FW: Gabapentin for RLS (Movement Disorder Congress 2002)

[Guest guest]

Gabapentin for RLS (Movement Disorder Congress 2002)

E-MOVE reports from the Seventh International Congress of Parkinsons

Disease and Movement Disorders, November 10-14 in Miami, Florida. Poster

(P), platform session (PL), and page numbers are from Movement Disorders

2002;17(suppl 5).

1. Effects of gabapentin on restless legs syndrome: Results of a

double-blind crossover study with polysomnography control in 24 patients

D -Borreguero, O Larrosa, K Verger, X Masramon, G

P748; S233-234

Gabapentin is effective for RLS, according to this study.

Twenty-four patients with RLS were randomized to receive either placebo or

gabapentin for 6 weeks, followed by a washout and crossover to the other

arm. The mean dose achieved was 1855 mg/day. Mean IRLSSG rating score was

53% lower for gabapentin-treated patients than for those receiving placebo.

Significant improvements were also seen on several sleep measures. The

authors report that no sign of augmentation was observed.

2. Gabapentin vs. ropinirole in the treatment of restless legs syndrome

S Happe, C Sauter, G Kloesch, B Saletu, J Zeithofer

P102; S45

Gabapentin is as effective as ropinirole in the treatment of RLS, according

to this study.

Sixteen patients were randomized to receive either ropinirole or gabapentin

titrated up until symptoms clearly improved. Treatment lasted 4 weeks, and

final mean doses were 0.78 mg ropinirole and 800 mg gabapentin. Both

treatments significantly improved IRLSSG rating scores, PLMS, and PLMS

index. Gabapentin reduced the arousal index, while ropinirole did not.

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2002 E-MOVE conference reports are made possible in part through

unrestricted educational grants from these sponsors:

Gold Level: Bertek Pharmaceuticals, Elan Pharmaceuticals, Pharmacia

Corporation.

Silver Level: GlaxoKline

Bronze Level: Amarin Corporation, Procter & Gamble Pharmaceuticals,

SchwarzPharma.

========================Copyright 2002 WE MOVE

Editor: (rrobinson@...)

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[Guest guest]

For those who aren't aware, gabepentin is the same as neurontin. Many people

on the list, including my sister, already take this drug. She takes it for

neuropathic pain with pretty good results. Not perfect, but better.

Jean & Chrissie