Re: Chol/Sat Fats; & a bit on aromotase inhibitors

[Guest guest]

Although I have to agree with Jody Gough, in that I do think that

many of Beth's postings are a bit too scientific and lack any true

statistical studies using control groups against pediatric groups,

and especially pediatric groups that include either RSS or SGA

children, it is not my role to decide what gets posted or not. I can

also simply skip or delete messages, as Jean correctly stated. The

fact is that I will find studies on RSS/SGA children and post them

here, and would hate for those not to be included.

However, regardless of what information is correct or not, I do

caution parents not to suddenly go out and let your RSS/SGA child

eat tons of saturated fats, when I have yet to see any statistical

pediatric studies using a double-blind study process with control

groups, backing what Beth is saying about the safety of saturated

fats. Do I think science changes its mind about what is safe and

what isn't safe about every day? Absolutely. I keep thinking we're

going to be told that peanut butter causes cancer one of these days,

and we'll all be doomed.

The reason I caution parents is that because there are statistical

and published studies using blind/control groups showing that RSS

and short children born SGA have higher lipid levels than AGA

children. Total cholesterol, LDL and HDL levels are significantly

higher (I believe at the highest significance level). This may be

just one part of the complicated metabolic consequences of an SGA-

born child; we simply don't know yet. Studies have shown that

growth hormone therapy reduces these lipid profile levels, and

brings the lipid profile levels into a normal range (still a bit

higher than AGA but no longer significantly different, and now in

the normal range). And after discontinuation of GH, although the

lipid levels rise a bit, they still stay in the normal range. (For

any of these studies, if you went to the '04 convention, they were

in your handouts; otherwise, email me privately).

I commend all parents for continuing to do a lot of research. I

encourage parents not to make decisions without at least one study

that uses more than 20 subjects and uses a control group, and

ideally is a blind study (not always found). For example, Steve and

I have waited two months after Dr. H wrote the prescription for an

aromotase inhibitor for (Arimidex) for early adrenarche. I

have spent about 8-10 hours reading everything I could get my hands

on. Aromotase inhibitors for the pediatric use of halting the

production of estrogen to control the rapid advancement of a

previously delayed bone age is NOT FDA approved; it is currently

being studied by the FDA. We originally decided NOT to use the

medication. Then I emailed Stanhope, and got my hands on

several new studies that have come out in the last year (with

control groups) -- not all with SGA kids, some were GHD but all were

pediatric. Although there are no promises, we made the decision

last night that we were going to try it for , for at least

one year and see what happens. If anyone else is debating this same

topic, I would be happy to give you the info from the studies and

tell you the list of pros and cons we went through.

Anyway. I just wanted to write. I have NOT gone back and read

other postings because Tyler is sick. So if I missed something

important, will someone let me know.... hee hee. Jenn

> >

> > If you should have any reservations about your child eating

> > saturated fats the following web site should dispel many of

them:

> > http://www.thincs.org/ .

> >

> > THINCS is a steadily growing group of scientists, physicians,

> other

> > academicians and science writers from various countries. Members

> of

> > this group represent different views about the causation of

> > atherosclerosis and cardiovascular disease, some of them are in

> > conflict with others, but this is a normal part of science. What

> > they all oppose is that animal fat and high cholesterol play a

> role.

> > The aim with this website is to inform their colleagues and the

> > public that this idea is not supported by scientific evidence;

in

> > fact, for many years a huge number of scientific studies have

> > directly contradicted it.

> >

> > Since I just found this resource I have not had a chance to

review

> > all the information but I did find a few that I initially pulled

> up

> > to be very informative. You may find these interesting,

> especially

> > the articles from the prestigious British Medical Journal (BMJ)

> and

> > articles contained in the BMJ reference section:

> >

> > http://www.ravnskov.nu/ncep_guidelines.htm

> >

> > http://bmj.bmjjournals.com/cgi/content/full/327/7427/1348-b

> (review

> > references at bottom)

> >

> > http://bmj.bmjjournals.com/cgi/content/full/324/7331/238

(review

> > references at bottom)

> >

> > Beth

[Guest guest]

Hey Jen,

Great posting! ANd thank you so much for your thoughts on Arimidex.

I think Dr.H. is about to consider putting on it, and your

research will really help our decision.

(By the way, for those of you wondering what all the fuss is about

when it comes to adrenarche, Dr. H. had some fascinating perspectives

on why she thinks all RSS children may be extra sensitive to estrogen

(both boys and girls) and that this might be contributing to slower

growth, particularly when early adrenarche sets in, leading to

puberty. She also thinks that giving aromotase inhibitors, which is

less painful than the Lupron shot, is a better way to slow down the

onset of puberty. )

Katy

>

> Although I have to agree with Jody Gough, in that I do think that

> many of Beth's postings are a bit too scientific and lack any true

> statistical studies using control groups against pediatric groups,

> and especially pediatric groups that include either RSS or SGA

> > >

> > > http://bmj.bmjjournals.com/cgi/content/full/324/7331/238

> (review

> > > references at bottom)

> > >

> > > Beth