copied by n Rojas

[Guest guest]

June 26, 2003 — Intranasal furosemide is as effective as mometasone for

chronic hyperplastic sinusitis with nasal polyps (CHS-NP), according to the

results

of a randomized, prospective, controlled trial published in the June issue of

the Archives of Otolaryngology-Head and Neck Surgery.

" The best therapeutic approach to relapse of nasal polyposis is to interfere

with the early phase of nasal polyp development. A key element in this context

is the edematous infiltrate, " write Desiderio Passàli, MD, PhD, from the

University of Siena Medical School in Italy, and colleagues. " The topical use of

furosemide, a loop diuretic and inhibitor of the potassium and sodium chloride

cotransporter channels, at the basolateral surface of the respiratory

epithelial cell may result in a decrease in sodium absorption and an ultimate

decrease

in water absorption. "

Of 170 patients with bilateral obstructive or minimally obstructive CHS-NP

treated surgically, 97 were randomized to treatment beginning one month after

surgery with intranasal furosemide, 40 to no treatment, and 33 to mometasone

furoate, a corticosteroid. Follow-up took place every six months for 1 to 9

years.

Relapses of nasal polyposis occurred in 17 (17.5%) of 97 patients receiving

furosemide, in 12 (30.0%) of 40 patients on no treatment, and in 8 (24.2%) of

33 patients receiving mometasone. Relapses in patients treated with furosemide

or mometasone were more likely to be early stage, but patients on no treatment

were more likely to have more severe grades of CHS-NP (P < .005).

" Our long-term follow-up study supports the use of furosemide as a valid

therapeutic approach to the prevention of CHS-NP and as an alternative to the

use

of topical corticosteroids, which have some clinical adverse effects on the

nasal mucosa, " the authors write.

The authors report no relevant financial interest in this article.

[Guest guest]

In a message dated 7/29/2003 3:12:36 PM Central Daylight Time,

Mcesana@... writes:

> furosemide

so is this used in a nebulizer? Or are they having them take it orally? Deb A

[Guest guest]

n, was this study done on adults or children. Wouldn't it make a

difference? Some of those words were a little big for me LOL....

Rosemary in NY with 3 children (13, 10.6 and 6.6)

with CF. I have a dog named TOBI and have

coined the phrase " BREATHE DAMMIT "