RTM: Takahashi: fluoride water with more cancer in 23/36 body sites July 2001 rmforall

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RTM: Takahashi:

fluoride water with more cancer in 23/36 body sites July 2001 rmforall

Subject: Cancer July 2001 (PubMed)

Date: Mon, 1 Oct 2001 01:40:07 +0100

http://www.npwa.freeserve.co.uk/ fluoride toxicity

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1512573 & dopt=Abstract

J Epidemiol 2001 Jul;11(4):170-9

Regression analysis of cancer incidence rates and water fluoride

in the U.S.A. based on IACR/IARC (WHO)

data (1978-1992). International Agency for Research on Cancer.

Takahashi K, Akiniwa K, Narita K.

Department of Physical Medicine, Faculty of Medicine

University of Tokyo, Japan.

Age-specific and age-standardized rates (ASR) of

registered cancers for nine communities in the U.S.A.

(21.8 million inhabitants, mainly white) were obtained from IARC data

(1978-82, 1983-87, 1988-92). The percentage

of people supplied with " optimally " fluoridated drinking water (FD)

obtained from the Fluoridation Census 1985,

U.S.A. were used for regression analysis of incidence rates

of cancers at thirty six sites (ICD-WHO, 1957).

About two-thirds of sites of the body (ICD) were

associated positively with FD,

but negative associations were

noted for lip cancer, melanoma of the skin,

and cancers of the prostate and thyroid gland.

In digestive organs the

stomach showed only limited and small intestine no significant link.

However, cancers of the oral cavity and

pharynx, colon and rectum, hepato-biliary and urinary organs

were positively associated with FD.

This was also the case for bone cancers in male,

in line with results of rat experiments.

Brain tumors and T-cell system

Hodgkin's disease, Non-Hodgkin lymphoma, multiple myeloma,

melanoma of the skin and monocytic leukaemia

were also correlated with FD.

Of the 36 sites, 23 were positively significant (63.9%), 9 not

significant (25.0%) and 4 negatively significant (11.1%).

This may indicate a complexity of mechanisms of action of fluoride in

the body, especially in view of the coexisting positive and negative

correlations with the fluoridation index.

The likelihood of fluoride acting

as a genetic cause of cancer requires consideration.

PMID: 11512573

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