Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.

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Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study

Group.

Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR,

Dimagno EP, Andren-Sandberg A, Domellof L.

Department of Surgery, New York Medical College, Valhalla 10595.

BACKGROUND. The results of case-control studies and anecdotal reports suggest

that pancreatitis may be a risk factor for pancreatic cancer, but there have

been no studies of sufficient size and power to assess the magnitude of the

relation between these two diseases. METHODS AND RESULTS. We undertook a

multicenter historical cohort study of 2015 subjects with chronic pancreatitis

who were recruited from clinical centers in six countries. A total of 56 cancers

were identified among these patients during a mean (+/-SD) follow-up of 7.4 +/-

6.2 years. The expected number of cases of cancer calculated from

country-specific incidence data and adjusted for age and sex was 2.13, yielding

a standardized incidence ratio (the ratio of observed to expected cases) of 26.3

(95 percent confidence interval, 19.9 to 34.2). For subjects with a minimum of

two or five years of follow-up, the respective standardized incidence ratios

were 16.5 (95 percent confidence interval, 11.1 to 23.7) and 14.4 (95 percent

confidence interval, 8.5 to 22.8). The cumulative risk of pancreatic cancer in

subjects who were followed for at least 2 years increased steadily, and 10 and

20 years after the diagnosis of pancreatitis, it was 1.8 percent (95 percent

confidence interval, 1.0 to 2.6 percent) and 4.0 percent (95 percent confidence

interval, 2.0 to 5.9 percent), respectively. CONCLUSIONS. The risk of pancreatic

cancer is significantly elevated in subjects with chronic pancreatitis and

appears to be independent of sex, country, and type of pancreatitis.

Link:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Retrieve & list_uids=8\

479461 & dopt=Abstract

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