Guest guest Posted October 21, 2003 Report Share Posted October 21, 2003 Journal Watch Emergency Medicine September 24, 2003 Antibiotics Are Not Effective for Sinusitis Posted 10/16/2003 SummaryIn this carefully conducted, randomized, double-blind, placebo-controlled Swiss study, researchers evaluated the efficacy of antibiotics for sinusitis diagnosed clinically in the general-practice setting. Sinus radiographs were performed on all patients, but clinicians were unaware of the results when they made the diagnoses. Inclusion criteria were a history of repeated purulent nasal discharge and sinus pain for at least 48 hours. Initially, purulence on rhinoscopy also was an entry criterion, but it was dropped because few patients had this finding. Of 1565 eligible adult patients, 1313 (84%) were not enrolled: 441 refused consent (including 220 who wanted antibiotics), 439 did not meet entry criteria, and 433 did not participate for other reasons. The remaining 252 patients received either amoxicillin (875 mg) plus clavulanate (125 mg) or placebo twice daily for 6 days and were followed up at 7 and 14 days. Cure was defined as zero days of interference with work or activities of daily life. No difference in the cure rate was detected between the treatment and placebo groups (76.6% and 74.0% at 14 days). The result was the same in the subgroup of patients who had pus on rhinoscopy. Diarrhea was more common in the treatment group (odds ratio at 7 days, 3.89). One placebo recipient developed a brain abscess. Approximately 50% of patients had normal sinus radiographs. CommentAs with most minor illnesses, sinusitis goes away, even in patients with abnormalities detected on imaging. Explaining the natural history of sinusitis to patients has no side effects, does not promote resistance to antibiotics, and gives them what they came for -- attention. -- J. Bohan, MS, MD, FACP, FACEP SourceBucher HC et al. Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis: A placebo-controlled, double-blind, randomized trial in general practice. Arch Intern Med 2003 Aug 11/25; 163:1793-8. Quote Link to comment Share on other sites More sharing options...
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