lactic acid bacteria supplementation reduces urinary oxalate excretion

[Guest guest]

imo the lactic acid bacteria may partly consume dietary oxalate,

partly displace gut flora that make it, especially fungi, and also

reduced toxic load so the normal body pathways can process oxalates

more effectively

i think biofilm is especially prevalent where you get liquid or

slurry to tissue interfaces like the bladder or kidneys or gall

bladder and obviously the intestine as well

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Use of a probiotic to decrease enteric hyperoxaluria.

Lieske JC, Goldfarb DS, De Simone C, Regnier C.

Division of Nephrology and Hypertension, Mayo Clinic, Mayo

Hyperoxaluria Center, and Mayo Complementary and Integrative Medicine

Program, Rochester, Minnesota 55905, USA. Lieske.@...

BACKGROUND: Patients with inflammatory bowel disease have a 10- to

100-fold increased risk of nephrolithiasis, with enteric

hyperoxaluria being the major risk factor for these and other

patients with fat malabsorptive states. Endogenous components of the

intestinal microflora can potentially limit dietary oxalate

absorption. METHODS: Ten patients were studied with chronic fat

malabsorption, calcium oxalate stones, and hyperoxaluria thought to

be caused by jejunoileal bypass (1) and Roux-en-Y gastric bypass

surgery for obesity (4), dumping syndrome secondary to gastrectomy

(2), celiac sprue (1), chronic pancreatitis (1), and ulcerative

colitis in remission (1). For 3 months, patients received increasing

doses of a lactic acid bacteria mixture (Oxadrop), VSL

Pharmaceuticals), followed by a washout month. Twenty-four-hour urine

collections were performed at baseline and after each month. RESULTS:

Mean urinary oxalate excretion fell by 19% after 1 month (1 dose per

day, P < 0.05), and oxalate excretion remained reduced by 24% during

the second month (2 doses per day, P < 0.05). During the third month

on 3 doses per day oxalate excretion increased slightly, so that the

mean was close to the baseline established off treatment. Urinary

oxalate again fell 20% from baseline during the washout period.

Calcium oxalate supersaturation was reduced while on Oxadrop, largely

due to the decrease in oxalate excretion, although mean changes did

not reach statistical significance. CONCLUSION: Manipulation of

gastrointestinal (GI) flora can influence urinary oxalate excretion

to reduce urinary supersaturation levels. These changes could have a

salutary effect on stone formation rates. Further studies will be

needed to establish the optimal dosing regimen.

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Intracellular bacterial biofilm-like pods in urinary tract

infections.

GG, Palermo JJ, Schilling JD, Roth R, Heuser J, Hultgren

SJ.

Department of Molecular Microbiology, Washington University School

of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

Escherichia coli entry into the bladder is met with potent innate

defenses, including neutrophil influx and epithelial exfoliation.

Bacterial subversion of innate responses involves invasion into

bladder superficial cells. We discovered that the intracellular

bacteria matured into biofilms, creating pod-like bulges on the

bladder surface. Pods contained bacteria encased in a polysaccharide-

rich matrix surrounded by a protective shell of uroplakin. Within

the biofilm, bacterial structures interacted extensively with the

surrounding matrix, and biofilm associated factors had regional

variation in expression. The discovery of intracellular biofilm-like

pods explains how bladder infections can persist in the face of

robust host defenses.