Peptizyde and HN-Zyme Study/ Is Autism's Answer in the Gut?

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EXPERIMENTAL MEDICINE

> * Peptizyde and HN-Zyme Prime 4-Month Summary from the

> Enzymes and Autism Board

> * Is Autism's Answer in the Gut?

>

>

> Peptizyde and HN-Zyme Prime 4-Month Summary from the Enzymes and Autism

> Board

>

> [This paper is from DeFelice, autism researcher and

co-moderator

> of the enzymesandautism board. It has not been peer reviewed published.

It

> is intended for purposes of study and not as medical advice.]

>

> I am sending this to you for your information. This is a copy of the

4

> month summary report on the performance of Peptizyde and Zyme Prime and

how

> enzymes have been doing for the parents on the board. Hopefully you will

> find it useful. It is intended to provide some guidelines for parents in

> deciding if this is a worthwhile option for their own families. So many of

> these treatments are a shot in the dark for each individual. More products

> from different manufacturers will be announced this fall and hopefully

this

> will set a precedence for evaluating them.

>

> About the author

> DeFelice and her two wonderful boys, 7 and 9, deal with

sensory

> integration disorder and have recently recovered from PDD. They have used

> Peptizyde and Zyme Prime regularly since April, 2001. This recovery was a

> direct result of using these enzymes in conjunction with other therapies.

> They have tried several other enzyme products, the GFCF diet, the Feingold

> diet, numerous supplements, some therapies and meds. She has been a

> co-moderator of the enzymesandautism board since its establishment, is the

> current listowner, has a Masters in Science, and works with computers,

> education and biotech. Permission is granted to reproduce and distribute

> this document as needed, as long as parts are not taken and used out of

> context, and the original contact information is included.

>

>

> Peptizyde and HN-Zyme Prime 4-Month Summary from the Enzymes and Autism

> Board

>

> L. DeFelice

> kjorn@...

> August, 2001

>

> Executive Summary

>

> The overwhelming majority of respondents saw noticeable improvements

> with Peptizyde and HN-Zyme Prime. Of 151 total respondents (100%) using

> these products for at least 3 weeks, 131 (87%) reported positive results,

12

> (8%) reported negative results, and 8 (5%) reported inconclusive results.

> Significant improvements were seen in eye contact, language, humor,

> foods tolerated, foods accepted, sleep, weight gain or loss, digestion,

> stools/bowels, overall appearance, transitioning, socialization,

awareness,

> problem solving, short-term memory, flexibility in routine, range of

> interests, sound and light tolerance, sensory integration, spontaneous

> affection, and energy level among others.

> Significant decreases were seen in aggression, hyperness, anxiety,

> self-stimming, self-injurious behavior, pain, and headaches among others.

> Most positive results were apparent within the first 3 weeks. Most

> people say any side effects or adjustment effects which start with enzyme

> use stop within 3 weeks.

> The majority of respondents (about 85%) were either 100% GFCF or

> partial GFCF with enzymes. More gluten/casein foods were added as people

> stayed with Peptizyde over time. More foods were added in general with

both

> products over time.

> Parents saw significant improvements whether they are on or not on a

> restrictive diet.

> Most people return to eating most foods, although not all people can

> eat all foods. Some guidelines are noted in this summary in Part 2.

> Most people see side reactions associated with an adjustment period

> from 1-3 weeks.

> Timing is key to getting consistently positive results.

> Many people see the Happy Child Effect, which refers to the general,

> overall positive disposition of the child once they start taking Peptizyde

> and Zyme Prime regularly. The child becomes noticeably more pleasant, easy

> going, cooperative, and helpful.

> People having difficulties or concerns when starting enzymes were

far

> more likely to achieve positive results when they posted their concerns on

> the enzymesandautism board for assistance rather than attempt to discern

the

> problem themselves. This is attributed to getting more education and

> information on using enzymes which helped them make any needed

adjustments.

> Some people were able to significantly reduce their costs on food

and

> supplements by using Peptizyde and Zyme Prime. This correlated to length

of

> time on enzymes and to what extent they remained on a restrictive diet.

> Most parents found using enzymes was far more convenient and

flexible

> than a restrictive diet. This greatly reduced stress and increased

happiness

> for the entire family, improving their quality of life.

> A few people have seen no results either way; however, a few people

> have improved to the extent they no longer fit the criteria for their

> previous diagnosis.

> Enzymes have been used for years to safely assist in food

> intolerances/allergies, leaky gut, yeast and immune system support among

> others. Some people report seeing these additional benefits as well.

> Most respondents posted that Peptizyde and Zyme Prime were an

> important part of their child's improvement but not to the extent that

other

> therapies or medications were no longer needed. Each family re-evaluated

> their treatment plan as needed. Most say that adding these enzymes were

> definitely beneficial and made most other therapies more productive. They

> say the addition of enzymes allow them to streamline their overall plan to

a

> more efficient, easier, convenient, cheaper, effective and simpler

> treatment.

>

> The summary report is present in two parts. After a description of how the

> information was gathered, Part 1 contains the results, and Part 2 contains

> additional information such as guidelines for who is likely to see

benefits,

> how to get best results and possible side effects.

>

> Peptizyde and HN-Zyme Prime 4-Month Summary from the Enzymes and Autism

> Board

>

> L. DeFelice

> kjorn@...

> August, 2001

>

>

> The enzymesandautism message board was created May 13, 2001 after the

> release of Peptizyde and HN-Zyme Prime digestive enzymes. It is open

> membership and located at http://groups.yahoo.com/group/enzymesandautism.

It

> is an independent forum for families interested in the use of digestive

> enzymes to assist with nutritional issues related to autistic spectrum and

> related conditions. Digestive enzymes are an unregulated dietary

supplement

> classified as a food by the FDA, and no medical benefits are officially

> endorsed by the manufacturers. All information in this document reflects

the

> opinions and experiences of the board participants and does not reflect

the

> position of any enzyme manufacturer, formulator, or distributor. The

author

> has no financial interests with Houston Nutraceuticals or any other enzyme

> manufacturer or distributor.

>

> This report summarizes the learning and experiences of the board members

who

> posted voluntarily. The information presented concerns and is relevant

only

> to the products Peptizyde and HN-Zyme Prime (Zyme Prime) by Houston

> Nutraceuticals. It may or may not apply to other enzyme products in

general.

> This summary is to be used as a guide to help parents make better

decisions

> in the treatment of their families. Further information on these products

> can be found at the web site www.houstonni.com, or by contacting Dr. Devin

> Houston directly through this site. This summary report was conceived,

> developed and written independently of Houston Nutraceuticals. Questions

and

> comments on this summary can be directed to the author at the address

above

> or posted on the enzymesandautism message board. Thank you. Kd.

>

> Precedence for Enzymes and Autism (and related conditions)

> The search for a digestive enzyme product that could be used to

break

> down the intermediate peptides produced by gluten, casein, and now

possibly

> soy proteins has been under way since these peptides were identified as

> possible causes of some of the undesirable " autistic " behaviors. Peptizyde

> is the next step in that progression. Already in 4 months time, parents

are

> seeing highly effective results.

> http://osiris.sunderland.ac.uk/autism/durham95.html

> http://www.serenaid.com/background.html

> http://www.serenaid.com/pilotstudy.html

>

> Respondent Information

> At the time of this writing (late August 2001), there are 681

members

> of the message board 14 weeks after being established. This report is

based

> on those posts. Of course not every member has posted, and not everyone

has

> posted on the same topics. Periodically, over the course of the past few

> months, members were repeatedly encouraged to post on any results -

> positive, negative, and none. People who left the group were asked if they

> had a particular reason for leaving. The overwhelming majority said there

> were too many posts (the board was too active for them) and not due to

> specific enzyme results. Many emails were sent asking members who posted

at

> some time to comment on any type of results, even if they had decided

> against trying enzymes at all.

>

> Terminology Used in this Summary

> The information is presented as general groupings because parents

> posted in their own words and no standardized form was used. Bear in mind

> that not all parents posted or commented on all subjects. Throughout this

> summary, the following scale will be used:

> 1. The term " most " is taken to mean greater than 75% of those who

> posted on a particular topic (meaning very, very common).

> 2. The term " many " is taken to mean between 35-70% of those who

posted

> on a particular topic, (meaning common).

> 3. The term " some " is taken to mean between 10-35% of those who

posted

> on a particular topic (meaning not as common but occurring regularly

> enough).

> 4. The term " a few " is taken to mean less than 10%, (meaning rare

but

> occurring a handful of times). This usually means 10 individual people or

> less.

> Hopefully this will convey the general idea of what is taking place

> and is not meant to be an actual quantitative number. Each person is an

> individual and responds differently. Also, the goals for each family are

> different and so what they were hoping to achieve through the use of these

> enzyme products varies.

> 5. For this summary, " a restrictive diet " includes

> gluten-free/casein-free (GFCF), Feingold (removes chemicals, additives,

> dyes, preservatives and possible reactive salicylates), yeast, soy-free,

> corn-free, egg-free, whatever-free, etc, as well as any mixture of diet

> type, although most everyone was on at least the GFCF diet, if on a

> restrictive diet at all.

> 6. The term " enzymes " refer only to the products Peptizyde and Zyme

> Prime from Houston Nutraceuticals.

>

>

> Part 1 - 4-Month Summary of Results of Peptizyde and Zyme Prime

>

> Respondent Profile

> Parents were asked what symptoms they were hoping the enzymes would

> help with. For this poll, parents could select more than one choice.

Dealing

> with digestive problems and overall behavior were listed as primary goals.

> Expanding a restrictive menu followed that.

>

>

> For the full report, go to:

> http://www.angelfire.com/on/FEATNews/pep2.htm

>

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