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Re: Abby's clinic/Zmax

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At a recent Parents CF meeting, our center director said the same thing

about Zithromax. And also mentioned that there have been no studies on

using it in little ones.

So your Doc may be one of the first. I think it is an issue of what dose to

prescribe.

_____

Subject: Abby's clinic/Zmax

Are any of your little ones on azithromycin? Abby is 15 mos. What do y'all

think about this?

Joe

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Zach's only been on Zmax for ear infections. I have heard great

things about taking Zmax three times a week. Maybe this will work

for Abby.

Could you explain the difference between the mucoid and non-mucoid

PA? My clinic didn't mention which one Zach had and I didn't know

to ask.

Sara

> Our clinic visit went fine. We were given a room that had not

been

> used yet that morning. Squeaky wheel.... Abby is 97th percentile

> for wt. and 90th for ht. Got a good throat swab and hopefully

won't

> grow anything. In the event the intermittent Pa is back I talked

to

> Dr. Spencer about Zithromax. From what I've read it's usually

given

> to those with chronic Pa and is very effective in suppressing it.

It

> is not anti-pseudomonal but has some anti-inflammatory properties

> that keep the Pa thrown off balance and make it harder for it to

make

> biofilm. We know that most of the time the Pa will be

intermittant

> and non-mucoid for awhile at first. The study I looked at said

that

> statistically on avg. it turns mucoid within a couple of years.

That

> may have been an old study but never the less it seems to me that

if

> we started her on a Z-max regimen now (if the Pa is back) then

> possibly it could postpone the mucoid Pa from colonizing. Spencer

> acted like he would definitely be interested in trying it and

would

> talk to the team. Of course this all depends on her culture

> results. He said " she would probably be the youngest person in

the

> country on it. " Which surprised me. Are any of your little ones

on

> azithromycin? Abby is 15 mos. What do y'all think about this?

>

> Joe

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Joe,

I don't know if I ever sent you copies of a couple 20-year old research papers.

The studies indicated that

Pa becomes mucoid in the face of magnesium deficiency, and is reversible when Mg

is brought into

balance.

The same thing happens with aminoglycoside antibiotics. Pa becomes resistant to

aminoglycosides

(i.e. Tobramycin, TOBI, gentamicin, amikacin) in the face of Mg deficiency, but

is the resistance is

reversable when Mg deficiency is corrected.

In both instances, this is exactly what happened to my son. He'd cultured mucoid

Pa since 1998, and at the onset

the mucoid Pa was resistant to all aminoglycosides (though his non-mucoid Pa was

sensitive to aminoglycosides).

We began correcting Mg deficiency at the end of January 2002. By April 2002, a

culture showed both mucoid Pa

(and non-mucoid) Pa was sensitive to all aminoglycosides. And at his next

culture in Dec. 2002, the mucoid Pa

didn't even show up.

Some people have shown similar results, though at least in one person, the

aminoglycoside sensitivity reversed to

resistancy. I suspect this is because of other meds he was taking that

continually deplete Mg.

Kim

--- " Joe " <reamsfarm@m...> wrote:

The study I looked at said that

> statistically on avg. it turns mucoid within a couple of years. That

> may have been an old study but never the less it seems to me that if

> we started her on a Z-max regimen now (if the Pa is back) then

> possibly it could postpone the mucoid Pa from colonizing.

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Joe,

Is there a picture of Abby in the Photos section of this site? I

would really like to see her. She about the same age as our " Abby " .

Our Abby is in the 50% for weight and the 75% for height. We have

some big " Abby's " , thank goodness.

I'll be interested in hearing if Zithromax has been given to

toddlers.

Gale

Grandma to Abby (23 months wcf)

> Our clinic visit went fine. We were given a room that had not been

> used yet that morning. Squeaky wheel.... Abby is 97th percentile

> for wt. and 90th for ht. Got a good throat swab and hopefully

won't

> grow anything. In the event the intermittent Pa is back I talked

to

> Dr. Spencer about Zithromax. From what I've read it's usually

given

> to those with chronic Pa and is very effective in suppressing it.

It

> is not anti-pseudomonal but has some anti-inflammatory properties

> that keep the Pa thrown off balance and make it harder for it to

make

> biofilm. We know that most of the time the Pa will be intermittant

> and non-mucoid for awhile at first. The study I looked at said that

> statistically on avg. it turns mucoid within a couple of years.

That

> may have been an old study but never the less it seems to me that

if

> we started her on a Z-max regimen now (if the Pa is back) then

> possibly it could postpone the mucoid Pa from colonizing. Spencer

> acted like he would definitely be interested in trying it and would

> talk to the team. Of course this all depends on her culture

> results. He said " she would probably be the youngest person in the

> country on it. " Which surprised me. Are any of your little ones

on

> azithromycin? Abby is 15 mos. What do y'all think about this?

>

> Joe

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Gale,

I haven't done that yet but as you may suspect I can fix you right

up. Always proud to show off my brood. I'll look into how to get

that done on this site. Meanwhile I'll send you one direct.

Joe

> > Our clinic visit went fine. We were given a room that had not

been

> > used yet that morning. Squeaky wheel.... Abby is 97th

percentile

> > for wt. and 90th for ht. Got a good throat swab and hopefully

> won't

> > grow anything. In the event the intermittent Pa is back I talked

> to

> > Dr. Spencer about Zithromax. From what I've read it's usually

> given

> > to those with chronic Pa and is very effective in suppressing

it.

> It

> > is not anti-pseudomonal but has some anti-inflammatory properties

> > that keep the Pa thrown off balance and make it harder for it to

> make

> > biofilm. We know that most of the time the Pa will be

intermittant

> > and non-mucoid for awhile at first. The study I looked at said

that

> > statistically on avg. it turns mucoid within a couple of years.

> That

> > may have been an old study but never the less it seems to me that

> if

> > we started her on a Z-max regimen now (if the Pa is back) then

> > possibly it could postpone the mucoid Pa from colonizing.

Spencer

> > acted like he would definitely be interested in trying it and

would

> > talk to the team. Of course this all depends on her culture

> > results. He said " she would probably be the youngest person in

the

> > country on it. " Which surprised me. Are any of your little ones

> on

> > azithromycin? Abby is 15 mos. What do y'all think about this?

> >

> > Joe

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