Guest guest Posted September 18, 2008 Report Share Posted September 18, 2008 In frequent-dose-chelation petshopgirl6 wrote: I'm hoping that perhaps (mercurybeater) and beigetable can chime in, as they wrote in replies with their experiences using DMPS every 3 hours (as well as anyone else, of course)... ----------I also found that 8 hours was way too long, and I usually dose every 5-6 hours now, but I haven't tried more frequent than that yet. So this discussion has made me think of trying something lower, like maybe 4 hours, and see how I do.---------Jackie After having read your replies, I'm now considering taking DMPS more frequently during rounds, possibly even up to every 3 hours like you, as an " experiment " to see how I feel and if there seems to be less side effects/redistribution going on then. ----------It's always ok to try more frequent dosing, to see how you do. Stretching it out farther than the half life is what is bad and is never recommended. The thing to remember is that this will increase your total chelator intake for the day, and you may have to reduce your individual dosages, if you feel like its too much.----------Jackie I was wondering if there were any possible negatives, or risks, to doing this? (eg. is it more taxing on the adrenals or liver, to take it so frequently?). B/c I understand the standard procedure (and what Cutler recommends) is taking it every 6 to 8 hours. ----------I think it would be more taxing if the total chelator for the day reached an amount that was just too much for your body to handle. So if you went from 8 hour dosing to 4 hour dosing, and took 10mg each time, you would essentially be doubling your total mg taken in a day by doing this. So that's what I would be concerned about. Otherwise, the more frequently you take a chelator, the more level your blood level will be, and that should be a good thing.--------Jackie I've completed 4 rounds -- I used 10mg DMPS every 6 hours, 3 days on and 3 days off. I thought 10mg was quite a low starting dose and so probably safe, but by the 4th round, I got bad side effects and even stopped for 3 weeks to take a break. I'm now set to resume chelating again, and am trying to figure out my dosing game plan... (BTW, in retrospect, I don't think it was the 10mg dosage that was so much the problem as the 3 days on, 3 days off schedule. I think I need to take a lot more time off after rounds than the 3 standard days. Is this common?) ----------This certainly varies by person, and some do need more time off. Many do 3 on/4 off, so it's the same days weekly that they are chelating, and some do 3 on/11 off, to do it every other week. And people probably do every other imaginable thing in between. My chelation schedule is often dictated by my personal life/schedule, so is not always consistent, but I also don't start a round if I don't feel up to it either.----------Jackie My plan had been to reduce the dosage to a very low 5mg, taken every 6 hours, 3 days on, and longer days off (anywhere from 5 days to 2 weeks off, depending on how I felt). How does this sound? ----------That would be a reasonable thing to try. It does take some experimenting in the beginning to find out what works best for *you*. And that is the key, it has to work for you, not for someone else.-------Jackie But now, I'm even considering taking it more frequently during the day... if so, should I lower the dosage accordingly? Eg., instead of 5mg every 6 hours, do it 2.5mg every 3 hours? (if I could even widdle it down to that little!) Or maybe 4mg every 4 hours?... Any advice would be greatly appreciated! -----------I guess my suggestion would be to try the 5mg every 6 hours, and see how you do. Even during the round, you could try lowering it to 5 hours, but keep the dose the same, or even 4 hours, and see if it feels better than the 6 hours. It is ok to take it more frequently during a round, you just don't want to do lots of changes during any one round. And since you handled 10mg ok, I'm guessing that 5mg should be ok for you, and hopefully you won't have to go lower than that, even with more frequent dosing. JMO--------Jackie PS. Not that I've done any tests or anything to confirm this, but I believe I'm also a fast phase 1 liver metabolizer, in case that makes any difference. -----------Then that could mean that you will do better with more frequent dosing, and it is always worth trying.---------Jackie Suzanne <snip> Quote Link to comment Share on other sites More sharing options...
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