Re: DHEA supplementation causing temperature to drop

[Guest guest]

You may be heavily aromatizing DHEA metablites into estrogens (which

have been shown to lower the thermoregulatory operating point) and,

thereby, exacerbating an already existing estrogen/progesterone

imbalance. I can suggest three ways of investigating this

probability: 1)Try pregnenolone instead, as it can elevate

progesterone (which tends to elevate temperature) as well as

estrogens, 2)use DHEA along with a selective aromatase inhibitor (eg.

letrozole or anastrozole) to prevent the estrogen elevation, and 3)

substitute ordinary DHEA for 7-keto DHEA (which has no steroid

precursor activity). With option 1, you may still need an aromatase

inhibitor since excessively elevated estrogens can only be partially

compensated for with progesterone. Please let me know if you need

clarification on anything I discussed.

>

> I have adrenal fatigue in the stage of high cortisol/low DHEA

>

> My body temperature has been low but has been getting up to 98.6

> almost everyday. When I supplement DHEA 50mg 2x/day, or any DHEA at

> all 25mg 1x/day my temperature goes lower and barely makes it a

little

> above 98.3 or so in the afternoon.

>

> What is up with that?

>

> I was previously having a wierd reaction and passing out/falling

> asleep on DHEA, but I found out it was a Phase II liver sulfation

> problem and since I've been taking glucosamine sulfate and 1mg

> molybdenum daily I haven't been having any adverse effects, except

> body temperature slightly lower.

>

> Anyone have any ideas?

>

[Guest guest]

, thanks for your generous reply. It helped me a lot. I just

have a couple questions:

I have been trying 7 KETO DHEA with no problems, low temperature or any.

I was wondering though, since I have low DHEA levels/high cortisol due

to adrenal fatigue will 7 KETO DHEA provide the same anti-catabolic

protection from cortisol as regular DHEA? Will 7KETO also help rest

my adrenals and help adrenal fatigue like regular DHEA?

Also, I have been taking Chrysin(from LEF:SuperMiraForte) to try to

boost my testosterone(I have very low levels). Chrysin is supposed to

be a mild aromatase inhibitor, I wonder why that would not help what I

was going through?

What do you think about using clomid or nolvadex to prevent

aromatization as well as boost testosterone levels?

[Guest guest]

If your DHEA is low, and subsequently your production of metabolites

such as 4-Androstenediol and testosterone (which serve to counter

cortisol's catabolic effects) are sub-normal, then you will deride

greater protection (against cortisol) from DHEA than 7-keto. Now, 7-

keto does suppress cortisol release, like DHEA, so it will still

help.

Because both 7-keto and ordinary DHEA prevent adrenal overactivity,

they are both adrenal supportive - some have speculated that frequent

dosing with 7-keto provides a more consistent cortisol lowering

effect, so taking it every 3-4 hrs with your chelator(s) seems

reasonable. Also, there is research suggesting that Relora improves

the DHEA/cortisol ratio. Also, many have found high doses(800 mg) of

phosphatidylserine (preferably in two divided doses, early in the day)

to be very helpful in normalizing cortisol levels by improving

cortisol receptor sensitivity i.e., the body's recognition of

cortisol). Others have noticed adequate improvement from more cost

effective quantities on the order of 200-300mg/day.

Unfortunately, chrysin demonstrates poor bioavailability, so, even

though it works well in vitro (a test tube), it's effects aren't

clinically signifigant in humans. In the supplement realm, my

favorite agents for the purposes of improving estrogen metabolism are

DIM (diindolemethane) and Iodoral, but, oftentimes, the selective

pharmaceutical aromatase inhibitors anastrozole or letrozole are

necessary when estradiol levels are elevated (these are available

from overseas pharmacies for those with uncooperative/uninformed

doctors). The trick with these compounds is to closely monitor

estradiol levels, use only the minimum required dosage, and be

prepared to raise the dose when the body upregulates aromatase levels

to try and override the effects of the drug - there is a ceiling

(i.e., the body can only try to overcome what the drugs are

accomplishing to an extent, so dosage increases, again only as much

as is necessary, will address the body's compensatory attempts quite

nicely).

Clomid and Nolvadex aren't actually aromatase inhibitors (which would

serve to decrease the formation of estrogens), but rather estrogen

receptor antagonists (i.e. blockers). They do " address " elevated

estrogens, but not as directly/well as aromatase inhibitors. They

can also imitate estrogens in some areas of the body - there is

actually some evidence that they can encourage the growth of estrogen

dependant tumors which are the very thing they've been prescribed to

treat.

Hope this helps,

>

> , thanks for your generous reply. It helped me a lot. I

just

> have a couple questions:

>

> I have been trying 7 KETO DHEA with no problems, low temperature or

any.

> I was wondering though, since I have low DHEA levels/high cortisol

due

> to adrenal fatigue will 7 KETO DHEA provide the same anti-catabolic

> protection from cortisol as regular DHEA? Will 7KETO also help rest

> my adrenals and help adrenal fatigue like regular DHEA?

>

> Also, I have been taking Chrysin(from LEF:SuperMiraForte) to try to

> boost my testosterone(I have very low levels). Chrysin is supposed

to

> be a mild aromatase inhibitor, I wonder why that would not help

what I

> was going through?

>

> What do you think about using clomid or nolvadex to prevent

> aromatization as well as boost testosterone levels?

>