Lack of Sweating; Was: Does TMG increase stomach acid? - Dean.

[Guest guest]

Dean - AI p.49:

" Acetylcholine levels are reduced (possibly due to D_2 receptor stimulation).

This causes difficulty in voluntary muscle contraction, vagus nerve reduction

of heart rate, memory and cognition (cholinergic agents help in alzheimer's

disease), regulation of mucus secretion, and regulating the iris of the eye.

" Some people respond to reduced acetylcholine levels by upregulating their M1

muscarinic acetylcholine receptors. This makes the process that particular

receptor participates in adequately sensitive to the small amounts of remaining

acetylcholine to continue to function. These people will react poorly to

acethycholine boosters like DMAE. They will usually benefit greatly from

methylating agents like SAMe. Thiamine desensitizes the M1 acetylcholine

receptors and brings them back into balance with the other receptors. One of

the things the M1 receptors do is inhibit sweating, so such people often will

not sweat .... It also causes arachidonic acid release, ... Arachidonic acid

in turn increases acetylcholine levels, so such people can end up in a positive

feedback loop which renders them hypersensitive. They often have multiple

chemical sensitivities, and are sensitive to supplements at extremely low

doses. "

So, it looks like he is suggesting thiamine. I've looked for dose levels, but

could never find any suggestions.

Dave.

---------

Posted by: " DeanNetwork " dean@... deansta22

Mon Jun 23, 2008 1:23 pm (PDT)

>An ACh (acetylcholine) precursor is, simply, something that converts

>into acetylcholine within the body. Some examples include 1) choline

>(as bitartrate, chloride, or citrate), 2) DMAE/centrophenoxine, 3)

>phosphatidylcholine (a constituent of lecithin), 4) CDP-choline, and

>5) alpha-GPC. The first one does not cross the BBB (blood brain

>barrier) very well and is also the most likely to produce GI issues.

Hi ,

Thanks for this knowledgable email. I wonder if you know if lack of sweating

has anything to do with ACh (as I belive I read somewhere once in ANdy's

book)?

And how could I treat this?

With low temperatures I have not sweated with ease for some years. I know

this has hampered my mercury excretion. Though my low temperatures are

thyroid related mostly and I am addressing that with the 's protocol,

I have often suspected ACh to have a part to play in the process when I came

accross it in texts before.

I would like my body to sweat more, as I believe it is so essential to

excretion. If I excercise I can bring on a sweat, and of course a sauna

helps.

My adrenal problems have requested lots of salt and I feel better on it.

When I take some sea salt in water (in summer) I sweat with far greater

ease, salty licorice has an even greater effect (because it causes increased

aldosterone activity, salt-retaining hormone).

I just thought you mighy have an answer for me in how ACh and sweating are

linked?

Thanks,

DeanSA

[Guest guest]

It would be nice to know if benfotiamine accomplishes the same thing

(as thiamine) in regards to M1 receptor desensitization, since this

fat-soluble version of B1 has a longer half-life, is more

bioavailable, and has a greater anti-glycation effect.

>

> Dean - AI p.49:

>

> " Acetylcholine levels are reduced (possibly due to D_2 receptor

stimulation).

> This causes difficulty in voluntary muscle contraction, vagus nerve

reduction

> of heart rate, memory and cognition (cholinergic agents help in

alzheimer's

> disease), regulation of mucus secretion, and regulating the iris of

the eye.

>

> " Some people respond to reduced acetylcholine levels by

upregulating their M1

> muscarinic acetylcholine receptors. This makes the process that

particular

> receptor participates in adequately sensitive to the small amounts

of remaining

> acetylcholine to continue to function. These people will react

poorly to

> acethycholine boosters like DMAE. They will usually benefit

greatly from

> methylating agents like SAMe. Thiamine desensitizes the M1

acetylcholine

> receptors and brings them back into balance with the other

receptors. One of

> the things the M1 receptors do is inhibit sweating, so such people

often will

> not sweat .... It also causes arachidonic acid release, ...

Arachidonic acid

> in turn increases acetylcholine levels, so such people can end up

in a positive

> feedback loop which renders them hypersensitive. They often have

multiple

> chemical sensitivities, and are sensitive to supplements at

extremely low doses. "

>

> So, it looks like he is suggesting thiamine. I've looked for dose

levels, but

> could never find any suggestions.

>

> Dave.

>

>