Re: Allergies, Leaky Gut and Autism and SCD

[Guest guest]

One of the most important research papers concerning autism and foods

is the Jyonouchi article. The Jyonouchi article indicates that the

intolerance to cow dairy and other foods is caused by endotoxin, a

product of the gut bacteria. So if we remove the gut bacteria with

SCD,then we should see an improvement in tolerating these foods.

Please read the information below. It is found in pecanbread.com

Mimi

Elaine Gottschall's Comments on Jyonouchi's Paper

The abstract of Jyonouchi's paper says Children with autism spectrum

disorder (ASD) frequently reveal various gastrointestinal (GI)

symptoms that may resolve with an elimination diet along with apparent

improvement of some of the behavorial symptoms. Evidence suggests that

ASD may be accompanied by aberrant (inflammatory) innate immune

responses. THIS MAY PREDISPOSE ASD CHILDREN TO SENSITIVIES TO COMMON

DIETARY PROTEINS LEADING TO GI INFLAMMATION AND AGGRAVATION OF SOME

BEHAVIORAL SYMPTOMS.

The authors demonstrate conclusively that there is an abnormal immune

response to cow's milk protein and wheat protein (gliadin) and soy in

ASD. What is interesting is that the diet model is NOT THE SAME AS THE

OPIOID MODEL BUT IS BASED ON A VARIABLE IMMUNE RESPONSE IN WHICH NOT

EVERY CHILD WILL SHOW SENSITIVITY TO EVERY FOOD.

But the punch line is: The authors suggest that the root cause of the

food protein sensitivity may be an underlying sensitivity to endotoxin

or lipopolysaccharides (LPS) which comes from the surfaces of gram

negative bacteria in the gut.

This summarized means that this response to the bacterial endotoxin

(LPS) PREDISPOSE THESE CHILDREN TO SENSITIZATION TO DIETARY PROTEINS.

This is consistent with a model of abnormal gut flora development that

promotes immune response to gut bacteria. This means that ASD kids may

develop a kind of autoimmunie response to their own gut flora.

Neuropsychobiology. 2002;46(2):76-84

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2378124 & dopt=Abstract

Innate immunity associated with inflammatory responses and cytokine

production against common dietary proteins in patients with autism

spectrum disorder.

Jyonouchi H, Sun S, Itokazu N.

Department of Pediatrics, University of Minnesota, Minneapolis, Minn, USA.

OBJECTIVES: Children with autism spectrum disorder (ASD) frequently

reveal various gastrointestinal (GI) symptoms that may resolve with an

elimination diet along with apparent improvement of some of the

behavioral symptoms. Evidence suggests that ASD may be accompanied by

aberrant (inflammatory) innate immune responses. This may predispose

ASD children to sensitization to common dietary proteins (DP), leading

to GI inflammation and aggravation of some behavioral symptoms.

METHODS: We measured IFN-gamma, IL-5, and TNF-alpha production against

representative DPs [gliadin, cow's milk protein (CMP), and soy] by

peripheral blood mononuclear cells (PBMCs) from ASD and control

children [those with DP intolerance (DPI), ASD siblings, and healthy

unrelated children]. We evaluated the results in association with

proinflammatory and counter-regulatory cytokine production with

endotoxin (LPS), a microbial product of intestinal flora and a

surrogate stimulant for innate immune responses. RESULTS: ASD PBMCs

produced elevated IFN-gamma and TNF-alpha, but not IL-5 with common

DPs at high frequency as observed in DPI PBMCs.

ASD PBMCs revealed increased proinflammatory cytokine responses with

LPS at high frequency with positive correlation between

proinflammatory cytokine production with LPS and IFN-gamma and

TNF-alpha production against DPs. Such correlation was less evident in

DPI PBMCs. CONCLUSION: Immune reactivity to DPs may be associated with

apparent DPI and GI inflammation in ASD children that may be partly

associated with aberrant innate immune response against endotoxin, a

product of the gut bacteria. Copyright 2002 S. Karger AG, Basel

PMID: 12378124 [PubMed - indexed for MEDLINE]

> For those who want to know. I urge you to go to these links for

> clarification of what I have been trying to say about allergies, leaky gut

> and autism and how SCD helps those with these problems.

>

> Antoinette (celiac) mother to Kiki-2 (celiac/asd/pdd) SCD 2/06

>

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http://www.breakingtheviciouscycle.info/knowledge_base/kb/casein_sensitivity.htm\

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http://www.breakingtheviciouscycle.info/knowledge_base/kb/allergies.htm<http://w\

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http://www.breakingtheviciouscycle.info/autism/autism_and_gi_problems.htm<http:/\

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http://www.breakingtheviciouscycle.info/autism/about_autism.htm<http://www.break\

ingtheviciouscycle.info/autism/about_autism.htm>

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http://www.breakingtheviciouscycle.info/images/AutismBinder.pdf<http://www.break\

ingtheviciouscycle.info/images/AutismBinder.pdf>

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http://www.breakingtheviciouscycle.info/testimonies/pam_ferro.htm<http://www.bre\

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