RE: 2008 Crohn's study @ Rush University in Chicago - Dietary Treatment of Crohn's Disease

[Guest guest]

Web site of the Clinical Trial is:

http://clinicaltrials.gov/ct2/show/NCT00343642

http://www.rush.edu/rumc/page-1144692715094.html

Detailed

Description:

Several epidemiological

studies and therapeutic observations in the complementary and alternative

medicine (CAM) literature suggest that diet is key to development of CD and its

treatment. We took advantage of these CAM recommendations and designed dietary

interventions. Our preliminary open label studies in IBD patients showed that

our interventions are acceptable and well-tolerated and result in improvement,

reducing symptoms and/or the degree of inflammation. We are now seeking to

validate this finding and determine the mechanisms underlying the effects of

dietary manipulation-such as potential effects on colonic bacterial microflora.

In another pilot study using 16s rDNA bacterial fingerprinting, we demonstrated

that the intestinal microflora of patients with CD differ significantly from

healthy individuals. Whether we can normalize/change the microflora of CD

patients with dietary therapies, however, remains to be determined.

Accordingly, we designed a double blind placebo controlled study to test the

hypotheses that: (1) dietary manipulation with either diet or a FOS supplement

is an effective CAM therapy that prevents CD relapse (leads to maintenance of

remission) and (2) such dietary manipulation can normalize the microflora of CD

patients and decrease mucosal oxidative damage.

90 patients are expected to

undergo the trial and have a 2:1 chance of receiving active therapy. The trial

is seeking to enroll patients with inactive CD who have been medically induced

into remission within 3 months of enrollment. Subjects are allowed to be on

5-ASA. Subjects will be followed till relapse occurs or up to 52 weeks.

Subjects are asked to fill out a variety of questionnaires, keep a food and

adverse event diary, and have colonoscopy or flexible sigmoidoscopy for colonic

tissue collection at the beginning and end of the study period.

Significance. This study could

provide information to suggest diet as a safe therapy for IBD and lay the

groundwork for more definitive, randomized, controlled trials.

Ozgur - SCD 3.5 months.

Pls fill in your SCD Testimonial : http://www.homesoft.gen.tr/scd/testimonials.php

From: BTVC-SCD

[mailto:BTVC-SCD ] On Behalf Of self_taught_dr

Sent: Thursday, April 15, 2010 12:31 PM

To: BTVC-SCD

Subject: 2008 Crohn's study @ Rush University in Chicago

I just remembered this link from Fox news about

2 years ago, looking at dietary treatment for Crohn's disease.

http://www.myfoxchicago.com/dpp/news/Possible_Breakthrough_in_Treating_Crohn%C2%92s_Disease

Does anyone on the list go to Rush University? Has anyone heard the results of

the study? I did a little googling, and I think this is the doctor who

conducted the study.

Ece A. Mutlu, MD

Gastroenterology

1725 W. on St., Elevator I

Rush University Medical Center, Professional Building

Ste. 207

Chicago, IL 60612

Phone:

Fax:

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