Re: Sleep ?? about gluten..

[Guest guest]

Sue,

If you think his problem is that he is not " entrained " or coordinated with

the light/dark cycle, methylcobalamin, a form of B12 sold in a sublingual

lozenge might help, if you think you can get him to keep it under his

tongue until it melts. That might be hard for an 18 month old, so maybe you

could dissolve it and put some of the solution under his tongue. People

who get B12 deficient usually get there because they are not making

adequate intrinsic factor in the gut, and no matter how much B12 you

swallowed, you'd still have trouble absorbing it. The sublingual goes

straight into the blood stream, just like nitroglycerine tablets.

I'll put some articles below on methylcobalamin.

Also, a friend of mine has an autistic teenaged son whose sleep cycle has

been disturbed, and he started taking taurine a couple of days ago, and

slept during the hours of 10pm-2 am for the first time in two years, his

mother said, and that was not what either of us was expecting!

My father who had Alzheimers disease was on the g/f c/f diet as long as the

place where he lived would cooperate. After about two years, they decided

not to accomodate any special diets, and my father started eating gluten

and getting up in the middle of the night and wandering. In the daytime he

just sat like a zombie in a chair, but about nightfall, he would start in

on a chorus of " Let's go! Let's go. " (Yes, those with AD

perseverate!) When we got him back on the diet, about three days later, it

was as if the fog had cleared, and he sat up from the chair where he had

been vegging, and started saying " There's Sandy. There's . There's

my kitchen. Look, there's my bedroom, etc. " It was an amazing thing to

witness, and he was soon back to talking to us more normally. But I think

the " opiate " part is more the wandering, and the sleep cycle issue is a

little different, but may be mediated through a different aspect of

gluten/casein restriction.

Brain Res 1998 Jun 8;795(1-2):98-104

Methylcobalamin amplifies melatonin-induced circadian phase shifts by

facilitation of melatonin synthesis in the rat pineal gland.

Ikeda M, Asai M, Moriya T, Sagara M, Inoue S, Shibata S.

Advanced Research Center for Human Sciences, Waseda University, Saitama, Japan.

msikeda@...

Effects of methylcobalamin (methyl-B12), a putative drug for treating human

circadian rhythm disorders, on the melatonin-induced circadian phase shifts

were

examined in the rat. An intraperitoneal injection of 1-100 microg/kg melatonin

2-h before the activity onset time (CT 10) induced phase advances of

free-running activity rhythms in a dose-dependent manner (ED50=1.3 microg/kg).

Injection of methyl-B12 (500 microg/kg) prior to melatonin (1 microg/kg)

injection induced larger phase advances than saline preinjected controls, while

the injection of methyl-B12 in combination with saline did not induce a phase

advance. These results indicate amplification of melatonin-induced phase

advances by methyl-B12. Pinealectomy abolished the phase alternating effect of

methyl-B12, suggesting a site of action within the pineal gland. In fact,

methyl-B12 significantly increased the content of melatonin in the pineal

collected 2-h after activity onset (CT 14). In contrast, no difference in

melatonin content was found at CT 10, indicating that the effect of methyl-B12

may be gated after the activity onset time when endogenous melatonin synthesis

is known to increase. These results suggest that methyl-B12 amplifies

melatonin-induced phase advances via an increase in melatonin synthesis during

the early subjective night at a point downstream from the clock regulation.

Copyright 1998 Elsevier Science B.V. All rights reserved.

PMID: 9622603 [PubMed - indexed for MEDLINE]

Chronobiol Int 1997 Nov;14(6):549-60

Transient fluctuation of serum melatonin rhythm is suppressed centrally by

vitamin B12.

Nakamura T, Uchida K, Moriguchi Y, Okamoto N, Morita Y.

Graduate School of Electronic Science and Technology, Shizuoka University,

Hamamatsu, Japan. nakamura@...

Vitamin B12 has been reported to improve sleep-wake rhythm disorders. Although

the mechanism is still unclear, a change in the sensitivity of the circadian

clock system to photic input is thought to be a possible mechanism of the

effect. In this study, the effect of the vitamin B12 on the circadian aspect of

the electroretinogram (ERG) and serum melatonin level was analyzed in rats.

Vitamin B12, alpha-(5,6-dimethylbenzimidazolyl)-co-methyl-cobamide was daily

administrated subcutaneously for 8 weeks to adult male Wister rats in the

experimental group, and saline was given to the control group. The ERGs were

recorded under dark adaptation during the night and day, and under light

adaptation (0.1 lux) during the night. Blood was drawn before and after ERG

recording. The amplitudes of the a-wave, b-wave, and trough-to-peak of both

waves and latencies of ERG were analyzed following various exposures to stimuli

of light intensity. These parameters in the group treated with vitamin B12

showed similar characteristics to the control group, and no significant

difference was observed between the two groups. The melatonin levels of both

groups before the measurement of ERG were similar under each measurement

condition. The elevated serum melatonin concentration in the control group

under

dark adaptation at night was suppressed after the series of 10-msec light

stimuli used for measurement of ERG. However, this suppressing effect of light

pulses on melatonin level was significantly inhibited in the group treated with

vitamin B12. Under light adaptation during the night and under dark adaptation

during the day, melatonin levels after the measurement of ERG were not

different

between the groups. From these results, it is suggested that vitamin B12 if

effective in suppressing melatonin rhythm disturbances introduced by transient

light stimulation, and it affects the site more central than the retinal level.

PMID: 9360022 [PubMed - indexed for MEDLINE]

Neuropsychopharmacology 1996 Nov;15(5):456-64

Effects of vitamin B12 on performance and circadian rhythm in normal subjects.

Mayer G, Kroger M, Meier-Ewert K.

Sleep Disorder Unit, Hephata Klinik, Schwatmstadt-Treysa, Germany.

This preliminary study investigates effects of methyl- and cyanocobalamin on

circadian rhythms, well-being, alertness, and concentration in healthy

subjects.

Six women (mean age 35 years) and 14 men (mean age 37 years) were randomly

assigned to treatment for 14 days with 3 mg cyano-(CB12) or methylcobalamin

(MB12) after 9 days of pre-treatment observation. Levels in the CB12 group

increased rapidly in the first, then slowly in the second treatment week,

whereas increase in the MB12 group was linear. Urinary aMT6s excretion was

reduced by both forms of vitamin B12 over 24 hours with a significant decrease

between 0700-1100 hours, whereas urinary excretion of potassium was

significantly increased between 0700-1100 hours. Activity from 2300-0700 hours

increased significantly under both forms of vitamin B12. Sleep time was

significantly reduced under MB12 intake. In this group the change in the visual

analogue scales items " sleep quality, " " concentration, " and " feeling refreshed "

between pretreatment and the first week of treatment showed significant

correlations with vitamin B12 plasma levels. Cortisol excretion and temperature

were not affected by either medication. We conclude that vitamin B12 exerts a

direct influence on melatonin. Only MB12 has a positive psychotropic alerting

effect with a distribution of the sleep-wake cycle toward sleep reduction.

Publication Types:

At 8/19/2001 -040003:40 PM, you wrote:

>Can gluten/casein disturb sleep patterns?? I am wondering cause my 16 month

>son has a gluten allergy (and possible a casein allergy too) and has had

>sleeping problems since we started him on solid foods when he was 3 months

>old..and I am wondering if I reduce/kill his gluten intake if he will sleep

>better? I am introducing gluten free foods as suggested by the GFCF

>Diet..with no gluten in one meal and all snacks. But I have only done it for

>3 days today..Any ideas or suggestions would be much appreciated. Thanks and

>take care,

>Sue..

>

>

>

[Guest guest]

I don't know why and don't care at this point, but the very first

night on gfcf diet(we went cold turkey)Jane slept through the night

for almost the first time. She continues to sleep well unless there

has been an infraction. I am still learning.

Janelle

Mommy to Jane 2 1/2 PDD-NOS

13 mos NT

[Guest guest]

> Can gluten/casein disturb sleep patterns??

Casein is a high phenol, along with many fruits and a few other

foods, and some AS kids have difficulty processing high phenols, which

can lead to sleep problems. Here is my phenol information. I hope it

helps you.

http://home.pacbell.net/cscomp/phenol.htm