One more study on Arimidex

[Guest guest]

OK, regarding to my prior posting, here is another study -- I don't

know if it is the " pioneering one " that was referred to or not. I

will keep looking. Jenn

Delayed closure of epiphyseal cartilages induced by the aromatase

inhibitor anastrozole. Would it help short children grow up?

Faglia G, Arosio M, Porretti S.

Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University

of Milan, Italy. giovanni.faglia@...

Estrogens locally generated from androgen precursors due to the

action of aromatase play a main role in epiphyseal cartilage fusion.

Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3

yr) in a boy previously operated on for a hamartoma causing

precocious puberty and presenting with advanced bone maturation and

nearly fused epiphyseal cartilages, slowed cartilage fusion

consenting a higher final stature than expected (164.4 cm vs 158.4

cm). It is suggested that treatment with aromatase inhibitors, alone

or in combination with rh-GH, may also be useful in children with

constitutional short stature in order to delay epiphyseal closure

and improve the final height.