > meet my new Dr. At the hospital. I will be the first patient on

the trial.

> > > As I told my nurse yesterday " one small step for man, one giant

leap for

> > > mankind " . My only hope is that I have something positive to report

to this

> > > group in a few months.

> > > Wish us luck!!!!!!!! !

> > > Joe

> > >

> > >  

> > > JOE & JOANIE LAMENSKIE

> > > IPF JAN. 2008

> > >

> >

>

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Thanks so much really appreciate all the information. This group is an unbelievable source of knowledge and support.

I thank God that I found all of you,

Dorothy, GA

UIP-7/05

From: Breathe-Support [mailto:Breathe-Support ] On Behalf Of Bruce MorelandSent: Wednesday, July 15, 2009 9:58 AMTo: Breathe-Support Subject: Re: Artemus study

Ambrisentan is known in the US as Letairis and in Europe as Volibrus. Itwas approved in June 2007 as a treatment for Pulmonary Hypertension. Itis a Type A Selective Endothelin Receptor Antagonist. The endpoint ofthe clinical trials was the change in 6 Minute walk from before toafter.It's use is much like Tracleer and Revatio and also like both of them itis now in clinical trials for PF. The primary outcome measure of thistrial is time to death with the secondary measure progression at 48weeks, so it is a very long term trial. Those in the trial must haveless than 5% honeycombing. The trial is sponsored by the pharmaceutical,Gilead and the chief investigator is Dr. Raghu.The biggest risk to date of ambrisentan is liver damage so the liver ismonitored carefully both before and during the test.> > >> > > I will be spending all day Wednesday at Emory for tests. If allgoes well I> > > will return for a heart cath and then begin the Artemus study. Iwill also> > > meet my new Dr. At the hospital. I will be the first patient onthe trial.> > > As I told my nurse yesterday "one small step for man, one giantleap for> > > mankind". My only hope is that I have something positive to reportto this> > > group in a few months.> > > Wish us luck!!!!!!!! !> > > Joe> > >> > >  > > > JOE & JOANIE LAMENSKIE> > > IPF JAN. 2008> > >> >>

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