Guest guest Posted June 18, 2003 Report Share Posted June 18, 2003 Cystic fibrosis, pregnancy, and new acquisition of Burkholderia cepacia , M.D. EM is a 37 year old white female with a history of cystic fibrosis who presented to UNC during her third pregnancy. She had done well with her first two pregnancies but during the thirty-seventh week of this pregnancy she developed a cough, productive sputum and high temperatures. She was admitted to the hospital for IV antibiotics, subsequently grew Pseudomonas aeruginosa and was sent home in improved condition to complete a two-week course of antibiotics. Unfortunately, she returned two days after discharge with return of high temperatures, increasing purulent cough, and new hemoptysis. Delivery of the child was induced, but she continued to have purulent sputum and progression of her illness. During this hospitalization, her sputum cultures grew Burkholderia cepacia for the first time. Her antibiotic regimen was changed and she subsequently improved. Her long-term course has been one of steady decline since the original diagnosis. This case, therefore, raises questions regarding the risks of pregnancy in CF, and whether pregnancy induces immune deficits that may predispose a CF patient to worsened/new infections. These issues are important to address, given the rising number of CF patients who become pregnant each year. Over the last eight years, there have been 1091 pregnancies with 551 live births reported to the CF registry (1). There have been multiple studies done to evaluate if pregnancy affects pulmonary function and/or mortality; the most recent and thorough study released in July 2000. This study concluded that pregnancy did not affect survival or the pulmonary function when compared to matched, non-pregnant CF controls. Therefore, pregnancy in and of itself may not pose a significant risk to CF patients unless they have advanced lung disease (FEV1 <50%) (2). The other question raised by the new acquisition of B. cepacia during/after pregnancy is whether host immune function declines, and therefore predisposes patients to infection during this period. Review of the literature concerning pregnancy and immune function reveals agreement that there may be down-regulation of T helper type-1 lymphocytes, which may indeed cause an increase risk for cell-mediated infections (viruses, e.g.). There is no evidence, however, that pregnancy may predispose to bacterial infections via this mechanism (3). It is doubtful, then, that pregnancy predisposed this patient to the acquisition of B. cepacia, and that acquisition may have been coincidental, given lack of evidence or nosocomial acquisition, after a thorough search. Bibilography 1 CF Registry Data 1991-1998 2 Gilljam, M. et.al, Pregnancy in Cystic Fibrosis; Chest (118): 85-91 3 " Immunology of Pregnancy " , Silver, RM. et.al, Maternal-Fetal Medicine, W.B. Saunders Company: 72-89 Quote Link to comment Share on other sites More sharing options...
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