Guest guest Posted May 12, 2010 Report Share Posted May 12, 2010 I was so excited to read those on pub med this morning... I am meeting my GI this afternoon and will print the abstracts for him, as well as informations about LDN and SCD. I'm hoping, naively, that he will be at least a tiny bit interested... I need the courage to face him up with my beliefs !! Does anybody ever been tested for Klebsiella ? ***** A possible link between Crohn's disease and ankylosing spondylitis via Klebsiella infections. Ebringer A, Rashid T, Tiwana H, C. School of Biomedical and Health Sciences, King's College London, 150 Stamford Street, London, SE1 9NN, UK. alan.ebringer@... Abstract Crohn's disease (CD) is an immune-mediated gastrointestinal inflammatory disease, which could arise from an interplay between genetic and environmental factors. Klebsiella microbes were suggested to have a vital role in the initiation and perpetuation of the disease through the mechanism of molecular mimicry. This proposition is based on the results of various studies where significantly elevated levels of antibodies against the whole bacteria or preparations from Klebsiella microbes and antibodies to collagen types I, III, IV, and V were detected in patients with CD and patients with ankylosing spondylitis (AS). Molecular similarities were found between Klebsiella nitrogenase and HLA-B27 genetic markers and between Klebsiella pullulanase and collagen fibers types I, III, and IV. Furthermore, significantly positive correlations and cross-reactivity binding activities were observed between anti-Klebsiella and anticollagen antibodies among patients with CD and AS. Early treatment of CD patients with anti-Klebsiella measures is proposed, which may involve the use of antibiotics and low starch diet together with other traditionally used immunomodulatory, immunosuppressive, or biologic agents. **** The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. Ebringer A, C. Division of Life Sciences, King's College, London. The majority of ankylosing spondylitis (AS) patients not only possess HLA-B27, but during active phases of the disease have elevated levels of total serum IgA, suggesting that a microbe from the bowel flora is acting across the gut mucosa. Biochemical studies have revealed that Klebsiella bacteria, not only possess 2 molecules carrying sequences resembling HLA-B27 but increased quantities of such microbes are found in fecal samples obtained from AS patients and such patients have Crohn's like lesions in the ileo-caecal regions of the gut. Furthermore AS patients from 10 different countries have been found to have elevated levels of specific antibodies against Klebsiella bacteria. It has been suggested that these Klebsiella microbes, found in the bowel flora, might be the trigger factors in this disease and therefore reduction in the size of the bowel flora could be of benefit in the treatment of AS patients. Microbes from the bowel flora depend on dietary starch for their growth and therefore a reduction in starch intake might be beneficial in AS patients. A " low starch diet " involving a reduced intake of " bread, potatoes, cakes and pasta " has been devised and tested in healthy control subjects and AS patients. The " low starch diet " leads to a reduction of total serum IgA in both healthy controls as well as patients, and furthermore to a decrease in inflammation and symptoms in the AS patients. The role of a " low starch diet " in the management of AS requires further evaluation. **** Annie Chalifour Cronh's disease and ankylosing spondilytis SCD june 2009 Mezavant and naproxen *maybe* on her way to take LDN Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 12, 2010 Report Share Posted May 12, 2010 The relationship between diet and gut flora is pretty obvious here. It is like SCD is staring them in the face. Wish they would finally do some studies and just confirm this already instead of sticking their heads in the sand. PJ PJ > > I was so excited to read those on pub med this morning... I am meeting my GI this afternoon and will print the abstracts for him, as well as informations about LDN and SCD. I'm hoping, naively, that he will be at least a tiny bit interested... I need the courage to face him up with my beliefs !! > > > Does anybody ever been tested for Klebsiella ? > > ***** > A possible link between Crohn's disease and ankylosing spondylitis via Klebsiella infections. > > Ebringer A, Rashid T, Tiwana H, C. > School of Biomedical and Health Sciences, King's College London, 150 Stamford Street, London, SE1 9NN, UK. alan.ebringer@... > Abstract > > Crohn's disease (CD) is an immune-mediated gastrointestinal inflammatory disease, which could arise from an interplay between genetic and environmental factors. Klebsiella microbes were suggested to have a vital role in the initiation and perpetuation of the disease through the mechanism of molecular mimicry. This proposition is based on the results of various studies where significantly elevated levels of antibodies against the whole bacteria or preparations from Klebsiella microbes and antibodies to collagen types I, III, IV, and V were detected in patients with CD and patients with ankylosing spondylitis (AS). Molecular similarities were found between Klebsiella nitrogenase and HLA-B27 genetic markers and between Klebsiella pullulanase and collagen fibers types I, III, and IV. Furthermore, significantly positive correlations and cross-reactivity binding activities were observed between anti-Klebsiella and anticollagen antibodies among patients with CD and AS. Early treatment of CD patients with anti-Klebsiella measures is proposed, which may involve the use of antibiotics and low starch diet together with other traditionally used immunomodulatory, immunosuppressive, or biologic agents. > > > **** > The use of a low starch diet in the treatment of patients suffering from > ankylosing spondylitis. > > Ebringer A, C. > Division of Life Sciences, King's College, London. > > The majority of ankylosing spondylitis (AS) patients not only possess HLA-B27, > but during active phases of the disease have elevated levels of total serum IgA, > suggesting that a microbe from the bowel flora is acting across the gut mucosa. > Biochemical studies have revealed that Klebsiella bacteria, not only possess 2 > molecules carrying sequences resembling HLA-B27 but increased quantities of such > microbes are found in fecal samples obtained from AS patients and such patients > have Crohn's like lesions in the ileo-caecal regions of the gut. Furthermore AS > patients from 10 different countries have been found to have elevated levels of > specific antibodies against Klebsiella bacteria. It has been suggested that these > Klebsiella microbes, found in the bowel flora, might be the trigger factors in > this disease and therefore reduction in the size of the bowel flora could be of > benefit in the treatment of AS patients. Microbes from the bowel flora depend on > dietary starch for their growth and therefore a reduction in starch intake might > be beneficial in AS patients. A " low starch diet " involving a reduced intake of > " bread, potatoes, cakes and pasta " has been devised and tested in healthy control > subjects and AS patients. The " low starch diet " leads to a reduction of total > serum IgA in both healthy controls as well as patients, and furthermore to a > decrease in inflammation and symptoms in the AS patients. The role of a " low > starch diet " in the management of AS requires further evaluation. > > **** > > Annie Chalifour > Cronh's disease and ankylosing spondilytis > SCD june 2009 > Mezavant and naproxen > *maybe* on her way to take LDN > Quote Link to comment Share on other sites More sharing options...
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