Article re: Young Children and Pa

[Guest guest]

-The exact title of the article is " Pseudomonas acquisition in young

patients with Cystic Fibrosis " from the Journal called CURRENT

OPINION IN PULMONARY MEDICINE 9: 492-497, 2003 Author Margaret

Rosenfeld, Bonnie Ramsey and L Gibson

I can't type in the whole thing but the summary says:

Chronic lower airway Pa infection is associated with significant

morbidity and mortality among CF patients. However, first acquisition

of Pa does not appear to cause an immediate and rapid decline in lung

function. Early Pa isolates non-mucoid, antibiotic sensitive and

present at low density suggesting a possible " window of opportunity "

for early intervention.

Anti-pseudomonal therapy for early infection results in transient Pa

eradication, be in-infection with Pa appears inevitable despite early

aggressive treatment. There are no controlled trials demonstrating

clinical benefit in young children. There is a critical need for

further investigation of the clinical outcomes associated with early

intervention, the long term safety profile and the optimal drug

regime.

I couldn't get a copy online but I got a photocopy from the

librarian

at our Children's Hospital. She would do this for anyone staff or

family.

Tina Mertz