Re: @WL adrenarche vs puberty

[Guest guest]

OK - once again I am confused

I think most of us (or maybe just me) preteen/pre everything parents

are all confused. Once adrenarche starts an aromitase inhibitor

should be used? Then depending on bone age then lupron etc should be

used???????????????? - what would happen if you used lupron etc. and

did not use the aromitase inhibitor - - or am I talking about 2

different things here - why would a Dr skip the aromitase inhibitor

and use lupron = does this make sense or am I totally confused...

Thanks

[Guest guest]

Hi ,

I am now intimately involved with the whole adrenarche/puberty issue,

since at last visit, Dr. H. announced that (age 8) is in

adrenarche! can explain things far better than me, but in a

nutshell: RSS children are hyper-sensitive to estrogen! Both boys and

girls.

Adrenarche: estrogen levels start fluctuating, causing breast buds,

pubic hair, body odor, etc.., but puberty has not yet set in. Once

puberty starts, growth spurts in RSS children happen rapidly, even

more rapidly than in other children, then bones fuse, limiting further

growth. To slow adrenarche, arimidex is given. This is a very small,

daily pill. Lupron is a monthly shot, and the needle is large.

Zolodex is also given with implants under skin..jODI can speak to that

treatment.

The advantage of getting adrenarche stopped is that you can postpone

puberty and not have to get to the stage of suppressing it. Lupron

has its own issues in children, such as reduced bone-density in boys.

Dr. Harbison is giving TWO talks on adrenarche and puberty and use of

Arimidex. My husband has decided to fly out to the Convention JUST to

hear those talks. If any of you are on the fence about the Convetion,

please, please consider coming. It will offer you so, so mUch

information!

And, on an ironc note: Both and I will soon have prescriptions

for Arimidex: me, for my breast cancer. , for his adrenarche.

In our household, Estrogen is enemy #1!!!!!

Katy

> OK - once again I am confused

>

> I think most of us (or maybe just me) preteen/pre everything parents

> are all confused. Once adrenarche starts an aromitase inhibitor

> should be used? Then depending on bone age then lupron etc should

be

> used???????????????? - what would happen if you used lupron etc. and

> did not use the aromitase inhibitor - - or am I talking about 2

> different things here - why would a Dr skip the aromitase inhibitor

> and use lupron = does this make sense or am I totally confused...

> Thanks

>

[Guest guest]

Just a few words about Arimidex: As I posted earlier, Max has been

taking this for years. There have been no negative side effects,

thank goodness. Max is still taking it even though he is in

puberty. It is keeping his bone age delayed quite well. At one

point he was advancing and it was delayed by 1 year. Now it has

slowed down and is delayed by 3 years.

I don't understand the science of it, nor can I explain it as well

as and Katy have done. All I know is that Max is growing

at a better rate than he has ever grown and is finally back on the

charts. Whew! We were quite worried as some of you may recall.

We chose to use Zoladex to delay puberty, but have not used it for

about two years now. Once puberty started advancing despite the use

of the medication, Dr. H. decided it was just meant to be and we

ended it. Besides, Max was 15 and it was time to let him look more

his age despite his size, which was not as bad as it had been.

If you want to know more about Zoladex and how it is placed, just

ask. I could probably do it myself these days!

Jodi Z

[Guest guest]

Jodi,

Tim is on Lupron for premature puberty and advanced bone age. He never

took these other meds. Do you know the reasoning about one vs the other?

I'll need to get tapes of the convention on this. He goes to Dr Geffner ,

who teaches another subject at the convention, but seems pretty good...

Inga

At 06:25 PM 7/7/2005 +0000, you wrote:

>Just a few words about Arimidex: As I posted earlier, Max has been

>taking this for years. There have been no negative side effects,

>thank goodness. Max is still taking it even though he is in

>puberty. It is keeping his bone age delayed quite well. At one

>point he was advancing and it was delayed by 1 year. Now it has

>slowed down and is delayed by 3 years.

>

>I don't understand the science of it, nor can I explain it as well

>as and Katy have done. All I know is that Max is growing

>at a better rate than he has ever grown and is finally back on the

>charts. Whew! We were quite worried as some of you may recall.

>

>We chose to use Zoladex to delay puberty, but have not used it for

>about two years now. Once puberty started advancing despite the use

>of the medication, Dr. H. decided it was just meant to be and we

>ended it. Besides, Max was 15 and it was time to let him look more

>his age despite his size, which was not as bad as it had been.

>

>If you want to know more about Zoladex and how it is placed, just

>ask. I could probably do it myself these days!

>

>Jodi Z

>

>

>

>

>

>

[Guest guest]

Thanks to all who have tried to get this very confusing issue thru

this thick head of mine........

I hope that Dr H will be able help us all understand the pros and cons

of " suppress or not to supress " -

Certainly looking forward (i think) to getting this much needed info.

See you all soon