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Re: Re: OT-LDN again

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immuno suppressant

> Debbie--could you please clarify what you mean by 'this is an immuno instead

of modulator'? What do you mean by immuno?

>

> Thanks,

>

> Terry

>

>

>>

>> They recently posted on the LDN group that one of the doctors (whoever

>> recommends dosing) has declared this an immuno instead of modulator.

>>

>> Since I'm having some symptoms come back--I thought of doing the twice per

>> day or upping the doseage from 1.5mg at night. I started March 11, 2010.

>> Now I'm thinking of stopping completely.

>>

>> Any thoughts?

>>

>> Debbie 41 cd

>>

>

>

>

>

> ------------------------------------

>

>

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This is basically the response received but more info is coming from the doctor involved with the studies, etc.  I really do not understand all of it yet.  All the info is posted at the yahoo group called Any_Other_Dose_LDN.  I joined because I take less than the recommended amount atm.  I may be increasing it soon or trying twice a day.  I'm with Marilyn as far as, I'm still suspicious (even though it works well enough that I know it needs to be increased to be more effective in certain areas but I don't get how it works obviously).

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I think the statement “Low Dose Naltrexone boosts the endorphins to modulate/regulate system” still stands. The effects of LDN is to produce OGF which is the immune suppressor and quickly undoes any immune stimulation from the 4-6 hours of natlrexone blockade acting as an immune system stressor.  The effect of suppressing the immune system is to return it to zero and ready for the next event and eliminate chronic sickness and immune activation – it is my understanding this is called homeostasis.

 So the difference between LDN and the CRAB drugs is that LDN stimulates the system that maintains homeostasis and removes chronic sickness, and CRAB drugs knock out some part of the immune function without regards to the overall system.

 Jayne CrockerChairperson.

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Sorry to go OT Marilyn ;-). 

 

 

immuno suppressant > Debbie--could you please clarify what you mean by 'this is an immuno instead of modulator'? What do you mean by immuno?> > Thanks,

> > Terry> > >> >> They recently posted on the LDN group that one of the doctors (whoever

>> recommends dosing) has declared this an immuno instead of modulator.>> >> Since I'm having some symptoms come back--I thought of doing the twice per>> day or upping the doseage from 1.5mg at night. I started March 11, 2010.

>> Now I'm thinking of stopping completely.>> >> Any thoughts?>> >> Debbie 41 cd>> > > > > > ------------------------------------

> >

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At 05:33 PM 6/15/2010, you wrote:

Sorry to go OT Marilyn ;-).

Well, LDN does tie in with SCD. And since many of us have recommended

LDN, I don't want anyone getting incorrect information on the subject

from this list.

Marilyn

New

Orleans, Louisiana, USA

Undiagnosed IBS since 1976, SCD since 2001

Darn Good SCD Cook

No Human Children

Shadow & Sunny Longhair Dachshund

Babette the Foundling Beagle

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This is where it first came up in online sources, to my knowledge, a few months back:http://painsandiego.com/2010/03/16/dr-ian-zagons-advice-on-ldn-with-other-disease-modifying-drugs-for-multiple-sclerosis/MaraOn Jun 16, 2010, at 7:57 AM, smdsmom2008 wrote:I would be interested in more information.PJSorry to go OT Marilyn ;-).Well, LDN does tie in with SCD. And since many of us have recommended LDN, I don't want anyone getting incorrect information on the subject from this list.— Marilyn New Orleans, Louisiana, USA Undiagnosed IBS since 1976, SCD since 2001 Darn Good SCD Cook No Human Children Shadow & Sunny Longhair Dachshund Babette the Foundling Beagle------------------------------------

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I started in March and had to play around with the dose.  Couldn't taper up to 4.5mg in a month as prescribed for sure.  I had some speech impediment <grin> and a bad eye exam.  I lowered the dose to 1.5mg and took diflucan and it seemed to kick in somehow.  Now it's like I'm finally acclamated to it and I need to up the dose.  I did the twice a day for the first time to see what happens.  If that doesn't work for me, I'll go up to 2.25mg and see how that works.

 

I'm also on four Premarin which is new.  That may be part of the problem but I don't have a choice.

 

I guess it's like anything, you just have to see how it goes.  And I haven't consulted the doc about it yet.  I will in the next visit.  Not sure what she'll say since she was ok with the prescription but she says 'don't play with...' whatever a lot ;-).

 

Debbie 41 cd

 

I don't understand all the technical stuff but I think this is pretty much what it does.  I've been on LDN for 8 months now, and it has definitely, and almost immediately, seriously decreased the number of viruses I used to get. I used to have a cold literally a good part of every week.  LND (or my better working immune system) started knocking them within a few days.  It won't handle a flu or a really bad cold, but it's much much better.  So I think, yes, the LDN is helping my immune system operate more the way it is intended to.

Having an autoimmune condition is like having the immune system running without a " thermostat " , like an air conditioner that is always on no matter what the temperature is. Immune suppressors turn the air conditioner off all the time.

Perhaps what this is trying to say is that LDN turns the air conditioner on for the 4-6 hours it is in your system and then stimulates another chemical to turn the air conditioner off so it can reset itself. This is the concept of homeostasis- a constant " temperature " maintained by an " air conditioner thermostat " that turns on when needed and then turns off when not needed.

We all need our immune systems to work when needed, but they also need to turn off at the right time. Maybe LDN is doing this?

I would be interested in more information.

PJ

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