OT:] Seldom is LDN stand-alone treatment

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Just posting this for people who are having trouble with LDN

Dr. McCandless:

"Seldom is LDN stand-alone treatment"

It takes some people longer to respond to LDN, and they may be colonized with pathogenic yeast and bacteria that could be slowing response.These setbacks usually do not last long unless something like a yeast infection is stubborn without specific treatment.Dr. JMMORE BELOWThere is a phenomenon that happens to some people that as the immune system is shifting (usually from T2 to T1) right after starting LDN, the immune system drops and people get an infection, cold, flu, cold sore, etc. which is usually short lived. Candida tends to overgrow or a virus will flare up. These infections are usually short-lived unless something like candida and gut bacteria needs treatment. As usual, I need to emphasize that seldom is LDN a stand-alone treatment, but accompanies other strategies their body needs, especially a healthy diet.Are you a big

bread/carbohydrate/ sugar eater?Ever been tested for candida (yeast) or gut bacterial infestation?Ever been checked for hypothyroidism?Would you be willing to stop all casein (milk products) and gluten (wheat, rye, barley and oats) for a week and see if you feel better? A study done several years ago showed that 30% of us have some degree of celiac disease (intolerance/ allergy to wheat) even though the clinical symptoms may not be obvious enough to alert most people to that. When anyone in that 30% of persons stops eating wheat, they feel a lot better. The LDN may be acting like the opioid antagonist it is and causing a withdrawal reaction from taking away your fix, even if only for a few hours.Try to hang in for awhile longer, and it will probably get better. These setbacks usually do not last long unless something like a yeast infection is stubborn without specific treatment.

Dr. JMThe following is the response to a question posted to Dr. McCandless about goat milk as a substitute for cow's milk when on LDN:"There are many, many people who take LDN who are not on a dairy-free diet, and my estimate is that about 15% need to be. Undoubtedly goat milk is healthier and easier to digest than cow's milk, but if one truly is sensitive to casein, goat milk and all animal milks except camel do have casein. Since I specialize in children with autism, who in my practice are all required to be casein/gluten free, in my studies using autistic children I never had negative reactions to LDN. When it started being used outside the autism population, I discovered that about 15% of people using it who were not on a restricted diet had hyperactivity and a negative response to LDN. I suggested they go to a low dose and work up slowly, and if that did not help, then to get off foods with the large

peptides (casein, gluten & soy) that can go to the brain and act as gluteo or caseo corticoids. With those people, LDN cuts off their "fix" (these foods are actually addictions to some people) for a long enough time that they experience negative reactions, just as drug addicts do when they are given full-dose naltrexone. Very often removal of those foods made LDN as it is with most people; no adverse reactions. Again, not 100%, which we do not understand, but almost. One exception was a child who had many severe IgE allergies - nothing eventually helped her tolerate LDN and she had to stop. My suggestion to you would be to try it with goat's milk and see if you are one of the ones who cannot tolerate it; if so, then you have to decide whether milk is that important to you. You are free to give this information to anyone who is interested." Dr. JM Dr JM responded on the LDN-Autism yahoo forum recently regarding anxiety as a

side-effect of LDN. She said that about 30% of the population has celiac disease to some degree, and that celiac is not an all or nothing thing. Therefore, she postulates that, like with autistic kids, there is something going on in the gut with many of us. This would be an allergic response to gluten (in wheat and, I think, rye barley, oats) and possibly casein (milk protein) in the gut and an incomplete digestion of these proteins. The result is a release of semi-digested food polypeptides into the blood and brain, where they don't belong, and which act as opiates--they stimulate the autistic kids to act out or to space out! The autistic kids, and the rest of us who have some degree of allergy to gluten and/or casein, are "high" on these incompletely digested molecules. When LDN comes along in the blood stream and blocks the opiate effect, we get anxious.So Dr JM absolutely recommends addressing diet first with

autistic kids, but also with others who have problems acclimating to LDN. MORE BELOWQ: Dr. JM or anyone- Does LDN cause candida?A: LDN has been noted to aggravate yeast infections and other latent pathogens, viruses, etc. as the immune system is making early adjustments. It is good to have natural yeast remedies on board when LDN is started (grapefruit seed extract, Candex, lauricidin, hi-potency probiotics, etc) to help offset this possibility. (And of course a good dietary regime that does not encourage gut inflammation which is usually the predecessor to pathogen invasion).Dr. Jaquelyn McCandlessposted by MORE BELOWThe only way to know for sure if you have candida yeast overgrowth is to get a urinary dysbiosis test (measures by-products of yeast in the urine) - stool tests can often miss yeast, but the urine will show it. This is part of the Organic Acid

Test (OAT) and is done by Metametrix, GreatPlains, and Genova Labs - it must be ordered by a physician. The entire OAT (metametrix calls it Organix) tells you what vitamins you are missing and is a very good gauge of your overall metabolic process, including toxicities and deficiencies. The dysbiosis part only measure the by-products of yeast and bacteria, and does not cost as much as the full test. This is one of the routine tests I get on all children with autism, as they have many metabolic disorders and most have yeast and bacteria and need tobe treated for this to help them improve their health.

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