Guest guest Posted June 13, 2003 Report Share Posted June 13, 2003 THis is interesting I developed Cushing Syndrome several years ago and gained 65 pounds...they were never able to figure out what caused it as my hormones went back to normal by the time the 24hr cortisone levels were checked.... Journal of Cystic Fibrosis Volume 2, Issue 2 , June 2003, Pages 72-75 Copyright 2003 European Cystic Fibrosis Society. Published by Elsevier Science B. V. Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450 Elke De Wachtera, Anne Malfroot, , a, Iris De Schuttera, Vanbesienb and Jean De Schepperb a Department of Paediatrics, Paediatric Respiratory Medicine and Cystic Fibrosis Clinic, Academisch Ziekenhuis-Vrije Universiteit Brussel (AZ-VUB), Laarbeeklaan 101, B-1090, Brussels, Belgium b Paediatric Endocrinology Clinic, Academisch Ziekenhuis-Vrije Universiteit Brussel (VUB), Brussels, Belgium Two CF patients developed Cushing's syndrome during administration of inhaled budesonide (400 g/d) with oral itraconazole in one and with clarithromycin in the other patient. Clinical features appeared respectively after 2 and 6 weeks of drug co-administration, with prolonged adrenal suppression, and a slow recovery after ceasing the drugs. Inhibitors of the cytochrome P450 interfere with the metabolism of corticosteroids. Combination of these drugs even with moderate doses of budesonide should be closely monitored. Author Keywords: CYP3A4; Adrenal suppression; Drug interaction Becki YOUR FAVORITE LilGooberGirl YOUNGLUNG EMAIL SUPPORT LIST www.topica.com/lists/younglung Pediatric Interstitial Lung Disease Society http://groups.yahoo.com/group/InterstitialLung_Kids/ Quote Link to comment Share on other sites More sharing options...
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