Jump to content
RemedySpot.com

interesting

Rate this topic


Guest guest

Recommended Posts

Guest guest

<A HREF= " http://content.nejm.org/ " >HOME</A>   |   <A

HREF= " http://content.nejm.org/search.dtl " >SEARCH</A>   |   <A

HREF= " http://content.nejm.org/current.shtml " >CURRENT ISSUE</A>   |   <A

HREF= " http://content.nejm.org/contents-by-date.0.shtml " >PAST ISSUES</A>

  |   <A HREF= " http://content.nejm.org/collections/ " >COLLECTIONS</A>

  |   <A HREF= " http://content.nejm.org/help/ " >HELP</A>

 

<A HREF= " http://content.nejm.org/cgi/content/short/346/21/1616 " >Previous</A>

Volume 346:1623-1630 May 23, 2002 Number 21

<A HREF= " http://content.nejm.org/cgi/content/short/346/21/1631 " >Next</A>

Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass

Surgery

E. Cummings, M.D., S. Weigle, M.D., R. Frayo, B.S.,

A. Breen, B.S.N., Marina K. Ma, E. Patchen Dellinger, M.D., and

Q. Purnell, M.D.

 

<A HREF= " http://content.nejm.org/content/vol346/issue21/index.shtml " >Table

of Contents</A>

<A HREF= " http://content.nejm.org/cgi/content/full/346/21/1623 " >Full Text of

this article</A>

<A HREF= " http://content.nejm.org/cgi/reprint/346/21/1623 " >PDF of this

article</A>

<A

HREF= " http://content.nejm.org/cgi/ac_external_ref?link_type=pda_mms & doi=10.1056%\

2FNEJMoa012908 " >PDA version of this article</A>

<A

HREF= " http://content.nejm.org/cgi/content/short/346/21/'/cgi/content-tweek/full/\

346/21/1605-b'; " >Editor's Summary</A>

<A

HREF= " http://content.nejm.org/cgi/content/short/346/21/#related_letters " >Related

Letters to the Editor</A>

Related editorials in the Journal: <A

HREF= " http://content.nejm.org/cgi/content/short/346/21/1662 " >Flier, J. S.</A>

<A

HREF= " http://content.nejm.org/cgi/search?qbe=nejm;346/21/1623 & journalcode=nejm & m\

inscore=5000 " >Find Similar Articles in the Journal</A>

<A

HREF= " http://content.nejm.org/cgi/mailafriend?url=http://content.nejm.org/cgi/co\

ntent/short/346/21/1623 & title=Plasma+Ghrelin+Levels+after+Diet-Induced+Weight+Lo\

ss+or+Gastric+Bypass+Surgery " >Notify a friend about this article</A>

<A

HREF= " http://genmed.jwatch.org/cgi/content/full/2002/607/4?ijkey=23ct0JCC9b0F6 & k\

eytype=ref & siteid=jnlwatch " >Journal Watch (General) Summary</A>

<A

HREF= " http://content.nejm.org/cgi/folders?action=addtofolder & wherefrom=JOURNALS & \

wrapped_id=nejm;346/21/1623 " >Add to Personal Archive</A>

<A HREF= " http://content.nejm.org/cgi/citmgr?gca=nejm;346/21/1623 " >Download

to Citation Manager</A>

<A

HREF= " http://content.nejm.org/cgi/alerts/ctalert?alertType=citedby & addAlert=cite\

d_by & saveAlert=no & cited_by_criteria_resid=nejm;346/21/1623 & return_type=article & r\

eturn_url=%2Fcgi%2Fcontent%2Fshort%2F346%2F21%2F1623 " >Alert me when this article

is cited</A>

ISI Web of Science <A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=nejm%3B346%2F21%2F1623\

& link_type=ISI_RelatedRecords " >Related Articles</A> <A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=nejm%3B346%2F21%2F1623\

& link_type=ISI_Citing " >Citing Articles (37)</A>

<A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=12023994 & link_type=MED\

_NBRS " >Related Articles in Medline</A>

Articles in Medline by Author: <A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=Cummings+DE & link_type=\

AUTHORSEARCH " >Cummings, D. E.</A>

<A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=Purnell+JQ & link_type=A\

UTHORSEARCH " >Purnell, J. Q.</A>

<A

HREF= " http://content.nejm.org/cgi/external_ref?access_num=12023994 & link_type=PUB\

MED " >Medline Citation</A>

<A

HREF= " http://content.nejm.org/cgi/collection/dietnutrition " >Diet/Nutrition</A>

<A HREF= " http://content.nejm.org/cgi/collection/obesity " >Obesity</A>

<A HREF= " http://content.nejm.org/cgi/harrison/short/346/21/1623 " >Related

Chapters at on's Online</A>

ABSTRACT

Background Weight loss causes changes in appetite and energy expenditure that

promote weight regain. Ghrelin is a hormone that increases food intake in

rodents and humans. If circulating ghrelin participates in the adaptive

response to weight loss, its levels should rise with dieting. Because ghrelin

is produced primarily by the stomach, weight loss after gastric bypass

surgery may be accompanied by impaired ghrelin secretion.

Methods We determined the 24-hour plasma ghrelin profiles, body composition,

insulin levels, leptin levels, and insulin sensitivity in 13 obese subjects

before and after a six-month dietary program for weight loss. The 24-hour

ghrelin profiles were also determined in 5 subjects who had lost weight after

gastric bypass and 10 normal-weight controls; 5 of the 13 obese subjects who

participated in the dietary program were matched to the subjects in the

gastric-bypass group and served as obese controls.

Results Plasma ghrelin levels rose sharply shortly before and fell shortly

after every meal. A diet-induced weight loss of 17 percent of initial body

weight was associated with a 24 percent increase in the area under the curve

for the 24-hour ghrelin profile (P=0.006). In contrast, despite a 36 percent

weight loss after gastric bypass, the area under the curve for the ghrelin

profile in the gastric-bypass group was 77 percent lower than in

normal-weight controls (P<0.001) and 72 percent lower than in matched obese

controls (P=0.01). The normal, meal-related fluctuations and diurnal rhythm

of the ghrelin level were absent after gastric bypass.

Conclusions The increase in the plasma ghrelin level with diet-induced weight

loss is consistent with the hypothesis that ghrelin has a role in the

long-term regulation of body weight. Gastric bypass is associated with

markedly suppressed ghrelin levels, possibly contributing to the

weight-reducing effect of the procedure.

Source Information

From the Departments of Medicine (D.E.C., D.S.W., R.S.F., P.A.B., M.K.M.) and

Surgery (E.P.D.), University of Washington; the Veterans Affairs Puget Sound

Health Care System (D.E.C., R.S.F., M.K.M.); the Harborview Medical Center

(D.S.W., P.A.B.); and University Hospital (E.P.D.) — all in Seattle; and the

Department of Medicine, Oregon Health and Science University, Portland

(J.Q.P.).

Address reprint requests to Dr. Cummings at the Veterans Affairs Puget Sound

Health Care System, Seattle Div., 1660 S. Columbian Way, S-111-Endo, Seattle,

WA 98108, or at <A

HREF= " mailto:davidec@... " >davidec@...</A>.

<A HREF= " http://content.nejm.org/cgi/content/full/346/21/1623 " >Full Text of this

Article</A>

Related Letters:

Weight Loss and Plasma Ghrelin Levels

Rubino F., Gagner M., Camilleri M., Cremonini F., Geliebter A., Cummings D.

E., Purnell J. Q., Weigle D. S.

<A HREF= " http://content.nejm.org/cgi/content/full/347/17/1379 " >Full Text</A> |

<A HREF= " http://content.nejm.org/cgi/reprint/347/17/1379 " >PDF</A>  

N Engl J Med 2002; 347:1379-1381, Oct 24, 2002. Correspondence

This article has been cited by other articles:

Freda, P. U., Reyes, C. M., Conwell, I. M., Sundeen, R. E., Wardlaw, S. L.

(2003). Serum Ghrelin Levels in Acromegaly: Effects of Surgical and

Long-Acting Octreotide Therapy. J Clin Endocrinol Metab 88: 2037-2044 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/5/2037 " >

[Abstract]</A> <A

HREF= " http://jcem.endojournals.org/cgi/content/full/88/5/2037 " >[Full Text]</A>

 

Barkan, A. L., Dimaraki, E. V., Jessup, S. K., Symons, K. V., Ermolenko, M.,

Jaffe, C. A. (2003). Ghrelin Secretion in Humans Is Sexually Dimorphic,

Suppressed by Somatostatin, and Not Affected by the Ambient Growth Hormone

Levels. J Clin Endocrinol Metab 88: 2180-2184 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/5/2180 " >[Abstract]</A\

> <A HREF= " http://jcem.endojournals.org/cgi/content/full/88/5/2180 " >[Full

Text]</A>  

Polyzogopoulou, E. V., Kalfarentzos, F., Vagenakis, A. G., andrides, T.

K. (2003). Restoration of Euglycemia and Normal Acute Insulin Response to

Glucose in Obese Subjects With Type 2 Diabetes Following Bariatric Surgery.

Diabetes 52: 1098-1103 <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/abstract/52/5/1098 " >[Abst\

ract]</A> <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/full/52/5/1098 " >[Full

Text]</A>  

Nwokolo, C U, Freshwater, D A, O'Hare, P, Randeva, H S (2003). Plasma ghrelin

following cure of Helicobacter pylori. Gut 52: 637-640 <A

HREF= " http://gut.bmjjournals.com/cgi/content/abstract/52/5/637 " >[Abstract]</A>

<A HREF= " http://gut.bmjjournals.com/cgi/content/full/52/5/637 " >[Full Text]</A>

 

Duell, P. B. (2003). Bariatric Surgery for Morbid Obesity. JAMA 289:

1779-1779 <A HREF= " http://jama.ama-assn.org/cgi/content/full/289/14/1779 " >[Full

Text]</A>  

Faraj, M., Havel, P. J., Phelis, S., Blank, D., Sniderman, A. D., Cianflone,

K. (2003). Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and

Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in

Morbidly Obese Subjects. J Clin Endocrinol Metab 88: 1594-1602 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/4/1594 " >[Abstract]</A\

> <A HREF= " http://jcem.endojournals.org/cgi/content/full/88/4/1594 " >

[Full Text]</A>  

Weigle, D. S., Cummings, D. E., Newby, P. D., Breen, P. A., Frayo, R. S.,

Matthys, C. C., Callahan, H. S., Purnell, J. Q. (2003). Roles of Leptin and

Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate

Diet. J Clin Endocrinol Metab 88: 1577-1586 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/4/1577 " >[Abstract]</A\

> <A HREF= " http://jcem.endojournals.org/cgi/content/full/88/4/1577 " >[Full

Text]</A>  

Cummings, D. E., , M. H. (2003). Roles for Ghrelin in the Regulation

of Appetite and Body Weight. Arch Surg 138: 389-396 <A

HREF= " http://archsurg.ama-assn.org/cgi/content/full/138/4/389 " >[Full Text]</A>

 

Mason, E. E. (2003). Development and Future of Gastroplasties for Morbid

Obesity. Arch Surg 138: 361-366 <A

HREF= " http://archsurg.ama-assn.org/cgi/content/full/138/4/361 " >[Full Text]</A>

 

Korner, J., Aronne, L. J. (2003). The emerging science of body weight

regulation and its impact on obesity treatment. J. Clin. Invest. 111: 565-570

<A HREF= " http://www.jci.org/cgi/content/full/111/5/565 " >[Full Text]</A>  

Riis, A. L. D., Hansen, T. K., Moller, N., Weeke, J., nsen, J. O. L.

(2003). Hyperthyroidism Is Associated with Suppressed Circulating Ghrelin

Levels. J Clin Endocrinol Metab 88: 853-857 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/2/853 " >[Abstract]</A>

<A HREF= " http://jcem.endojournals.org/cgi/content/full/88/2/853 " >[Full Text]</A>

 

Gaytan, F., Barreiro, M. L., Chopin, L. K., Herington, A. C., Morales, C.,

Pinilla, L., Casanueva, F. F., Aguilar, E., Dieguez, C., Tena-Sempere, M.

(2003). Immunolocalization of Ghrelin and Its Functional Receptor, the Type

1a Growth Hormone Secretagogue Receptor, in the Cyclic Human Ovary. J Clin

Endocrinol Metab 88: 879-887 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/2/879 " >[Abstract]</A>

<A HREF= " http://jcem.endojournals.org/cgi/content/full/88/2/879 " >[Full Text]</A>

 

Schwartz, M. W., Woods, S. C., Seeley, R. J., Barsh, G. S., Baskin, D. G.,

Leibel, R. L. (2003). Is the Energy Homeostasis System Inherently Biased

Toward Weight Gain?. Diabetes 52: 232-238 <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/abstract/52/2/232 " >[Abstr\

act]</A> <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/full/52/2/232 " >[Full

Text]</A>  

Flanagan, D. E., , M. L., Monsod, T. P., Rife, F., Heptulla, R. A.,

Tamborlane, W. V., Sherwin, R. S. (2003). The influence of insulin on

circulating ghrelin. Am. J. Physiol. 284: E313-316 <A

HREF= " http://ajpendo.physiology.org/cgi/content/abstract/284/2/E313 " >[Abstract]<\

/A> <A HREF= " http://ajpendo.physiology.org/cgi/content/full/284/2/E313 " >[Full

Text]</A>  

Cummings, D. E., Schwartz, M. W. (2003). GENETICS AND PATHOPHYSIOLOGY OF

HUMAN OBESITY. Annu. Rev. Medicine 54: 453-471 <A

HREF= " http://med.annualreviews.org/cgi/content/abstract/54/1/453 " >[Abstract]</A>

<A HREF= " http://med.annualreviews.org/cgi/content/full/54/1/453 " >[Full Text]</A>

 

Hosoda, H., Kojima, M., Kangawa, K. (2002). Ghrelin and the Regulation of

Food Intake and Energy Balance. Mol. Interv. 2: 494-503 <A

HREF= " http://molinterv.aspetjournals.org/cgi/content/abstract/2/8/494 " >[Abstract\

]</A> <A

HREF= " http://molinterv.aspetjournals.org/cgi/content/full/2/8/494 " >[Full

Text]</A>  

Greenway, S. E., Greenway III, F. L., Klein, S. (2002). Effects of Obesity

Surgery on Non-Insulin-Dependent Diabetes Mellitus. Arch Surg 137: 1109-1117 <A

HREF= " http://archsurg.ama-assn.org/cgi/content/abstract/137/10/1109 " >

[Abstract]</A> <A

HREF= " http://archsurg.ama-assn.org/cgi/content/full/137/10/1109 " >[Full Text]</A>

 

Haqq, A. M., Farooqi, I. S., O'Rahilly, S., Stadler, D. D., Rosenfeld, R. G.,

Pratt, K. L., LaFranchi, S. H., Purnell, J. Q. (2003). Serum Ghrelin Levels

Are Inversely Correlated with Body Mass Index, Age, and Insulin

Concentrations in Normal Children and Are Markedly Increased in Prader-Willi

Syndrome. J Clin Endocrinol Metab 88: 174-178 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/88/1/174 " >[Abstract]</A>

<A HREF= " http://jcem.endojournals.org/cgi/content/full/88/1/174 " >[Full Text]</A>

 

Schaller, G., Schmidt, A., Pleiner, J., Woloszczuk, W., Wolzt, M., Luger, A.

(2003). Plasma Ghrelin Concentrations Are Not Regulated by Glucose or

Insulin: A Double-Blind, Placebo-Controlled Crossover Clamp Study. Diabetes

52: 16-20 <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/abstract/52/1/16 " >[Abstra\

ct]</A> <A

HREF= " http://diabetes.diabetesjournals.org/cgi/content/full/52/1/16 " >[Full

Text]</A>  

(2002). Lucina. Arch. Dis. Child. 87: 564-564 <A

HREF= " http://adc.bmjjournals.com/cgi/content/full/archdischild;87/6/564 " >[Full

Text]</A>  

Lindeman, J. H.N., Pijl, H., van Dielen, F. M.H., Lentjes, E. G.W.M., van

Leuven, C., Kooistra, T. (2002). Ghrelin and the Hyposomatotropism of

Obesity. Obes Res 10: 1161-1166 <A

HREF= " http://www.obesityresearch.org/cgi/content/abstract/10/11/1161 " >[Abstract]\

</A> <A HREF= " http://www.obesityresearch.org/cgi/content/full/10/11/1161 " >[Full

Text]</A>  

Bray, G. A. (2002). The Underlying Basis for Obesity: Relationship to Cancer.

J. Nutr. 132: 3451S-3455 <A

HREF= " http://nutrition.org/cgi/content/abstract/132/11/3451S " >[Abstract]</A> <A

HREF= " http://nutrition.org/cgi/content/full/132/11/3451S " >[Full Text]</A>  

Rubino, F., Gagner, M., Camilleri, M., Cremonini, F., Geliebter, A.,

Cummings, D. E., Purnell, J. Q., Weigle, D. S. (2002). Weight Loss and Plasma

Ghrelin Levels. N Engl J Med 347: 1379-1381 <A

HREF= " http://content.nejm.org/cgi/content/full/347/17/1379 " >[Full Text]</A>  

Tschop, M., Flora, D. B., Mayer, J. P., Heiman, M. L. (2002). Hypophysectomy

Prevents Ghrelin-Induced Adiposity and Increases Gastric Ghrelin Secretion in

Rats. Obes Res 10: 991-999 <A

HREF= " http://www.obesityresearch.org/cgi/content/abstract/10/10/991 " >[Abstract]<\

/A> <A HREF= " http://www.obesityresearch.org/cgi/content/full/10/10/991 " >[Full

Text]</A>  

Schofl, C., Horn, R., Schill, T., Schlosser, H. W., Muller, M. J., Brabant,

G. (2002). Circulating Ghrelin Levels in Patients with Polycystic Ovary

Syndrome. J Clin Endocrinol Metab 87: 4607-4610 <A

HREF= " http://jcem.endojournals.org/cgi/content/abstract/87/10/4607 " >[Abstract]</\

A> <A HREF= " http://jcem.endojournals.org/cgi/content/full/87/10/4607 " >[Full

Text]</A>  

(2002). Ghrelin Hormone Is an Important Appetite Stimulant. Journal Watch

Psychiatry 2002: 14-14 <A

HREF= " http://psych.jwatch.org/cgi/content/full/2002/724/14 " >[Full Text]</A>  

Hirsch, J. (2002). The search for new ways to treat obesity. Proc. Natl.

Acad. Sci. U. S. A. 99: 9096-9097 <A

HREF= " http://www.pnas.org/cgi/content/full/99/14/9096 " >[Full Text]</A>  

(2002). Ghrelin Hormone Is an Important Appetite Stimulant. Journal Watch

(General) 2002: 4-4 <A

HREF= " http://genmed.jwatch.org/cgi/content/full/2002/607/4 " >[Full Text]</A>  

Flier, J. S., Maratos-Flier, E. (2002). The Stomach Speaks -- Ghrelin and

Weight Regulation. N Engl J Med 346: 1662-1663 <A

HREF= " http://content.nejm.org/cgi/content/full/346/21/1662 " >[Full Text]</A>  

<A HREF= " http://content.nejm.org/ " >HOME</A>   |   <A

HREF= " http://content.nejm.org/search.dtl " >SEARCH</A>   |   <A

HREF= " http://content.nejm.org/current.shtml " >CURRENT ISSUE</A>   |   <A

HREF= " http://content.nejm.org/contents-by-date.0.shtml " >PAST ISSUES</A>

  |   <A HREF= " http://content.nejm.org/collections/ " >COLLECTIONS</A>

  |   <A HREF= " http://content.nejm.org/help/ " >HELP</A>

Comments and questions? Please <A

HREF= " http://www.nejm.org/custserv/feedback.asp " >contact us</A>.

The New England Journal of Medicine is owned, published, and <A

HREF= " http://www.nejm.org/aboutnejm/copyright.asp " >copyrighted</A> ©

2003 <A HREF= " http://www.massmed.org/ " >Massachusetts Medical Society</A>. All

rights reserved.

Link to comment
Share on other sites

Join the conversation

You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...