Guest guest Posted August 26, 2003 Report Share Posted August 26, 2003 Pretty funny post, bud sadly likely to be the case! Alas! n Rojas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 26, 2003 Report Share Posted August 26, 2003 , Thanks for both these asthma articles. I'm going to go find the study mentioned in your first post. I want to see what they tested and found in people's blood. I have a hunch, already, based on astham and magnesium deficiency studies. Oops, there's that magnesium word again... And the maddening issue about this article is that these researchers are either apparently blind in one eye or thinking with only half their brains. They postulate that beta argonists such as albuterol, ventolin, and salbutamol stop becoming effective because the body becomes desensitized. Oh, jeez. What about the fact these meds deplete magnesium, which increases bronchoconstriction and incidences of astham? And the researchers say women have more severe asthma then men. Oh, duh! Women as a whole are more magnesium deficient than men! Kim --- " Palazola " <annapalazola@y...> wrote: > > > Drugs 'make asthma worse' > > > Asthmatics can become oversensitive to triggers > Using too much medication may actually make asthma worse, researchers > say. > Scientists believe they have discovered why common asthma treatments > such as albuterol, ventolin and salbutamol can stop being effective. > > All three are beta-agonist drugs, taken via an inhaler or nebuliser > or as tablets, liquid or by injection, which relax the airways. > > In the short-term, the drugs have an immediate effect. > > A significant loss of effectiveness of treatment has not been > demonstrated > > Professor Martyn Partridge, National Asthma Campaign > But some studies have shown long-term daily use can make the drugs > less effective. > > > It had been thought that this was because the body became > desensitised to the effect of the drug. > > But the US researchers say the body actually becomes over-sensitive > to asthma triggers if the drugs are used long-term. > > They say they have discovered why this can happen, and that their > findings study could lead to a new way of treating asthma. > > Sensitivity > > Beta-antagonists bind to a receptor called beta2-adrenergic receptor > (beta2AR) in lung tissue, which detects the drugs and makes them act. > > Researchers from the University of Cincinnati, who looked at mice > genetically engineered to either have low or high levels of beta 2AR > activity. > > They found long-term activation of beta 2AR also triggers high levels > of an enzyme called phospholipase C- beta (PLC-beta) in smooth muscle > in the lungs. > > This process makes the airways highly sensitive to asthma triggers. > > The research is published in the Journal of Clinical Investigation. > > In an editorial in the journal, Shore and Drazen > from the Harvard School of Public Health and Brigham and Women's > Hospital in Boston, Massachusetts, write it is possible that this > is " just the tip of the iceberg " . > > They add that understanding the effects of beta2AR activation could > lead to the development of new medications. > > Professor Martyn Partridge, chief medical advisor to the National > Asthma Campaign, told BBC News Online: " This is an area of > considerable scientific interest, but at a clinical level. > > " This should cause no concern to those with asthma as a significant > loss of effectiveness of treatment has not been demonstrated in these > studies. " > > He added: " What is important is to move the emphasis away from the > need for short-acting relief medication on a regular basis and to > look at controlling the condition through the use of preventative > treatment. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 26, 2003 Report Share Posted August 26, 2003 Hi Kim, I was home all day, not by choice, we built a new addition to our house and I had to wait for the carpet people, I was " stuck " at home. I was supposed to list two houses instead I had to wait for the carpet installers. I had plenty time to navigate the net and find all kind of interesting things, including these two articles. I am glad they were of use, you got me sold on Mg and Lema oil so I thank you for that, keep on preaching sister the more you write the more I know. mom of a 10 wcf, Venanzio 7 nocf, Pepe 3 nocf > > > > > > Drugs 'make asthma worse' > > > > > > Asthmatics can become oversensitive to triggers > > Using too much medication may actually make asthma worse, > researchers > > say. > > Scientists believe they have discovered why common asthma treatments > > such as albuterol, ventolin and salbutamol can stop being effective. > > > > All three are beta-agonist drugs, taken via an inhaler or nebuliser > > or as tablets, liquid or by injection, which relax the airways. > > > > In the short-term, the drugs have an immediate effect. > > > > A significant loss of effectiveness of treatment has not been > > demonstrated > > > > Professor Martyn Partridge, National Asthma Campaign > > But some studies have shown long-term daily use can make the drugs > > less effective. > > > > > > It had been thought that this was because the body became > > desensitised to the effect of the drug. > > > > But the US researchers say the body actually becomes over- sensitive > > to asthma triggers if the drugs are used long-term. > > > > They say they have discovered why this can happen, and that their > > findings study could lead to a new way of treating asthma. > > > > Sensitivity > > > > Beta-antagonists bind to a receptor called beta2-adrenergic receptor > > (beta2AR) in lung tissue, which detects the drugs and makes them > act. > > > > Researchers from the University of Cincinnati, who looked at mice > > genetically engineered to either have low or high levels of beta 2AR > > activity. > > > > They found long-term activation of beta 2AR also triggers high > levels > > of an enzyme called phospholipase C- beta (PLC-beta) in smooth > muscle > > in the lungs. > > > > This process makes the airways highly sensitive to asthma triggers. > > > > The research is published in the Journal of Clinical Investigation. > > > > In an editorial in the journal, Shore and Drazen > > from the Harvard School of Public Health and Brigham and Women's > > Hospital in Boston, Massachusetts, write it is possible that this > > is " just the tip of the iceberg " . > > > > They add that understanding the effects of beta2AR activation could > > lead to the development of new medications. > > > > Professor Martyn Partridge, chief medical advisor to the National > > Asthma Campaign, told BBC News Online: " This is an area of > > considerable scientific interest, but at a clinical level. > > > > " This should cause no concern to those with asthma as a significant > > loss of effectiveness of treatment has not been demonstrated in > these > > studies. " > > > > He added: " What is important is to move the emphasis away from the > > need for short-acting relief medication on a regular basis and to > > look at controlling the condition through the use of preventative > > treatment. " Quote Link to comment Share on other sites More sharing options...
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