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Hi ,

I am not sure but you can ask the expert Mom on Glutathione Hudson or Dr

Bishop who is the Doc she is hooked up with at the Utah Valley Institute of

Cystic Fibrosis through their web site.

http://members.tripod.com/uvicf/index.htm

glutathione question

HI all

I want to start Liam on oral glutathione, now is this the same as glutamine

tablets??

Thanks

mum to Liam 10 months and Lily in heaven wcf

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Glutamine is different from glutathione.

~

> HI all

> I want to start Liam on oral glutathione, now is this the same as

glutamine tablets??

>

> Thanks

> mum to Liam 10 months and Lily in heaven wcf

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Hi ,

No, glutathione and glutamine are not the same things. Glutathione is

an antioxidant produced in the body, glutamine is an amino acid.

Amino acids are the building blocks of proteins and enzymes; they are

needed for growth, repair and maintenance of the body. There are 20

amino acids -- nine are called " essential " amino acids because the

body cannot make them, you must get them from your diet. The other 11

are called " nonessential " because the body manufacturers despite diet.

However, *all* 20 are very essential to health!

Glutamine is the most abundant amino acid; it's a nonessential (the

body makes it) amino acid with many functions, one of which is

anti-inflammatory. Also, in the body glutamine combines with n-acetyl

cysteine (NAC) to help synthesize glutathione (GSH). NAC has

antioxidant activity, and it helps thin mucus.

NAC also has some detox properties. Hospitals use it to detox after

acetominophen overdose and to protect the liver from certain toxic

medical agents, such as dye used in angiograms. People who inhale NAC

(also called Mucomyst) often complain of it's rotten egg smell, which

is due to its sulfur component.

Glutathione (GSH) is made from three other nonessential amino acids:

cysteine, glycine -- and this is the part that confuses me: I've read

the third amino acid is glutamic acid (also known as gluatamate), but

also read that it's gamma-glutamic acid. So I'm not sure if glutamate

is another name for gamma-glutamic acid or not.

Anyway, that glutamatic acid (or gamma-glutamic acid) is not to be

confused with the amino acid glutamine -- though remember, glutamine

helps synthesize GSH when combined with NAC.

GSH prevents oxidative stress (antioxidant properties) and helps trap

free radicals that damage RNA and DNA, and it helps remove toxins from

the body.

Because we often talk about sulfur and how it helps CF, it might help

you to understand that cysteine (mentioned above as a component of

GSH). Cysteine, a nonessential amino acid, is one of the few amino

acids that contain sulfur.

The body needs cysteine to produce taurine. Some call taurine an amino

acid, but others call it an amino acid compound, or amino acid-like

compound. These discrepancies don't help my understanding of all this!

Anyway, taurine has many roles but to stay on the CF topic, taurine is

found abundantly in chenodeoxychloic acid, a bile acid that emulsifies

fats in the intestine and helps digestion.

Back to cysteine -- cysteine is also necessary for the metabolism of

lipoic acid and biotin. Biotin (found abundandly in eggs) is also

called Vitamin H; it's a co-factor in the utilization of essential

fatty acids. Funny how eggs and sulfur keep popping up as I write

this...

Cysteine gets it's sulfur from the essential amino acid, methionine.

My understanding is that cysteine is " nonessential " only as long as it

has enough methinonine, and methinonine being " essential " means you

must get methionine from food. Which I guess that's why it's helpful

in CF to eat high sulfur foods or take MSM (methyl-sulfylmethionine)

to ensure you have enough methionine to be sure the body can

manufacture enough cysteine so that it can make enough of everything

else related to it.

Glycine (a nonessential amino acid also mentioned above as a component

of GSH) is necessary for the synthesis of other amino acids, bile

acids and nucleic acids.

And if the word glycine is ringing bells, for those of you taking

Solgar's magnesium glycinate -- this is magnesium chelated to glycine.

Tah dah! That's my oversimplified nutshell view on this. But someone

please jump to help if I've gotten the sequence wrong!

Kim

--- " & O'Neill " <smoneill@x> wrote:

I want to start Liam on oral glutathione, now is this the same as

glutamine tablets??

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The CFF has issued a statement on the subject glutathione. You can

find it by going to http://www.cff.org and clicking on the link, " A

Letter to CF Patients and Their Families Regarding Glutathione. "

There is mention of Hudson and her study in the letter.

~

mommy of 3, 1 with cf

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