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Ghrelin (sp?)

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By any chance, did anyone see 60 Minutes last night? I know this has

been in the news before, but they had a story on the tests they are

running on the hormone Ghrelin.

They showed a sampling of typical test patients...first a man who had

gastric bypass, and pre-surgery, his Ghrelin levels were through the

roof, after surgery, they were non-existant. Then, they showed a

woman who weighed about 500 pounds, and went on a conventional diet.

She lost about 5%-10% of her weight, and then Ghrelin levels

skyrocketed, causing insatiable hunger, and then a thin woman who had

almost no ghrelin. They have been studying mice who ate normally,

and when injected with Grehlin, can't stop eating.

The doctor said that normal MO or obese dieters can not, typically,

lose more than 5%-10% of their excess weight before their Ghrelin

levels rise, making it virtually impossible to lose more without drug

intervention, which matches the commonly known fact (by us, anyway),

that 95% of people can not generally lose significant amounts of

weight and keep it off. All the drug companies are scrambling to

invent the magic pill to fight Ghrelin, but they think it would take

at least another 10 years before they come up with something.

They have discovered the antithesis of Ghrelin, something called PPY

(I think), but there are possible side effects, such as memory loss,

soooo....no magic bullet yet.

in NJ

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