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World's first fatty tissue stem cell transplant into lung of pulmonary fibrosis

patient carried out in androupolis

A pioneer transplant of stem cells from fatty tissue to the lung of a

65-year-old patient suffering from pulmonary fibrosis, the world's first such

operation, took place at the androupolis University Hospital's Pulmonary

Clinic with a bronchoscopy procedure and only local anaesthesia, and required

just 10 minutes.

The patient, who had been diagnosed with pulmonary fibrosis 2 1/2 years ago,

underwent liposuction three months ago at a private hospital in Athens in order

to isolate stem cells from the fatty tissue removed. Following a required

quality check by the National Research Foundation's Primordial Cells Bank, a

portion of the stem cells was administered to the patient intravenously. Three

months after the first administration, the patient's condition had stabilised,

while a marginal improvement was also recorded, Thrace's Democritus University

pulmonology professor Dr. Demosthenes Bouros told ANA-MPA.

Prof. Bouros added that, in order to achieve better results, the patient was

administered the stem cells a second time on October 8, again via bronchoscopy,

this time directly into the patient's lung.

He explained that the first administration was carried out intravenously

because that was the only known procedure at that time. But the surgeons at the

androupolis University Hospital decided to conduct the second administration

directly into lung, for the first time in the world, in order to achieve better

results.

The patient left for his home in Athens after the second procedure, and the

results of the surgery were expected over the next six months.

Some five million people worldwide are afflicted with pulmonary fibrosis,

the prognosis for which is death within 3-5 years, similar to that for lung

cancer. Patients die either from the disease itself, which causes respiratory

deficiency and failure, or from related complications such as pulmonary

hypertension, bacterial infections and lung cancer.

The cause of the disease, which causes progressive scarring of lung tissue,

is unknown, although risk factors include smoking, gastroesophageal reflux,

various viral infections, and exposure to chemical substances, dust, and heavy

metals.

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