Re: Reducing dosage during a campaign

[Guest guest]

>

> Hello all,

>

> I'm curious if anyone has any opinion on the advisability of

reducing

> a dosage of DMSA during the middle of a campaign?

TK--- can be done if you really run into trouble but not generally

recommended as it will increase redistribution. Better to follow the

general guidlines to prevent it.

>

> I made the mistake of trying my most recent campaign with double the

> dosage of DMSA from my previous campaign. I went from 100mg to

200mg

> (1.5 months in, no ALA yet).

TK--- I would suggest that if you are 3 months or more past amalgam

removal to start the ALA with the dmsa instead of increasing the dmsa.

I know this was a bad idea for several

> reasons: 100mg is already a really high dose and I'm increasing by

> more than 50% from my previous dose, which Cutler says not to do.

TK--- correct

I

> honestly don't know why I thought to do this. I was doing so well

for

> so long on 100mg, which was the only increment I had, but obviously

I

> should have just stuck with it.

>

> Anyway, it's done now, and now I'm experiencing vastly increased

> headaches, shakiness, and general extreme malaise after just over 24

> hours of the campaign. I was thinking, since I haven't actually

> missed any doses, I might actually be better off if I just lower my

> dose down to 100mg and finish the campaign rather than stop it

> completely right now and suffer the (sure to be unpleasant)

> consequences right away. I took only 100 mg for my last dose and

I'm

> going to try keeping it at 100 mg overnight tonight for both

doses. I

> just thought I'd put this out there and see if anyone else has tried

> it and has any advice.

TK--- not generally recommended as it increases redistribution

especially with such a large dosage. Better to not increase dosage

the way it happened. Start ALA with Dmsa at this point if possible

instead of increasing DMSA.

I'll post my results tomorrow to add to the

> collective knowledge here.

>

> Thanks all!

> .

>

[Guest guest]

In frequent-dose-chelation jrepp330 wrote:

Hello all,

I'm curious if anyone has any opinion on the advisability of reducing

a dosage of DMSA during the middle of a campaign?

---------As TK said, not generally recommended.--------Jackie

I made the mistake of trying my most recent campaign with double the

dosage of DMSA from my previous campaign. I went from 100mg to 200mg

-----------I think TK answered most of your questions, but the other thing

that came to my mind is that Andy recommends starting with 1/8 -1/2 mg/lb, and

not to exceed 1 mg/lb for your highest dose, after building up to that. So I'm

just curious if you fall within those ranges, or if you exceeded the recommended

maximum dose.-----------Jackie

------------If you went from 100mg to 200mg because you only had 100mg

capsules, then there are 25mg capsules available in the links section. But I

also agree with TK, that if you tolerate that high of a dose of DMSA, then I

would work on adding in the ALA when you can, instead of pushing the DMSA any

higher. TK has said so many times that people get in trouble when they try to

go too fast.----------Jackie

(1.5 months in, no ALA yet). I know this was a bad idea for several

reasons: 100mg is already a really high dose and I'm increasing by

more than 50% from my previous dose, which Cutler says not to do. I

honestly don't know why I thought to do this. I was doing so well for

so long on 100mg, which was the only increment I had, but obviously I

should have just stuck with it.

-------------Yes, Andy has said that too, when you find a dose that is good

for you, stick with it for a long time. If you're doing well at 100mg, then

stay there until your 3 months are up and you can add in ALA.----------Jackie

Anyway, it's done now, and now I'm experiencing vastly increased

headaches, shakiness, and general extreme malaise after just over 24

hours of the campaign.

------------This is an excellent example of too high of doses causing

redistribution and new and/or much worse symptoms. I hope everyone takes heed

of this, so they can understand why we push and push to use low doses on a

proper protocol and not to get in a hurry. It's just not worth it, IMO.

And as Andy has stated before, symptoms increase linearly, so double the dose

double the symptoms, but you only increased your mercury excretion by less than

the square root, so something like 30-ish % if I remember right? So that's why

he says its just not worth the extra symptoms for the small gain in excretion

you get from doubling your dose.-----------Jackie

I was thinking, since I haven't actually

missed any doses, I might actually be better off if I just lower my

dose down to 100mg and finish the campaign rather than stop it

completely right now and suffer the (sure to be unpleasant)

consequences right away. I took only 100 mg for my last dose and I'm

going to try keeping it at 100 mg overnight tonight for both doses. I

just thought I'd put this out there and see if anyone else has tried

it and has any advice. I'll post my results tomorrow to add to the

collective knowledge here.

------------Yes, I would like to hear how you did/do with the dosage decrease

during the round, and very curious about your end-of-round symptoms, especially

compared to your other rounds. Thanks.----------Jackie

Thanks all!

.

[Guest guest]

> ------------Yes, I would like to hear how you did/do with the

dosage decrease during the round, and very curious about your

end-of-round symptoms, especially compared to your other rounds.

Thanks.----------Jackie

Jackie,

I'm now 24 hours past my last dose of this campaign. I usually get my

worst redistribution symptoms about now. I know most people on DMSA

get the symptoms about 6 hours after they stop. Perhaps I have slow

liver metabolism? Anyway my symptoms at this end-of-campaign have

been surprisingly mild, probably the easiest I've had yet. I'm

experiencing impaired thinking, motor control issues, fatigue, and a

pounding head, but not significantly more than what is normal for me

on DMSA or off.

Perhaps I headed off some of the worst of the redistribution by

lowering my dose mid-campaign, perhaps not? Either way I obviously

don't really recommend this. The best answer of course is to not do

such a high dose in the first place and never make a dosage jump that

large. I've learned my lesson and will stick to a lower dose from now

on.

Thanks again for your advice,

.