Re: Sjogren's and prednisone

[Guest guest]

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods adding omega 3 fatty acids to the diet maintaining a healthy body weight non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over

prolonged periods of time turned steroids into "scare-oids".

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

[Guest guest]

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

To: Breathe-Support Sent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods adding omega 3 fatty acids to the diet maintaining a healthy body weight non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

[Guest guest]

elisa

the only reason i suggested running is because they didn't know about the six minute walk test

i like the fact that they are not pushing you for a biopsy

prednisone, if it does work, takes time to kick in, at least 2 weeks, maybe more--also depends onthe dose

Pink Joyce R (IPF 3/06) IFA 5/09 Pennsylvania

Donate Life Listed 1/09 Inactive 4/09

www.transplantfund.org---

Subject: Re: Sjogren's and prednisoneTo: Breathe-Support Date: Sunday, August 16, 2009, 11:43 AM

Elisa:

I have not had a biopsy; no one has suggested one and I would not be eager to have one anyway. I am glad to hear that your lungs have improved with treatment; it gives me hope and makes me happy for you.

I am not on Imuran; the docs thought they'd start out with the prednisone and see what happens. I have an appt in a couple of days with the Rheumy, who is to be the "closely following" doc. I don't know what can be learned after two weeks on this stuff, but am eager to find out. I pretty much have headaches for much of the day, and now am going thru afternoon "manic" periods. And I seem to be hungrier. Auggghhhhh!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: "elisacole (AT) yahoo (DOT) com" <elisacole (AT) yahoo (DOT) com>To: "Breathe-Support@ yahoogroups. com" <Breathe-Support@ yahoogroups. com>Sent: Sunday, August 16, 2009 11:22:20 AMSubject: Re: Sjogren's and prednisone

Barbara,

I have Sjogren's that was actually diagnosed after my PF by a month. From a HRCT in July of '08 to another in Nov. '08, my lungs actually improved, inflammation- wise, on 60 mgs. of prednisone. In Feb. of this year, I had tapered down to 5mgs, then 2. after a flare and coughing, I am now back on 10 mgs. I say hang in there, even with nasty side-effects. I wish I hadn't been so eager to get off the meds. Are you also on Imuran? Did you have a biopsy? my doctor says no reason to put me through that knowing autoimmune is obvious cause. Of course, he is same doctor that told me about a "new little test" called the six-minute walk just five months ago. This is a major teaching hospital in Dallas and his specialty is pulmonary fibrosis! I may one day take Bruce's route and go to Chicago, Duke, or Emory to get a second opinion.

Elisa age 53 NSIP/LIP Sjogren's, Raynaud's, April '08Sent from my iPhone

On Aug 15, 2009, at 3:11 PM, Barbara McD <bamny (AT) yahoo (DOT) com> wrote:

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

Oh Barb, That is the prednisone for sure. Anything that you think is not like you.... prednisone. I always go to the weight gain firstbut the aching joints headaches, shakes and so many other things.. then cataracts GGGGG RRR NONONONO Love and Prayers, Peggy IPF 2004, FloridaWorry looks around, Sorry looks back, Faith looks up. Elisa: I have not had a biopsy; no one has suggested one and I would not be eager to have one anyway. I am glad to hear that your lungs have improved with treatment; it gives me hope and makes me happy for you. I am not on Imuran; the docs thought they'd start out with the prednisone and see what happens. I have an appt in a couple of days with the Rheumy, who is to be the "closely following" doc. I don't know what can be learned after two weeks on this stuff, but am eager to find out. I pretty much have headaches for much of the day, and now am going thru afternoon "manic" periods. And I seem to be hungrier. Auggghhhhh! B Barbara McD IPF, Sept 08 Beautiful Western NC Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9 From: "elisacole (AT) yahoo (DOT) com" <elisacole (AT) yahoo (DOT) com>To: "Breathe-Support " <Breathe-Support >Sent: Sunday, August 16, 2009 11:22:20 AMSubject: Re: Sjogren's and prednisone Barbara, I have Sjogren's that was actually diagnosed after my PF by a month. From a HRCT in July of '08 to another in Nov. '08, my lungs actually improved, inflammation- wise, on 60 mgs. of prednisone. In Feb. of this year, I had tapered down to 5mgs, then 2. after a flare and coughing, I am now back on 10 mgs. I say hang in there, even with nasty side-effects. I wish I hadn't been so eager to get off the meds. Are you also on Imuran? Did you have a biopsy? my doctor says no reason to put me through that knowing autoimmune is obvious cause. Of course, he is same doctor that told me about a "new little test" called the six-minute walk just five months ago. This is a major teaching hospital in Dallas and his specialty is pulmonary fibrosis! I may one day take Bruce's route and go to Chicago, Duke, or Emory to get a second opinion. Elisa age 53 NSIP/LIP Sjogren's, Raynaud's, April '08Sent from my iPhone On Aug 15, 2009, at 3:11 PM, Barbara McD <bamny (AT) yahoo (DOT) com> wrote: Thank you very much Beth. I appreciate you! B Barbara McD IPF, Sept 08 Beautiful Western NC Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9 From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone Barb, This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one. We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to. Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower. BethModeratorFibrotic NSIP 06/06 Dermatomyositis 11/08 We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland Clinic. In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation. So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation. An anti-inflammatory toolbox can contain several medications and strategies: pacing activities with rest periods adding omega 3 fatty acids to the diet maintaining a healthy body weight non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn anti malarial drugs such as hydroxychloroquine other medications such as methotrexate corticosteriods such as prednisone Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com: Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids" . Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation. Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages. Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued. The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include: skin thinning acne increased hair growth, or hirsutism cataracts premature atherosclerosis gastritis menstrual disturbances osteoporosis muscle weakness diabetes mellitus high blood pressure increased risk of infection (Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132) MayoClinic.com also has a very good article, found here, that explains prednisone basics. Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

Peggy - I already had glaucoma to start with, so that is another nervous-making thing.

Barbara McD

PF--Sept 08; Sjogren's--Apr 09; Reynaud's--seems like forever

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

To: Breathe-Support Sent: Sunday, August 16, 2009 6:11:47 PMSubject: Re: Sjogren's and prednisoneOh Barb, That is the prednisone for sure. Anything that you think is not like you.... prednisone. I always go to the weight gain first

but the aching joints headaches, shakes and so many other things.. then cataracts GGGGG RRR NONONONO

Love and Prayers, Peggy

IPF 2004, Florida

Worry looks around,

Sorry looks back,

Faith looks up.

Elisa:

I have not had a biopsy; no one has suggested one and I would not be eager to have one anyway. I am glad to hear that your lungs have improved with treatment; it gives me hope and makes me happy for you.

I am not on Imuran; the docs thought they'd start out with the prednisone and see what happens. I have an appt in a couple of days with the Rheumy, who is to be the "closely following" doc. I don't know what can be learned after two weeks on this stuff, but am eager to find out. I pretty much have headaches for much of the day, and now am going thru afternoon "manic" periods. And I seem to be hungrier. Auggghhhhh!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: "elisacole (AT) yahoo (DOT) com" <elisacole (AT) yahoo (DOT) com>To: "Breathe-Support@ yahoogroups. com" <Breathe-Support@ yahoogroups. com>Sent: Sunday, August 16, 2009 11:22:20 AMSubject: Re: Sjogren's and prednisone

Barbara,

I have Sjogren's that was actually diagnosed after my PF by a month. From a HRCT in July of '08 to another in Nov. '08, my lungs actually improved, inflammation- wise, on 60 mgs. of prednisone. In Feb. of this year, I had tapered down to 5mgs, then 2. after a flare and coughing, I am now back on 10 mgs. I say hang in there, even with nasty side-effects. I wish I hadn't been so eager to get off the meds. Are you also on Imuran? Did you have a biopsy? my doctor says no reason to put me through that knowing autoimmune is obvious cause. Of course, he is same doctor that told me about a "new little test" called the six-minute walk just five months ago. This is a major teaching hospital in Dallas and his specialty is pulmonary fibrosis! I may one day take Bruce's route and go to Chicago, Duke, or Emory to get a second opinion.

Elisa age 53 NSIP/LIP Sjogren's, Raynaud's, April '08Sent from my iPhone

On Aug 15, 2009, at 3:11 PM, Barbara McD <bamny (AT) yahoo (DOT) com> wrote:

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

I was waiting for Ms. Peggy's reply on the prednisone!! She hates it more than most!

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

I just can't help it. LOL You know I would run my mouth.. Hate the stuff. Love and Prayers, Peggy IPF 2004, FloridaWorry looks around, Sorry looks back, Faith looks up. I was waiting for Ms. Peggy's reply on the prednisone!! She hates it more than most! Thank you very much Beth. I appreciate you! B Barbara McD IPF, Sept 08 Beautiful Western NC Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9 From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone Barb, This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one. We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to. Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower. Beth Moderator Fibrotic NSIP 06/06 Dermatomyositis 11/08 We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland Clinic. In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation. So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation. An anti-inflammatory toolbox can contain several medications and strategies: pacing activities with rest periods adding omega 3 fatty acids to the diet maintaining a healthy body weight non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn anti malarial drugs such as hydroxychloroquine other medications such as methotrexate corticosteriods such as prednisone Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com: Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids" . Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation. Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages. Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued. The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include: skin thinning acne increased hair growth, or hirsutism cataracts premature atherosclerosis gastritis menstrual disturbances osteoporosis muscle weakness diabetes mellitus high blood pressure increased risk of infection (Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132) MayoClinic.com also has a very good article, found here, that explains prednisone basics. Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

What do you do if your doctor tells you that you will smother to death in a few months if you don't take it?Beverley Joy,71, UIP,NSIP 1-09,Diabetes,Sjogren's,Fibromyalgia Idaho Thank you very much Beth. I appreciate you! B Barbara McD IPF, Sept 08 Beautiful Western NC Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9 From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone Barb, This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one. We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to. Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune

diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower. Beth Moderator Fibrotic NSIP 06/06 Dermatomyositis 11/08 We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and

specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland Clinic. In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation. So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation. An anti-inflammatory toolbox can contain several medications and strategies: pacing activities with rest periods adding omega 3 fatty acids to the diet maintaining a healthy body weight non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn anti malarial drugs such as hydroxychloroquine other medications such as methotrexate corticosteriods such as prednisone Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com: Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis

patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids" . Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung,

kidney, liver, and gastro- intestinal inflammation. Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages. Others, like myself, take prednisone only when my symptoms require it. In

these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued. The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include: skin thinning acne increased hair growth, or hirsutism cataracts premature atherosclerosis gastritis menstrual disturbances osteoporosis muscle weakness diabetes mellitus high blood pressure increased risk of infection (Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132) MayoClinic.com also has a very good article, found here, that explains prednisone basics. Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

peggy and barb

my eye doc checks my eyes every 6 months because of the prednisone

they are changing -- cataracts are forming

Pink Joyce R (IPF 3/06) IFA 5/09 Pennsylvania

Donate Life Listed 1/09 Inactive 4/09

www.transplantfund.org---

Subject: Re: Sjogren's and prednisoneTo: Breathe-Support Date: Sunday, August 16, 2009, 6:17 PM

Peggy - I already had glaucoma to start with, so that is another nervous-making thing.

Barbara McD

PF--Sept 08; Sjogren's--Apr 09; Reynaud's--seems like forever

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

To: Breathe-Support Sent: Sunday, August 16, 2009 6:11:47 PMSubject: Re: Sjogren's and prednisoneOh Barb, That is the prednisone for sure. Anything that you think is not like you.... prednisone. I always go to the weight gain first but the aching joints headaches, shakes and so many other things.. then cataracts GGGGG RRR NONONONO

Love and Prayers, Peggy

IPF 2004, Florida

Worry looks around,

Sorry looks back,

Faith looks up.

Elisa:

I have not had a biopsy; no one has suggested one and I would not be eager to have one anyway. I am glad to hear that your lungs have improved with treatment; it gives me hope and makes me happy for you.

I am not on Imuran; the docs thought they'd start out with the prednisone and see what happens. I have an appt in a couple of days with the Rheumy, who is to be the "closely following" doc. I don't know what can be learned after two weeks on this stuff, but am eager to find out. I pretty much have headaches for much of the day, and now am going thru afternoon "manic" periods. And I seem to be hungrier. Auggghhhhh!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: "elisacole (AT) yahoo (DOT) com" <elisacole (AT) yahoo (DOT) com>To: "Breathe-Support@ yahoogroups. com" <Breathe-Support@ yahoogroups. com>Sent: Sunday, August 16, 2009 11:22:20 AMSubject: Re: Sjogren's and prednisone

Barbara,

I have Sjogren's that was actually diagnosed after my PF by a month. From a HRCT in July of '08 to another in Nov. '08, my lungs actually improved, inflammation- wise, on 60 mgs. of prednisone. In Feb. of this year, I had tapered down to 5mgs, then 2. after a flare and coughing, I am now back on 10 mgs. I say hang in there, even with nasty side-effects. I wish I hadn't been so eager to get off the meds. Are you also on Imuran? Did you have a biopsy? my doctor says no reason to put me through that knowing autoimmune is obvious cause. Of course, he is same doctor that told me about a "new little test" called the six-minute walk just five months ago. This is a major teaching hospital in Dallas and his specialty is pulmonary fibrosis! I may one day take Bruce's route and go to Chicago, Duke, or Emory to get a second opinion.

Elisa age 53 NSIP/LIP Sjogren's, Raynaud's, April '08Sent from my iPhone

On Aug 15, 2009, at 3:11 PM, Barbara McD <bamny (AT) yahoo (DOT) com> wrote:

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

Beverley,

Everyone has to make their own decisions. Peggy has been on prednisone in the past and reacted very badly to it. The prednisone did nothing to help her and it then took months for her to wean off of it. Her experience was completely miserable and since she got no benefit from the prednisone she has very strong negative feelings about it. She has IPF and her disease is not helped by prednisone. Her doctor is not likely to issue an ultimatum like the one you describe. "take it or you'll smother to death in a few months".

I have NSIP and my disease has been helped by prednisone in the past. I've been off of it now for a long time but I will take it again should I need to. There are tons of side effects but I know from past experience that for me they are manageable.

As I said, everyone has to make up their own mind about prednisone and any other medication. Your situation and your body are unique.

By the way, did your doctor actually say that to you? That's pretty awful.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

To: Breathe-Support Sent: Sunday, August 16, 2009 11:10:35 PMSubject: Re: Sjogren's and prednisone

What do you do if your doctor tells you that you will smother to death in a few months if you don't take it?Beverley Joy,71, UIP,NSIP 1-09,Diabetes,Sjogren's,Fibromyalgia Idaho

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

on the other hand, i would be a lot worse without it

so i deal with the side effects

Pink Joyce R (IPF 3/06) IFA 5/09 Pennsylvania

Donate Life Listed 1/09 Inactive 4/09

www.transplantfund.org---

Subject: Re: Sjogren's and prednisoneTo: Breathe-Support Date: Sunday, August 16, 2009, 9:44 PM

I just can't help it. LOL You know I would run my mouth.. Hate the stuff.

Love and Prayers, Peggy

IPF 2004, Florida

Worry looks around,

Sorry looks back,

Faith looks up.

I was waiting for Ms. Peggy's reply on the prednisone!! She hates it more than most!

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into "scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

Messages in this topic (3) ____________ _________ _________ _________ _________ __

[Guest guest]

Beth,The Prednisone was helping in the beginning but I have been progressing so I don't know if it is still helping. The doctor really did tell me that. Right now I don't think I have a doctor. My doctors nurse told the company that I get my diabetic supplies from that I don't have diabetes. They said she did anyhow and they had her name right. I called 3 times and I never got a call back. Today I called the hospital and said that I have a complaint and who do I complain to. She said she would transfer me. She transfered me to an answering machine. I left a message and they never called back. I will call the pulmonary doctor's office tomorrow. The PA there told me he could get me the prescription. That is good but I have never been given an appointment with the new doctor. So I have two doctors I can't talk to and I won't make an appointment

with my PC just to straighten out her mistake. I don't want a doctor where I can't even talk to her nurse.Beverley Joy,71, UIP,NSIP 1-09,Diabetes,Sjogren's,Fibromyalgia Idaho

Thank you very much Beth. I appreciate you!

B

Barbara McD

IPF, Sept 08

Beautiful Western NC

Let us not become weary in doing good, for at the proper time we will reap a harvest if we do not give up. Galatians 6:9

From: Beth <mbmurtha (AT) yahoo (DOT) com>To: Breathe-Support@ yahoogroups. comSent: Saturday, August 15, 2009 2:12:41 PMSubject: Re: Sjogren's and prednisone

Barb,

This is the best "nutshell" info on Sjorgren's and prednisone that I've seen. I copied and pasted it for you below. Remember when you're taking prednisone for the Sjorgren's you are taking on the inflammation in your body. Inflammation is the enemy, that's what causes the damage whether it's your kidneys, your lungs, liver etc. There are other weapons in the toolbox but prednisone is an important one.

We had a member here, Joyce Dalton who had Sjorgren's among other things. She used prednisone and every other trick in the book to keep the disease at bay. She lived much much longer than any of her doctors expected her to.

Whether it will help you is not something you can necessarily predict. But prednisone is known to be effective against these auto-immune diseases where it's effectiveness in the case of IPF or a non-inflammatory based pulmonary fibrosis is much lower.

Beth

Moderator

Fibrotic NSIP 06/06 Dermatomyositis 11/08

We all know that Sjogren's is an inflammatory autoimmune condition, which means that our bodies and specifically white blood cells have mistakenly identified our own tissues as foreign substances. These cranky leukocytes then launch an attack on our own tissues and in doing so, create inflammation. You can refresh your memory about inflammation and it's nasty effects here in this excellent article by the

Cleveland

Clinic.

In Sjogren's Syndrome, this inflammation can affect the saliva glands, the lacrimal glands in the eyelids, and other mucous-secreting glands, resulting in the hallmark dry eye and dry mouth symptoms. Other body-wide symptoms such as significant fatigue and joint pain are caused by inflammation.

So why is an understanding of inflammation important in a discussion about prednisone? Because this medication can be a significant tool used among several other medications to reduce inflammation.

An anti-inflammatory toolbox can contain several medications and strategies:

pacing activities with rest periods

adding omega 3 fatty acids to the diet

maintaining a healthy body weight

non steroidal anti inflammatory drugs such as ibuprofen, asprin, and naproxyn

anti malarial drugs such as hydroxychloroquine

other medications such as methotrexate

corticosteriods such as prednisone

Corticosteroids, or drugs that closely resemble our own hormone cortisol, are a relatively new addition to the anti-inflammatory toolbox, explained here on About.com:

Corticosteroids or glucocorticoids, often just called "steroids", where once thought to be almost miraculous. In 1948, at the Mayo Clinic in Rochester, Minnesota a group of arthritis patients were given daily injections of a corticosteroid. The results were so striking and the improvement so dramatic that it was thought that the "cure" for arthritis had been discovered. However, as the use of corticosteroids expanded over the years, side effects emerged and it was realized that high doses given over prolonged periods of time turned steroids into

"scare-oids"

..

Prednisone was found to have a dramatic anti-inflammatory effect, a valuable asset in dealing with significant and systemic symptoms in Sjogren's, such as lung, kidney, liver, and gastro- intestinal inflammation.

Used judiciously, corticosteroids are a necessary long-term medication for many Sjoggies. However, due to the numerous side effects of these drugs, careful monitoring is required when prednisone is taken over long periods of time or at high dosages.

Others, like myself, take prednisone only when my symptoms require it. In these instances, Dr. S. prescribes a "burst and taper" dosage, meaning an inital dose followed by gradually smaller amounts of the drug until the medication is discontinued.

The side effects of corticosteroids are the limiting factor in prescribing this powerful drug. Some of the side effects include:

skin thinning

acne

increased hair growth, or hirsutism

cataracts

premature atherosclerosis

gastritis

menstrual disturbances

osteoporosis

muscle weakness

diabetes mellitus

high blood pressure

increased risk of infection

(Information taken from The New Sjogren's Syndrome Handbook edited by J. Wallace, MD, pgs 131-132)

MayoClinic.com also has a very good article, found here, that explains prednisone basics.

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