Re: Smoking.... 4 more abstracts

[Guest guest]

J Pediatr 1992 Feb;120(2 Pt 1):261-4 Related Articles, Links

Association of poor clinical status and heavy exposure to tobacco

smoke in patients with cystic fibrosis who are homozygous for the

F508 deletion.

PW 3rd, RA, BT, Krishnamani MR, JA

3rd.

Department of Pediatrics, Vanderbilt University Medical School,

Nashville, Tennessee 37232-2586.

We examined the association between clinical status and exposure to

tobacco smoke in 44 patients homozygous for the F508 cystic fibrosis

mutation. Heavy exposure to tobacco smoke was significantly

associated with lower Shwachman scores, poorer results of pulmonary

function tests, and a fivefold increase in the number of pulmonary-

related hospitalizations during the previous year.

PMID: 1735823 [PubMed - indexed for MEDLINE]

***************

Respir Med 1990 Jul;84(4):289-91 Related Articles, Links

Passive smoking in cystic fibrosis.

Gilljam H, Stenlund C, sson-Hollsing A, Strandvik B.

Department of Lung Medicine, Karolinska Institute, Huddinge

University Hospital, Stockholm, Sweden.

The families of 32 children with cystic fibrosis (CF) were

interviewed about both their tobacco consumption and their childrens

physical activities. Hospital records informed about treatment

frequency, lung function and clinical score. Cystic fibrosis families

smoked far more than the Swedish average and the passive smokers

among our patients seemed to fare less well in all parameters. The

children of smoking mothers required significantly longer periods of

intravenous antibiotic treatment (P greater than 0.05). Frequent

physical exercise seemed to compensate for the potential harmful

effects of passive smoking and children with high physical activity

living in families who smoked needed significantly less frequent

antibiotic treatment than the inactive children (P greater than

0.02). Although this series is small, the results indicate that a

smoke-free environment may be important for CF patients. General

information is insufficient and extensive psychological support to

the families is probably necessary.

PMID: 2236755 [PubMed - indexed for MEDLINE]

***************

N Engl J Med 1990 Sep 20;323(12):782-8 Related Articles, Links

Comment in:

N Engl J Med. 1990 Sep 20;323(12):823-5.

Exposure of children with cystic fibrosis to environmental tobacco

smoke.

Rubin BK.

University of Alberta Hospitals, Department of Pediatrics

(Pulmonary), Edmonton, Canada.

BACKGROUND. In children, passive exposure to environmental tobacco

smoke has been associated with growth suppression and an increased

frequency of respiratory tract infections. On the assumption that

this association would be more pronounced in children with chronic

pulmonary disease, we examined the growth, nutritional status, lung

function, and clinical condition of children with cystic fibrosis in

relation to their exposure to environmental tobacco smoke. METHODS.

We studied 43 children (age, 6 to 11 years) on entry to a summer camp

and then again after two weeks in this smoke-free environment. Twenty-

four of the children (56 percent) came from homes with smokers.

RESULTS. There appeared to be a dose-dependent relation between the

estimate of smoke exposure (cigarettes smoked per day in the home)

and overall severity of disease, as assessed by the age-adjusted rate

of hospital admissions (r = 0.58), peak expiratory flow rate (r = -

0.39), and measures of growth and nutrition, including weight

percentile (r = -0.37), height percentile (r = -0.44), midarm

circumference (r = -0.42), and triceps skin-fold thickness (r = -

0.31). These effects were most evident in the girls. When only the 24

children from homes with smokers were analyzed, however, the dose-

dependent relation was present only for the number of hospital

admissions and for height. Among the children with good lung function

(n = 21) or with normal weight for height (n = 27) at the start of

camp, those who had been exposed to tobacco smoke gained

significantly more weight during the two weeks of camp than did the

children from smoke-free homes. CONCLUSIONS. These data suggest that

passive exposure to tobacco smoke adversely affects the growth and

health of children with cystic fibrosis, although the possibility

cannot be ruled out that social, economic, or other factors

determined both the smoking status of the household and the

nutritional status of the children.

PMID: 2392132 [PubMed - indexed for MEDLINE]

**************

Am Rev Respir Dis 1993 Nov;148(5):1266-71 Related Articles, Links

Passive smoking and lung function in cystic fibrosis.

Kovesi T, Corey M, Levison H.

Pulmonary Division, Hospital for Sick Children, Toronto, Ontario,

Canada.

The relationship between passive exposure to cigarette smoking and

objective measures of health was examined in 340 patients with cystic

fibrosis attending a large hospital-based clinic. Patients who came

from households with smokers did not differ from those living in

smoke-free households in terms of nutritional status, clinical

scores, spirometry, or colonization with Pseudomonas. The number of

cigarettes smoked in the household was not significantly related to

nutritional status, clinical score, spirometry, or hospitalization.

Similar results were found when children 6 to 11 yr of age were

analyzed separately, except that height percentile was negatively

related to the number of cigarettes smoked in the household. The

effects of household exposure to cigarette smoke were further

evaluated by analyzing changes in nutritional status, clinical score,

and spirometry over a 15-yr period among patients whose families

never, always, stopped, or started smoking during this time. Height

percentile increased slightly during this interval among those whose

households never smoked, whereas no change occurred among patients

whose households always smoked, and a decline was seen among patients

whose households quit. These differences were statistically

significant. Patients whose households never smoked had consistently

higher pulmonary function measurements than did patients whose

families always smoked, although the differences were not

statistically significant. The rates of decline were similar in these

two groups. Patients whose households stopped smoking had

significantly lower pulmonary functions at the end of the study than

did subjects whose households never smoked.(ABSTRACT TRUNCATED AT 250

WORDS)

PMID: 8239163 [PubMed - indexed for MEDLINE]

[Guest guest]

thank you for the articles.

Re: Smoking.... 4 more abstracts

> J Pediatr 1992 Feb;120(2 Pt 1):261-4 Related Articles, Links

>

>

> Association of poor clinical status and heavy exposure to tobacco

> smoke in patients with cystic fibrosis who are homozygous for the

> F508 deletion.

>

> PW 3rd, RA, BT, Krishnamani MR, JA

> 3rd.

>

> Department of Pediatrics, Vanderbilt University Medical School,

> Nashville, Tennessee 37232-2586.

>

> We examined the association between clinical status and exposure to

> tobacco smoke in 44 patients homozygous for the F508 cystic fibrosis

> mutation. Heavy exposure to tobacco smoke was significantly

> associated with lower Shwachman scores, poorer results of pulmonary

> function tests, and a fivefold increase in the number of pulmonary-

> related hospitalizations during the previous year.

>

> PMID: 1735823 [PubMed - indexed for MEDLINE]

> ***************

>

> Respir Med 1990 Jul;84(4):289-91 Related Articles, Links

>

>

> Passive smoking in cystic fibrosis.

>

> Gilljam H, Stenlund C, sson-Hollsing A, Strandvik B.

>

> Department of Lung Medicine, Karolinska Institute, Huddinge

> University Hospital, Stockholm, Sweden.

>

> The families of 32 children with cystic fibrosis (CF) were

> interviewed about both their tobacco consumption and their childrens

> physical activities. Hospital records informed about treatment

> frequency, lung function and clinical score. Cystic fibrosis families

> smoked far more than the Swedish average and the passive smokers

> among our patients seemed to fare less well in all parameters. The

> children of smoking mothers required significantly longer periods of

> intravenous antibiotic treatment (P greater than 0.05). Frequent

> physical exercise seemed to compensate for the potential harmful

> effects of passive smoking and children with high physical activity

> living in families who smoked needed significantly less frequent

> antibiotic treatment than the inactive children (P greater than

> 0.02). Although this series is small, the results indicate that a

> smoke-free environment may be important for CF patients. General

> information is insufficient and extensive psychological support to

> the families is probably necessary.

>

> PMID: 2236755 [PubMed - indexed for MEDLINE]

> ***************

>

> N Engl J Med 1990 Sep 20;323(12):782-8 Related Articles, Links

>

>

> Comment in:

> N Engl J Med. 1990 Sep 20;323(12):823-5.

>

> Exposure of children with cystic fibrosis to environmental tobacco

> smoke.

>

> Rubin BK.

>

> University of Alberta Hospitals, Department of Pediatrics

> (Pulmonary), Edmonton, Canada.

>

> BACKGROUND. In children, passive exposure to environmental tobacco

> smoke has been associated with growth suppression and an increased

> frequency of respiratory tract infections. On the assumption that

> this association would be more pronounced in children with chronic

> pulmonary disease, we examined the growth, nutritional status, lung

> function, and clinical condition of children with cystic fibrosis in

> relation to their exposure to environmental tobacco smoke. METHODS.

> We studied 43 children (age, 6 to 11 years) on entry to a summer camp

> and then again after two weeks in this smoke-free environment. Twenty-

> four of the children (56 percent) came from homes with smokers.

> RESULTS. There appeared to be a dose-dependent relation between the

> estimate of smoke exposure (cigarettes smoked per day in the home)

> and overall severity of disease, as assessed by the age-adjusted rate

> of hospital admissions (r = 0.58), peak expiratory flow rate (r = -

> 0.39), and measures of growth and nutrition, including weight

> percentile (r = -0.37), height percentile (r = -0.44), midarm

> circumference (r = -0.42), and triceps skin-fold thickness (r = -

> 0.31). These effects were most evident in the girls. When only the 24

> children from homes with smokers were analyzed, however, the dose-

> dependent relation was present only for the number of hospital

> admissions and for height. Among the children with good lung function

> (n = 21) or with normal weight for height (n = 27) at the start of

> camp, those who had been exposed to tobacco smoke gained

> significantly more weight during the two weeks of camp than did the

> children from smoke-free homes. CONCLUSIONS. These data suggest that

> passive exposure to tobacco smoke adversely affects the growth and

> health of children with cystic fibrosis, although the possibility

> cannot be ruled out that social, economic, or other factors

> determined both the smoking status of the household and the

> nutritional status of the children.

>

> PMID: 2392132 [PubMed - indexed for MEDLINE]

> **************

>

> Am Rev Respir Dis 1993 Nov;148(5):1266-71 Related Articles, Links

>

>

> Passive smoking and lung function in cystic fibrosis.

>

> Kovesi T, Corey M, Levison H.

>

> Pulmonary Division, Hospital for Sick Children, Toronto, Ontario,

> Canada.

>

> The relationship between passive exposure to cigarette smoking and

> objective measures of health was examined in 340 patients with cystic

> fibrosis attending a large hospital-based clinic. Patients who came

> from households with smokers did not differ from those living in

> smoke-free households in terms of nutritional status, clinical

> scores, spirometry, or colonization with Pseudomonas. The number of

> cigarettes smoked in the household was not significantly related to

> nutritional status, clinical score, spirometry, or hospitalization.

> Similar results were found when children 6 to 11 yr of age were

> analyzed separately, except that height percentile was negatively

> related to the number of cigarettes smoked in the household. The

> effects of household exposure to cigarette smoke were further

> evaluated by analyzing changes in nutritional status, clinical score,

> and spirometry over a 15-yr period among patients whose families

> never, always, stopped, or started smoking during this time. Height

> percentile increased slightly during this interval among those whose

> households never smoked, whereas no change occurred among patients

> whose households always smoked, and a decline was seen among patients

> whose households quit. These differences were statistically

> significant. Patients whose households never smoked had consistently

> higher pulmonary function measurements than did patients whose

> families always smoked, although the differences were not

> statistically significant. The rates of decline were similar in these

> two groups. Patients whose households stopped smoking had

> significantly lower pulmonary functions at the end of the study than

> did subjects whose households never smoked.(ABSTRACT TRUNCATED AT 250

> WORDS)

>

> PMID: 8239163 [PubMed - indexed for MEDLINE]

>

>

>

>

> -------------------------------------------

> The opinions and information exchanged on this list should IN NO WAY

> be construed as medical advice.

>

> PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR

TREATMENTS.

>

> ------------------------------------

>

>

>